Activation of Macrophages in Response to Biomaterials

Rayahin, Jamie; Gemeinhart, Richard A.

doi:10.1007/978-3-319-54090-0_13

Cited by 34 publications

(34 citation statements)

References 148 publications

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“…Larger implants (>100 µm) induce the foreign body reaction (FBR) and the formation of foreign body giant cell (FBGC), a fusion of multiple macrophages around the implant. FBGCs and fibroblasts deposit a thick, collagen capsule around the implant, which jeopardizes the function of the biomaterial and can necessitate its removal …”

Section: Localized Tam Modulation By Biomaterials: Lessons From Woundmentioning

confidence: 99%

“…Geometry and aspect ratio also affect macrophage activation and phagocytosis. Implants with smoother curvature and longer aspect ratios are viewed as “deactivating” because macrophages are unable to phagocytose them . Implant stiffness also influences macrophage activation: PEG‐RGD hydrogels with reduced stiffness decreased macrophage activation, as evaluated by cytokine secretion and gene profiling, and resulted in a less severe FBR reaction .…”

Section: Localized Tam Modulation By Biomaterials: Lessons From Woundmentioning

confidence: 99%

“…Even implant surface architecture and internal porosity elicits different macrophage responses. Rougher surfaces with deeper grooves increase inflammatory macrophage activation compared to smoother surfaces, and higher porosity increases macrophage infiltration . In addition to the physical characteristics of implants, biochemical modifications can be added to influence macrophages and the FBR.…”

Section: Localized Tam Modulation By Biomaterials: Lessons From Woundmentioning

confidence: 99%

“…Interestingly, hydroxyl modifications induced a significantly lower FBR response. Comprehensive discussions about implant interactions with macrophage are reviewed elsewhere …”

Section: Localized Tam Modulation By Biomaterials: Lessons From Woundmentioning

confidence: 99%

“…FBGCs and fibroblasts deposit a thick, collagen capsule around the implant, which jeopardizes the function of the biomaterial and can necessitate its removal. [110,111] Geometry and aspect ratio also affect macrophage activation and phagocytosis. Implants with smoother curvature and longer aspect ratios are viewed as "deactivating" because macrophages are unable to phagocytose them.…”

Section: Macrophage Response To Engineered Biomaterialsmentioning

confidence: 99%

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Progress on Modulating Tumor‐Associated Macrophages with Biomaterials

2019

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Tumor‐associated macrophages (TAMs) are a complex and heterogeneous population of cells within the tumor microenvironment. In many tumor types, TAMs contribute toward tumor malignancy and are therefore a therapeutic target of interest. Here, three major strategies for regulating TAMs are highlighted, emphasizing the role of biomaterials in these approaches. First, systemic methods for targeting tumor‐associated macrophage are summarized and limitations to both passive and active targeting approaches considered. Second, lessons learned from the significant literature on wound healing and macrophage response to implanted biomaterials are discussed with the vision of applying these principles to localized, biomaterial‐based modulation of tumor‐associated macrophage. Finally, the developing field of engineered macrophages, including genetic engineering and integration with biomaterials or drug delivery systems, is examined. Analysis of major challenges in the field along with exciting opportunities for the future of macrophage‐based therapies in oncology are included.

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Section: Localized Tam Modulation By Biomaterials: Lessons From Woundmentioning

confidence: 99%

Section: Localized Tam Modulation By Biomaterials: Lessons From Woundmentioning

confidence: 99%

Section: Localized Tam Modulation By Biomaterials: Lessons From Woundmentioning

confidence: 99%

“…Interestingly, hydroxyl modifications induced a significantly lower FBR response. Comprehensive discussions about implant interactions with macrophage are reviewed elsewhere …”

Section: Localized Tam Modulation By Biomaterials: Lessons From Woundmentioning

confidence: 99%

Section: Macrophage Response To Engineered Biomaterialsmentioning

confidence: 99%

See 3 more Smart Citations

Progress on Modulating Tumor‐Associated Macrophages with Biomaterials

2019

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A Theoretical Model for Phagocytic Capacity of Phagocytes

Guan

2022

Advcd Theory and Sims

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This work seeks to establish a theoretical model that links phagocytic capacity of phagocytes with geometries of phagocytes and phagocytic objects. The model is applied to four different types of phagocytic objects: a flat surface, a microsphere, a microdisk, and a population of microspheres. For the flat surface, the model assumes that a phagocyte maximizes its contact area between the flat surface and minimizes its non‐contact surface area under a constraint exerted by the volume of the phagocyte's cellular contents. For any of the other three types of objects, the model assumes that a phagocyte completely phagocytoses the object(s) by exhausting its available membrane area. It also assumes that the post‐phagocytosis phagocyte minimizes its surface area. Moreover, the volume of the phagocyte's cellular contents and the geometry of the object impose constraints on the model. For each case, two governing equations are established and combined to derive a single explicit equation with the phagocyte's phagocytic capacity as a function of other parameters. The equations are applied to experimental data for macrophages and neutrophils in the literature. Methods for extending the model and experimentally testing it are discussed.

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Innate but Not Adaptive Immunity Regulates Lung Recovery from Chronic Exposure to Graphene Oxide Nanosheets

et al. 2022

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Graphene has drawn a lot of interest in the material community due to unique physicochemical properties. Owing to a high surface area to volume ratio and free oxygen groups, the oxidized derivative, graphene oxide (GO) has promising potential as a drug delivery system. Here, the lung tolerability of two distinct GO varying in lateral dimensions is investigated, to reveal the most suitable candidate platform for pulmonary drug delivery. Following repeated chronic pulmonary exposure of mice to GO sheet suspensions, the innate and adaptive immune responses are studied. An acute and transient influx of neutrophils and eosinophils in the alveolar space, together with the replacement of alveolar macrophages by interstitial ones and a significant activation toward anti-inflammatory subsets, are found for both GO materials. Micrometric GO give rise to persistent multinucleated macrophages and granulomas. However, neither adaptive immune response nor lung tissue remodeling are induced after exposure to micrometric GO. Concurrently, milder effects and faster tissue recovery, both associated to a faster clearance from the respiratory tract, are found for nanometric GO, suggesting a greater lung tolerability. Taken together, these results highlight the importance of dimensions in the design of biocompatible 2D materials for pulmonary drug delivery system.

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Activation of Macrophages in Response to Biomaterials

Cited by 34 publications

References 148 publications

Progress on Modulating Tumor‐Associated Macrophages with Biomaterials

Progress on Modulating Tumor‐Associated Macrophages with Biomaterials

A Theoretical Model for Phagocytic Capacity of Phagocytes

Innate but Not Adaptive Immunity Regulates Lung Recovery from Chronic Exposure to Graphene Oxide Nanosheets

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