Activation of hydrogen peroxide by copper(II) complexes with some histidine-containing peptides and their SOD-like activities

Ueda, Jun-ichi; Ozawa, Toshihiko; Miyazaki, Makiko; Fujiwara, Y.

doi:10.1016/0162-0134(94)85034-8

Cited by 40 publications

(16 citation statements)

References 18 publications

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“…For instance, [Cu(II) (3,5-diisopropyl salicylate) 2 ] shows important SOD-like activity and can be used for the differentiation of cultured cancer cells from normal cells at concentrations that do not cause cell death [5,6]. Besides, it has been reported that complexes with SOD-mimetic action activate H 2 O 2 to give reactive radical species such as hydroxyl radical (OH AE ) that present high biocidal potency [7,8].…”

Section: Introductionmentioning

confidence: 99%

New copper-based complexes with quinoxaline N1,N4-dioxide derivatives, potential antitumoral agents

Urquiola

Gambino

Cabrera

et al. 2008

Journal of Inorganic Biochemistry

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Section: Introductionmentioning

confidence: 99%

New copper-based complexes with quinoxaline N1,N4-dioxide derivatives, potential antitumoral agents

Urquiola

Gambino

Cabrera

et al. 2008

Journal of Inorganic Biochemistry

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“…In an attempt to design low-molecular weight complexes for mimicking active sites and functions of metalloproteins, paramagnetic copper or manganese complexes with ligands including salicylates, amino acids, porphyrins or Schiff-base derivatives have been prepared [16][17][18][19][20]. These complexes undergo redox reactions similar to superoxide dismutases (SOD) and therefore are efficient catalysts for scavenging superoxide radicals.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Structural Studies of 2-(hydroxyimino)-1-methylpropylideneamino-phenyliminobutan-2-one Oxime, Ligand and its Complexes with Cu(II) and Ni(II)

Karaböcek

Armutcu

2006

Transition Met Chem

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A new ligand incorporating a dioxime moiety, (2E,3E)-3- [(2-{[(1E,2E)-2-(hydroxyimino)-1-methylpropylidene]amino}phenyl)imino]butan-2-one oxime, (H 2 Phmdo) (3) has been prepared by reacting 2,3-butanedionemono-{O-[4-(1-methyl-2-oxo-propylideneaminooxy)-2,3-bis-(1-methyl-2-oxo-propylideneaminooxy-methyl)-but-2-enyl]-oxime} (2) with 1,2-phenylenediamine. Mono-, di-and trinuclear copper(II) and/or nickel(II) complexes of H 2 Phmdo were characterized by elemental analyses, magnetic moments, 1 H-n.m.r. and 13 C-n.m.r., i.r. and mass spectral studies. The mononuclear copper(II) and nickel(II) complexes of H 2 Phmdo were found to have a 1:1 metal:ligand ratio. Elemental analyses, stoichiometric and spectroscopic data of the metal complexes indicated that the metal ions are coordinated to the oxime and imine nitrogen atoms (C=N). In the dinuclear complexes, in which the first Cu (II) or Ni (II) ion was complexed with nitrogen atoms of the oxime and imine groups, the second Cu (II) ion is ligated with dianionic oxygen atoms of the oxime groups and are linked to the 1,10-phenanthroline nitrogen atoms. The data support the proposed structure of H 2 Phmdo and its complexes.

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“…Notably, the copper complex was significantly more potent than that of the co-treating BHT. This prominent observation could be attributed to the biochemical behavior of the copper complexes that was confirmed to be similar to the SOD activities such as Cu(II)(3,5-diisopropylsalicylic acid)2 (CuDIPS) [56], Cu(II) histidine complexes [57], Cu(II) complexes of macrocyclic polyamine derivatives [58], Bis(2,9-dimethyl-1,10-phenaanthroline)-Cu(I)nitrate (Cu(I) (DMP)2) [59] and Cu(II)-oligopeptide [60].…”

Section: Discussionmentioning

confidence: 95%

Protective Effects of Copper (I)-Nicotinate Complex Against Aflatoxicosis

R.¹

2013

TOTOXIJ

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Aflatoxicosis mostly leads to serious clinical signs of malnutrition, growth retardation, and impairment of utilization of nutrients, immunosupression, liver diseases and cancer. Detoxification or prevention of such toxicity is interesting to researchers in change field. In pursuit for an approach, the synthetic copper(I)-nicotinate complex has been evaluated against the traditional Butylated hydroxy toluene (BHT) for possible protective effects as a food additive in induced aflatoxicosed animals. Induction of toxicity in adult rats by AFB 1 60 µg/kg body weight divided on three times a week for consecutive five weeks resulted in marked hepatic necrosis, collagen fibers around portal tract and iron deposits as well as features of general cellular collapse and cirrhosis. The protective effects were tested on two animal groups by associate doses of BHT (0.05 mg / kg B.W.) in one group and copper (I) nicotinate complex (0.4 mg/kg B.W.) in the other. Results showed, in both groups, almost normal histological as well as biochemical markers especially those treated with the copper complex, which suggests that anti-inflammatory copper complex can be used as a protective agent against aflatoxicosis when used in doses resemble those used in pharmaceutical vitamin supplements.

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Activation of hydrogen peroxide by copper(II) complexes with some histidine-containing peptides and their SOD-like activities

Cited by 40 publications

References 18 publications

New copper-based complexes with quinoxaline N1,N4-dioxide derivatives, potential antitumoral agents

New copper-based complexes with quinoxaline N1,N4-dioxide derivatives, potential antitumoral agents

Synthesis and Structural Studies of 2-(hydroxyimino)-1-methylpropylideneamino-phenyliminobutan-2-one Oxime, Ligand and its Complexes with Cu(II) and Ni(II)

Protective Effects of Copper (I)-Nicotinate Complex Against Aflatoxicosis

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