2023
DOI: 10.21203/rs.3.rs-2534098/v1
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Activation of ET/ETR axis in myocardial tissue characterizes heart failure induced by experimental autoimmune myocarditis

Abstract: Background: Endothelial dysfunction is characterized by an imbalance between endothelium-derived vasodilatory and vasoconstrictive effects and may play an important role in the development of heart failure. More and more studies have shown that endothelial-derived NO-mediated vasodilation is attenuated in heart failure patients. However, the role of ET-1 and its receptors in heart failure remains controversial. The aim of this study is to determine whether ET-1 and its receptor are activated in myocarditis and… Show more

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