Activation of estrogen receptor α inhibits TLR4 signaling in macrophages and alleviates the instability of atherosclerotic plaques in the postmenopausal stage

Meng, Qingcai; Bi, Yunhui; Hong, Feng; Ding, Xue; Zhang, Shurui; Chen, Qi; Wang, Liang; Zhang, Qichun; Liu, Yu; Tong, Huangjin; Wu, Lixing; Bian, Huimin

doi:10.1016/j.intimp.2023.109825

Cited by 2 publications

(1 citation statement)

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“…Postmenopausal osteoporosis is a systemic bone disease characterized by low bone mass after menopause. It was reported that activation of estrogen receptor α (ERα) in the postmenopausal stage could inhibit TLR4 signaling and macrophage-related inflammation ( 69 ). Consistently, Guo et al.…”

Section: Clinical Significances Of Tlr4 In Osteoporosismentioning

confidence: 99%

The critical role of toll-like receptor 4 in bone remodeling of osteoporosis: from inflammation recognition to immunity

Zhu,

Du,

Zhang

et al. 2024

Front. Immunol.

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Osteoporosis is a common chronic metabolic bone disorder. Recently, increasing numbers of studies have demonstrated that Toll-like receptor 4 (TLR4, a receptor located on the surface of osteoclasts and osteoblasts) plays a pivotal role in the development of osteoporosis. Herein, we performed a comprehensive review to summarize the findings from the relevant studies within this topic. Clinical data showed that TLR4 polymorphisms and aberrant TLR4 expression have been associated with the clinical significance of osteoporosis. Mechanistically, dysregulation of osteoblasts and osteoclasts induced by abnormal expression of TLR4 is the main molecular mechanism underlying the pathological processes of osteoporosis, which may be associated with the interactions between TLR4 and NF-κB pathway, proinflammatory effects, ncRNAs, and RUNX2. In vivo and in vitro studies demonstrate that many promising substances or agents (i.e., methionine, dioscin, miR-1906 mimic, artesunate, AEG-1 deletion, patchouli alcohol, and Bacteroides vulgatus) have been able to improve bone metabolism (i.e., inhibits bone resorption and promotes bone formation), which may partially attribute to the inhibition of TLR4 expression. The present review highlights the important role of TLR4 in the clinical significance and the pathogenesis of osteoporosis from the aspects of inflammation and immunity. Future therapeutic strategies targeting TLR4 may provide a new insight for osteoporosis treatment.

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Section: Clinical Significances Of Tlr4 In Osteoporosismentioning

confidence: 99%