Activation of estrogen receptor-β by a special extract of Rheum rhaponticum (ERr 731®), its aglycones and structurally related compounds

Möller, F.; Richter, Tobias; Unger, C.; Weigt, Carmen; Wober, Jannette; Zierau, O; Rettenberger, Reinhard; Kaszkin-Bettag, Marietta; Vollmer, G.

doi:10.1055/s-2006-954928

Cited by 1 publication

(2 citation statements)

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“…The root extract of R. rhaponticum has been used in Germany for decades to reduce climacteric symptoms of peri-and post-menopausal women [24] . ERr 731 ® is a standardized R. rhaponticum root extract that contains rhaponticin as the active ingredient [25] . ERr 731 ® specifically binds to ER-β without activating ER-α, thereby causing a decrease in menopausal symptom Fig.…”

Section: Findings and Interpretationsmentioning

confidence: 99%

“…In a study of perimenopausal women with climacteric symptoms, supplementation of R. rhaponticum root extract for 12 weeks resulted in a significant reduction in the severity of climacteric symptoms and improvement in overall QoL, compared with placebo supplementation, while none of the subjects had any adverse effects or uterine/endometrial-related abnormalities [16] . The post-hoc evaluation of the study was published separately, in which the R. rhaponticum root extract supplementation was found to significantly reduce anxiety and depression in perimenopausal subjects, compared with the placebo group [25] . In a similar study, supplementation of R. rhaponticum root extract was associated with a significant reduction in the MRS score and significantly improved treatment outcomes in perimenopausal women [17] .…”

Section: Comparison With Other Studiesmentioning

confidence: 99%

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Efficacy evaluation of standardized Rheum rhaponticum root extract (ERr 731®) on symptoms of menopause: A systematic review and meta-analysis study

Dubey,

Sureja,

Kheni

2024

J Biomed Res

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Menopause is characterized by various physical, mental and emotional symptoms. ERr 731 ® is a standardized extract from Rheum rhaponticum root and has been clinically studied for its role in reducing menopausal symptoms. The current systematic review and meta-analysis aimed to evaluate the efficacy of ERr 731 ® supplementation in alleviating the severity of menopausal symptoms. In this review, we searched across three online databases up to March 2023, evaluated the quality of the included studies by the Physiotherapy Evidence Database scale, and assessed the risk of bias by the Cochrane Risk of Bias tool. We then performed a meta-analysis using RevMan software to estimate the pooled mean difference (MD). The study protocol was registered in the Prospective Register of Systematic Reviews (CRD42023416808). After screening and evaluation, we included four high-quality studies (a total of 390 participants; the ERr 731 ® group: 193 participants; the control group: 197 participants) in the meta-analysis. The results showed that ERr 731 ® supplementation significantly reduced the Menopause Rating Scale score (MD: –15.12; P < 0.001), compared with control therapy. Sensitivity analysis revealed no effect of individual studies on the overall pooled estimate or overall observed heterogeneity. The current review provides evidence that ERr 731 ® supplementation is effective in reducing menopause symptoms. Potential bias and high heterogeneity in the results warrant further clinical studies.

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Section: Findings and Interpretationsmentioning

confidence: 99%