“…Therefore, upregulation of the AhR appears to be a characteristic of the transformation process. Interestingly, recent studies with prostate carcinoma cells suggest that high AhR levels may be driven by Wnt signaling (Chesire et al, 2004), a pathway implicated in malignant transformation (Miyoshi et al, 2002;Li et al, 2003). Furthermore, nuclear localization of the AhR in Hs578T cells and in other human tumor cell lines (Singh et al, 1996;Ge and Elferink, 1998;Hayashibara et al, 2003) suggests that the AhR may be transcriptionally active, despite the absence of exogenous ligands.…”