Activation of ectopic olfactory receptor 544 induces GLP-1 secretion and regulates gut inflammation

Wu, Chunyan; Jeong, Mi Young; Kim, Jung Yeon; Lee, Gil Jae; Kim, Ji Sun; Cheong, Yu Eun; Kang, Hani; Cho, Chung Hwan; Kim, Jimin; Park, Min Kyung; Shin, You Kyoung; Kim, Kyoung Heon; Seol, Geun Hee; Koo, Seung Hoi; Ko, Gwang Pyo; Lee, Sung‐Joon

doi:10.1080/19490976.2021.1987782

Cited by 19 publications

(16 citation statements)

References 72 publications

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“…Studies have shown that bacteroides have antioxidant effects and beneficial effects on the body ( 28 ). Clinical studies have found that the abundance of bacteroides decreases in patients with allergic airway diseases ( 29 , 30 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of microplastics on nasal and intestinal microbiota of the high-exposure population

Wang

Peng

Kang

et al. 2022

Front. Public Health

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BackgroundMicroplastic has become a growing environmental problem. A balanced microbial environment is an important factor in human health. This study is the first observational cross-sectional study focusing on the effects of microplastics on the nasal and gut microbiota in a highly exposed population.MethodsWe recruited 20 subjects from a Plastic Factory (microplastics high-exposure area) and the other 20 from Huanhuaxi Park (microplastics low-exposure area) in Chengdu, China. We performed the microplastic analysis of soil, air, and intestinal secretions by laser infrared imaging, and microbiological analysis of nasal and intestinal secretions by 16S rDNA sequencing.ResultsThe result shows that the detected points of microplastics in the environment of the high-exposure area were significantly more than in the low-exposure area. Polyurethane was the main microplastic component detected. The microplastic content of intestinal secretions in the high-exposure group was significantly higher than in the low-exposure group. Specifically, the contents of polyurethane, silicone resin, ethylene-vinyl acetate copolymer, and polyethylene in the high-exposure group were significantly higher than in the low-exposure group. Moreover, high exposure may increase the abundance of nasal microbiotas, which are positively associated with respiratory tract diseases, such as Klebsiella and Helicobacter, and reduce the abundance of those beneficial ones, such as Bacteroides. Simultaneously, it may increase the abundance of intestinal microbiotas, which are positively associated with digestive tract diseases, such as Bifidobacterium, Streptococcus, and Sphingomonas, and reduce the abundance of intestinal microbiotas, which are beneficial for health, such as Ruminococcus Torquesgroup, Dorea, Fusobacterium, and Coprococcus. A combined analysis revealed that high exposure to microplastics may not only lead to alterations in dominant intestinal and nasal microbiotas but also change the symbiotic relationship between intestinal and nasal microbiotas.ConclusionThe results innovatively revealed how microplastics can affect the intestinal and nasal microecosystems.Clinical trial registrationChiCTR2100049480 on August 2, 2021.

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Section: Discussionmentioning

confidence: 99%

Effect of microplastics on nasal and intestinal microbiota of the high-exposure population

Wang

Peng

Kang

et al. 2022

Front. Public Health

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“…DHM significantly induced intracellular cAMP without changing Ca 2+ and IP 3 . Previous research has demonstrated that cAMP stimulated GLP-1 secretion via the downstream signaling molecule PKA-CREB [ 49 ]. When combined, DHM may reduce the first step of GLP-1 degradation by inhibiting DPP-4 expression in the colon, stimulating GLP-1 secretion by cAMP signaling, thereby increasing the GLP-1 levels in circulation, and the underlying mechanisms warrant further investigation.…”

Section: Discussionmentioning

confidence: 99%

Dihydromyricetin Enhances Exercise-Induced GLP-1 Elevation through Stimulating cAMP and Inhibiting DPP-4

Zhou

et al. 2022

Nutrients

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The purpose of this study was to examine whether endogenous GLP-1 (glucagon-like peptide-1) could respond to exercise training in mice, as well as whether dihydromyricetin (DHM) supplementation could enhance GLP-1 levels in response to exercise training. After 2 weeks of exercise intervention, we found that GLP-1 levels were significantly elevated. A reshaped gut microbiota was identified following exercise, as evidenced by the increased abundance of Bifidobacterium, Lactococcus, and Alistipes genus, which are involved in the production of short-chain fatty acids (SCFAs). Antibiotic treatment negated exercise-induced GLP-1 secretion, which could be reversed with gut microbiota transplantation. Additionally, the combined intervention (DHM and exercise) was modeled in mice. Surprisingly, the combined intervention resulted in higher GLP-1 levels than the exercise intervention alone. In exercised mice supplemented with DHM, the gut microbiota composition changed as well, while the amount of SCFAs was unchanged in the stools. Additionally, DHM treatment induced intracellular cAMP in vitro and down-regulated the gene and protein expression of dipeptidyl peptidase-4 (DPP-4) both in vivo and in vitro. Collectively, the auxo-action of exercise on GLP-1 secretion is associated with the gut-microbiota-SCFAs axis. Moreover, our findings suggest that DHM interacts synergistically with exercise to enhance GLP-1 levels by stimulating cAMP and inhibiting DPP-4.

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“…Under normal physiological conditions, the intestine has a regulatory effect on kidney function, including neuroendocrine involvement. For example, glucagon-like peptide-1 (GLP-1) ( Wu et al., 2021a ; Zhuang et al., 2021 ), guanosine ( Estaki et al., 2014 ), glucagon ( Müller et al., 2020 ; Insuela et al., 2021 ), vasoactive intestinal peptide ( Song et al., 2021 ), polypeptide ( Qi et al., 2021 ), gastrin ( Stewart et al., 2020 ) and other intestinal factors can regulate renal dysfunction. Pathological conditions, due to dietary restrictions and gastrointestinal, most of the patients in the gut microbial metabolism, which is mainly composed of protein hydrolysis into fermentation mode, the end product of protein by the metabolism of gut microbes such as phenol, indole are the endotoxin source of uremia, such as its nephrotoxicity and vascular toxicity has been confirmed that many clinical research institute ( Ondrussek-Sekac et al., 2021 ).…”

Section: Gut-kidney Axismentioning

confidence: 99%

Crosstalk between gut microbiota and renal ischemia/reperfusion injury

Huang

Cao

Chen

et al. 2022

Front. Cell. Infect. Microbiol.

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Renal ischemia-reperfusion injury (IRI) is the main cause of acute kidney injury and the cause of rapid renal dysfunction and high mortality. In recent years, with the gradual deepening of the understanding of the intestinal flora, exploring renal IRI from the perspective of the intestinal flora has become a research hotspot. It is well known that the intestinal flora plays an important role in maintaining human health, and dysbiosis is the change in the composition and function of the intestinal tract, which in turn causes intestinal barrier dysfunction. Studies have shown that there are significant differences in the composition of intestinal flora before and after renal IRI, and this difference is closely related to the occurrence and development of renal IRI and affects prognosis. In addition, toxins produced by dysregulated gut microbes enter the bloodstream, which in turn exacerbates kidney damage. This article reviews the research progress of intestinal flora and renal IRI, in order to provide new treatment ideas and strategies for renal IRI.

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Activation of ectopic olfactory receptor 544 induces GLP-1 secretion and regulates gut inflammation

Cited by 19 publications

References 72 publications

Effect of microplastics on nasal and intestinal microbiota of the high-exposure population

Effect of microplastics on nasal and intestinal microbiota of the high-exposure population

Dihydromyricetin Enhances Exercise-Induced GLP-1 Elevation through Stimulating cAMP and Inhibiting DPP-4

Crosstalk between gut microbiota and renal ischemia/reperfusion injury

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