Activation of glutathione peroxidase via Nrf1 mediates genistein’s protection against oxidative endothelial cell injury

Hernandez-Montes, Eva; Pollard, Susan E.; Vauzour, David; Jofre-Montseny, Laia; Rota, Cristina; Rimbach, Gerald; Weinberg, Peter D.; Spencer, Jeremy P.E.

doi:10.1016/j.bbrc.2006.05.197

Cited by 89 publications

(63 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dietary polyphenols may counteract oxidative stress in vascular and inflammatory diseases [7] by modulating key redox sensitive gene transcription via NF-κB and Nrf2/ARE [8] signaling pathways. The balance between antioxidant and pro-oxidant characteristics of polyphenols have been attributed not only to their structural features, but also to the concentration, suggesting induction of antioxidant defence metabolism by low concentrations and ROS production at high concentrations [9].…”

Section: Resultsmentioning

confidence: 99%

Polyphenolic extract association with renin inhibitors in experimental arterial hypertension

Ciocoiu¹,

Bădescu²,

Bădulescu³

et al. 2013

JBiSE

View full text Add to dashboard Cite

Various epidemiological studies have shown an inverse association between the consumption of polyphenols or polyphenol-rich foods and the risk of cardiovascular diseases. The purpose of the study was to emphasize the effects of the association between the renin inhibitor and the polyphenolic extract on biochemical parameters and systolic and diastolic blood pressure. The polyphenols are extracted from isolated and purified vegetable material represented by the mature fruit of the Aronia melanocarpa. The experiment was performed on the arterial hypertension model. In the arterial hypertensive model the cardioprotective effects of the polyphenolic extract from Aronia melanocarpa are represented by the antioxidant, hypocolesterolemiant intervention. Polyphenolic extract from Aronia melanocarpa reduce systolic and diastolic arterial tension values in rats with druginduced hypertension, a phenomenon more pronounced when polyphenols are associated with Aliskiren (renin inhibitor). The combination between the Aliskiren and polyphenolic extract produce superior hypolipidemic and antioxidant effects than in the case of separate administration within experimental arterial hypertension induced in the murine model.

show abstract

Section: Resultsmentioning

confidence: 99%

Polyphenolic extract association with renin inhibitors in experimental arterial hypertension

Ciocoiu¹,

Bădescu²,

Bădulescu³

et al. 2013

JBiSE

View full text Add to dashboard Cite

show abstract

“…It has been demonstrated that genistein inhibits tumor-promoter, 12-O-tetradecanoylphorbol-13-acetate-induced hydrogen peroxide production as well as its function in human polymorphonuclear leukocytes, and HL-60 cells [78;79]. Furthermore, as a follow up to genistein action showing antioxidant capacity, its effect on activation of the transcription factors-Nrf1 and Nrf2, which have been implicated in the regulation of genes involved in response to oxidative stress, was investigated [80], These transcription factors are involved in the regulation of γ-GCS and other detoxification proteins. Genistein was found to induce the cytosolic accumulation and nuclear translocation of Nrf1 and Nrf2 which closely paralleled changes in glutathione peroxidase (GPx) mRNA levels and also the activity of GPx [80].…”

Section: Anti-oxidation Effectsmentioning

confidence: 99%

“…Furthermore, as a follow up to genistein action showing antioxidant capacity, its effect on activation of the transcription factors-Nrf1 and Nrf2, which have been implicated in the regulation of genes involved in response to oxidative stress, was investigated [80], These transcription factors are involved in the regulation of γ-GCS and other detoxification proteins. Genistein was found to induce the cytosolic accumulation and nuclear translocation of Nrf1 and Nrf2 which closely paralleled changes in glutathione peroxidase (GPx) mRNA levels and also the activity of GPx [80]. Genistein has also been shown to stimulate antioxidant protein gene expression in Caco-2 cells [81].…”

Section: Anti-oxidation Effectsmentioning

confidence: 99%

Multi-targeted therapy of cancer by genistein

Banerjee¹,

Li²,

Wang³

et al. 2008

Cancer Letters

552

383

View full text Add to dashboard Cite

Soy isoflavones have been identified as dietary components having an important role in reducing the incidence of breast and prostate cancers in Asian countries. Genistein, the predominant isoflavone found in soy products, has been shown to inhibit the carcinogenesis in animal models. There is a growing body of experimental evidence showing that the inhibition of human cancer cell growth by genisteinis mediated via the modulation of genes that are related to the control of cell cycle and apoptosis. It has been shown that genistein inhibits the activation of NF-κB and Akt signaling pathways, both of which are known to maintain a homeostatic balance between cell survival and apoptosis. Moreover, genistein antagonizes estrogen-and androgen-mediated signaling pathways in the processes of carcinogenesis. Furthermore, genistein has been found to have antioxidant properties, and shown to be a potent inhibitor of angiogenesis and metastasis. Taken together, both in vivo and in vitro studies have clearly shown that genistein, one of the major soy isoflavones, is a promising agent for cancer chemoprevention and further suggest that it could be an adjunct to cancer therapy by virtue of its effects on reversing radioresistance and chemoresistance. In this review, we attempt to provide evidence for these preventive and therapeutic effects of genistein in a succinct manner highlighting comprehensive state-of-the-art knowledge regarding its multi-targeted biological and molecular effects in cancer cells.

show abstract

“…Daidzein, one of the 2 primary isoflavones in soybeans, exhibits anticancer effects (Jing et al, 1993). Recently, genistein was also demonstrates to have anti-inflammatory properties (Hernandez-Montes et al, 2006;Verdrengh et al, 2003), and we found that genistein decreased cisplatin induced apoptosis by regulation p53 induction in kidney, and reactive oxygen species production in cisplatin-treated normal kidney HK-2 cells (Sung et al, 2008). Our previous review described in detail the anti-obesity effects of soybean for type 2 diabetes.…”

Section: Functionality Of Soybean Productsmentioning

confidence: 95%