Activation of free-radical reactions and changes in state of the antioxidative protection system in the blood in experimental influenzal toxicoinfection

Gorbunov, Nikolai V.; Volgarev, A. P.; Brailovskaya, I. V.; Bykova, N. O.; Avrora, N. F.; Киселев, О. И.

doi:10.1007/bf00790055

Cited by 4 publications

(3 citation statements)

References 4 publications

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“…Virulence of the influenza virus is well expressed on the 5th to 6th days after virus instillation (Oda et al 1989;Gorbunov et al 1992;Choi et al 1996). Hence the animals were sacrificed on the 5th day.…”

Section: Animal Infection and Treatmentmentioning

confidence: 99%

Effect of Quercetin on lipid peroxidation and changes in lung morphology in experimental influenza virus infection

Kumar¹,

Sharma²,

Khanna³

et al. 2003

Int J Experimental Path

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Influenza virus infection, induced experimentally in mice, was associated with marked changes in lung morphology viz. epithelial damage with focal areas of reactive papillary hyperplasia, infiltration of leukocytes and development of oxidative stress, as evidenced by increased superoxide radical production and lipid peroxidation (LPO) products by alveolar macrophages. These effects were observed on the 5th day after virus instillation. The levels of superoxide and LPO were measured spectrophotometrically by the nitroblue tetrazolium (NBT) assay and thiobarbituric acid reactive species (TBARS) assay, respectively. The former increased by 1.5-2 fold and the latter was raised by 85% when compared with normal control. Supplementation of intranasal viral instillation with the anti-oxidant, Quercetin, given orally, resulted in a significant decrease in the levels of both superoxide radicals and LPO products. There was also a significant decrease in the number of infiltrating cells. A mild to moderate protective effect was observed in lung morphology. Thus, Quercetin may be useful as a drug in reducing the oxidative stress induced by influenza virus infection in the lung, and protect it from the toxic effects of the free radicals.

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Section: Animal Infection and Treatmentmentioning

confidence: 99%

Effect of Quercetin on lipid peroxidation and changes in lung morphology in experimental influenza virus infection

Kumar¹,

Sharma²,

Khanna³

et al. 2003

Int J Experimental Path

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“…trypanosomosis (Igbokwe et al, 1992), lung diseases, such as emphysema, pneumoconiosis, smoking-related lung diseases (Akinwande and Adebule, 2003); infectious diseases such as tuberculosis (Gutkin et al, 1986), influenza (Gorbanov et al, 1992), chlamidial infections (Azenabor et al, 1994); hyperoxygenation syndromes;…”

Section: Free Radicals and Pathophysiology Of Diseasesmentioning

confidence: 99%

Nitrate-Induced Oxidative Stress and the Effects of Dietary Antioxidant Vitamins C, E And A: Insights from Experimental and Clinical Studies

Yarube¹

2012

Bayero J. Pure App. Sci.

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Various studies on nitrates and nitrites including their widespread applications, mechanisms of action and biological effects due to their ability to induce oxidative stress have been reviewed. The current vigorous research efforts to explore the potential uses of antioxidants in various disease conditions have been critically examined and presented. The review is also focused on Vitamins C, E and A, among other antioxidants, as they can be chiefly obtained in natural form from fruits and vegetables in almost all parts of the world.

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“…Lack of Cp results in the degradation of ferroportin. As an acute phase protein, plasma Cp levels typically rise in inflammatory states [ 17 , 18 , 19 ], but early time points of Cp activity have not been carefully examined.…”

Section: Introductionmentioning

confidence: 99%

Ceruloplasmin and Hypoferremia: Studies in Burn and Non-Burn Trauma Patients

et al. 2015

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Objective: Normal iron handling appears to be disrupted in critically ill patients leading to hypoferremia that may contribute to systemic inflammation. Ceruloplasmin (Cp), an acute phase reactant protein that can convert ferrous iron to its less reactive ferric form facilitating binding to ferritin, has ferroxidase activity that is important to iron handling. Genetic absence of Cp decreases iron export resulting in iron accumulation in many organs. The objective of this study was to characterize iron metabolism and Cp activity in burn and non-burn trauma patients to determine if changes in Cp activity are a potential contributor to the observed hypoferremia. Material and Methods: Under Brooke Army Medical Center Institutional Review Board approved protocols, serum or plasma was collected from burn and non-burn trauma patients on admission to the ICU and at times up to 14 days and measured for indices of iron status, Cp protein and oxidase activity and cytokines. Results: Burn patients showed evidence of anemia and normal or elevated ferritin levels. Plasma Cp oxidase activity in burn and trauma patients were markedly lower than controls on admission and increased to control levels by day 3, particularly in burn patients. Plasma cytokines were elevated throughout the 14 days study along with evidence of an oxidative stress. No significant differences in soluble transferrin receptor were noted among groups on admission, but levels in burn patients were lower than controls for the first 5 days after injury. Conclusion: This study further established the hypoferremia and inflammation associated with burns and trauma. To our knowledge, this is the first study to show an early decrease in Cp oxidase activity in burn and non-burn trauma patients. The results support the hypothesis that transient loss of Cp activity contributes to hypoferremia and inflammation. Further studies are warranted to determine if decreased Cp activity increases the risk of iron-induced injury following therapeutic interventions such as transfusions with blood that has undergone prolonged storage in trauma resuscitation.

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Activation of free-radical reactions and changes in state of the antioxidative protection system in the blood in experimental influenzal toxicoinfection

Cited by 4 publications

References 4 publications

Effect of Quercetin on lipid peroxidation and changes in lung morphology in experimental influenza virus infection

Effect of Quercetin on lipid peroxidation and changes in lung morphology in experimental influenza virus infection

Nitrate-Induced Oxidative Stress and the Effects of Dietary Antioxidant Vitamins C, E And A: Insights from Experimental and Clinical Studies

Ceruloplasmin and Hypoferremia: Studies in Burn and Non-Burn Trauma Patients

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