Activation of DREAM (Downstream Regulatory Element Antagonistic Modulator), a Calcium-Binding Protein, Reduces L-DOPA-Induced Dyskinesias in Mice

Ruiz-DeDiego, Irene; Mellström, Britt; Vallejo, Mario; Naranjo, José R.; Moratalla, Rosario

doi:10.1016/j.biopsych.2014.03.023

Cited by 50 publications

(40 citation statements)

References 70 publications

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“…4F). The activities of both pathways are fundamental in motor control (27), and their imbalances underlie motor deficits in Parkinson's (10,11,28,29) and Huntington's diseases (30). Selective regulation of specific synapses by astrocytes indicates that they may be involved in the RESEARCH | REPORTS plitude changes recorded from D1 and D2 MSNs before and after UV-flash stimulation of D1-or D2-responding astrocytes (n = 9 and 9; *P < 0.05, ***P < 0.001; Student´s t test).…”

mentioning

confidence: 99%

Circuit-specific signaling in astrocyte-neuron networks in basal ganglia pathways

Martín

Bajo‐Grañeras

Moratalla

et al. 2015

Science

261

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Cell type–specific glial networks Glial cells respond to neurotransmitters when nerve cells communicate with each other. Glial cells themselves release gliotransmitters that regulate neural synaptic transmission. Martín et al. studied this reciprocal relationship in a brain region called the dorsal striatum, which has two types of experimentally identifiable neurons and two types of synapses (see the Perspective by Gittis and Brasier). Subpopulations of glial cells selectively responded to the activity of one specific type of neuron. In turn, these specifically activated glial cells signaled only to the same type of neurons but not the other, indicating that glial-nerve signaling is largely cell-type specific. Science , this issue p. 730 ; see also p. 690

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mentioning

confidence: 99%

Circuit-specific signaling in astrocyte-neuron networks in basal ganglia pathways

Martín

Bajo‐Grañeras

Moratalla

et al. 2015

Science

261

250

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“…Among the multiple components, PSD-95 attracts particular attention because of its role mediating the crosstalk between NMDA and D1 receptors, which is determinant for the induction of LID [8]. Fyn has been also singled out as a key component between these two receptors [10], and recently, it has been demonstrated that PSD-95 also modulates the regulatory element DREAM, that has been shown to mediate LID [37].…”

Section: Discussionmentioning

confidence: 99%

The Kinase Fyn As a Novel Intermediate in l-DOPA-Induced Dyskinesia in Parkinson’s Disease

et al. 2017

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“…Immunostaining was carried out in free-floating brain sections (50 μm) with standard avidin-biotin immunohistochemical protocols (Granado et al, 2010; Suarez et al, 2014; Ruiz-DeDiego et al, 2015). The sections were incubated overnight with specific primary antisera (Ab-I), a rabbit TH antiserum (Chemicon International, Temecula, CA) diluted 1:1000; rat monoclonal antibody against DAT (Chemicon International), diluted 1:1000; a rabbit anti glial fibrillary acidic protein antibody (GFAP) (DakoCytomation, Denmark) diluted 1:1000 and rabbit polyclonal anti ionized calcium binding adaptor molecule 1 (Iba1), a microglia/macrophage-specific calcium-binding protein (1:1000), Wako Pure Chemical Industries, Ltd Osaka, Japan) in phosphate buffered saline with Tween solutions containing normal goat serum.…”

Section: Methodsmentioning

confidence: 99%

Fragment C Domain of Tetanus Toxin Mitigates Methamphetamine Neurotoxicity and Its Motor Consequences in Mice

Mendieta

Granado

Aguilera

et al. 2016

IJNPPY

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Background:The C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) is a nontoxic peptide with demonstrated in vitro and in vivo neuroprotective effects against striatal dopaminergic damage induced by 1-methyl-4-phenylpyridinium and 6-hydoxydopamine, suggesting its possible therapeutic potential in Parkinson’s disease. Methamphetamine, a widely abused psychostimulant, has selective dopaminergic neurotoxicity in rodents, monkeys, and humans. This study was undertaken to determine whether Hc-TeTx might also protect against methamphetamine-induced dopaminergic neurotoxicity and the consequent motor impairment.Methods:For this purpose, we treated mice with a toxic regimen of methamphetamine (4mg/kg, 3 consecutive i.p. injections, 3 hours apart) followed by 3 injections of 40 ug/kg of Hc-TeTx into grastrocnemius muscle at 1, 24, and 48 hours post methamphetamine treatment.Results:We found that Hc-TeTx significantly reduced the loss of dopaminergic markers tyrosine hydroxylase and dopamine transporter and the increases in silver staining (a well stablished degeneration marker) induced by methamphetamine in the striatum. Moreover, Hc-TeTx prevented the increase of neuronal nitric oxide synthase but did not affect microglia activation induced by methamphetamine. Stereological neuronal count in the substantia nigra indicated loss of tyrosine hydroxylase-positive neurons after methamphetamine that was partially prevented by Hc-TeTx. Importantly, impairment in motor behaviors post methamphetamine treatment were significantly reduced by Hc-TeTx.Conclusions:Here we demonstrate that Hc-TeTx can provide significant protection against acute methamphetamine-induced neurotoxicity and motor impairment, suggesting its therapeutic potential in methamphetamine abusers.

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Activation of DREAM (Downstream Regulatory Element Antagonistic Modulator), a Calcium-Binding Protein, Reduces L-DOPA-Induced Dyskinesias in Mice

Cited by 50 publications

References 70 publications

Circuit-specific signaling in astrocyte-neuron networks in basal ganglia pathways

Circuit-specific signaling in astrocyte-neuron networks in basal ganglia pathways

The Kinase Fyn As a Novel Intermediate in l-DOPA-Induced Dyskinesia in Parkinson’s Disease

Fragment C Domain of Tetanus Toxin Mitigates Methamphetamine Neurotoxicity and Its Motor Consequences in Mice

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