Activation of CXCR7 alleviates cardiac insufficiency after myocardial infarction by promoting angiogenesis and reducing apoptosis

Zhang, Sheng; Yue, Jingwen; Ge, Zhuowang; Xie, Yi; Zhang, Min; Jiang, Li

doi:10.1016/j.biopha.2020.110168

Cited by 22 publications

(36 citation statements)

References 48 publications

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“…The treatment effect has been proved in the first aid of severe craniocerebral trauma and chest pain [ 8 ]. In addition, investigations found that triage and first aid for patients with different degrees of critical diseases can maximize the first aid efficiency of nurses at different grades and that the implementation of graded first aid nursing in the rescue process can effectively shorten the rescue time, which has been confirmed in the rescue of patients with abdominal trauma accompanied by hemorrhagic shock [ 9 ]. At present, there are fewer reports about the graded emergency nursing group with the help of multidisciplinary first aid knowledge Internet-based approach in the first aid of AMI, and the following study was carried out on the basis of the background.…”

Section: Introductionmentioning

confidence: 99%

Investigation on the Effect of Graded Emergency Nursing Group under the Assistance of Multidisciplinary First Aid Knowledge Internet-Based Approach on the First Aid of Acute Myocardial Infarction

Song

Han

Rao

et al. 2022

Journal of Healthcare Engineering

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Objective. To analyze the effect of a graded emergency nursing group under the assistance of multidisciplinary first aid knowledge Internet-based approach on the first aid of acute myocardial infarction (AMI). Methods. The clinical data of 90 AMI patients treated in our hospital from March 2019 to March 2020 were selected for the retrospective analysis, and the patients were divided into the observation group and the routine group according to the first aid order, with 45 cases each. The patients in the routine group received the conventional first aid measures, and the graded emergency nursing group mode with the help of multidisciplinary first aid knowledge Internet-based approach was adopted for those in the observation group so as to compare the prognosis, nursing satisfaction scores, etc., between the two groups. Results. Compared with the routine group, patients in the observation group obtained significantly lower various fast reaction indicators and quality of life score ( P < 0.001 ), higher nursing satisfaction score ( P < 0.001 ), lower total complication rate ( P < 0.05 ), higher successful rescue rate ( P < 0.05 ), and lower AMI recurrence rate and PCI reuse rate ( P < 0.05 ). Conclusion. Rescue measures by the graded emergency nursing group with the help of multidisciplinary first aid knowledge Internet-based approach are a reliable method for improving AMI patients, and such strategy greatly promotes patients’ quality of life and reduces the PCI reuse rate. Further research will be conducive to establishing a better solution for AMI patients.

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Section: Introductionmentioning

confidence: 99%

Investigation on the Effect of Graded Emergency Nursing Group under the Assistance of Multidisciplinary First Aid Knowledge Internet-Based Approach on the First Aid of Acute Myocardial Infarction

Song

Han

Rao

et al. 2022

Journal of Healthcare Engineering

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“…Several CXCR7-agonists have also been tested in arterial thrombosis [ 76 ]; in cerebral stroke [ 29 , 30 , 32 , 113 , 114 , 115 ], myocardial infarction/ischemic injury (MI/IR) and heart failure [ 26 , 27 ], diseases that are affected by thrombotic complications ( Figure 4 ); and also in pulmonary [ 104 ] and hepatic fibrosis [ 105 ]. To this effect, various pharmacological CXCR7-agonists have been employed, e.g., cyclic-peptide-(TC14012) [ 104 , 105 , 109 ], allosteric agonist-(AMD3100) [ 27 , 110 ] ACKR3/CXCR7 specific CCX771 [ 103 ], and VUF11207 [ 76 ], demonstrating the therapeutic benefits of ACKR3/CXCR7 in functional recovery following myocardial infarction [ 27 , 28 , 76 ] in impeding pulmonary fibrosis [ 104 ], in promoting hepatic regeneration [ 105 ] and in retarding atheroprogression [ 103 ] ( Table 2 and Figure 4 ). Although most of these investigations did not address the direct impact of pharmacological CXCR7 agonists on platelet response as we have done recently [ 76 ], they certainly verified the regenerative implication of ACKR3/CXCR7 in the target organs or tissues that are infiltrated by activated platelets and that are influenced by platelet response.…”

Section: Therapeutic Implication Of Ackr3/cxcr7 In Platelet-associated Cardiovascular Diseasementioning

confidence: 99%

“…This reduces fibrosis and preserves myocardial function following MI [ 117 , 135 , 136 ]. In recent years, the therapeutic benefits of CXCR7-specific agonist TC14012 [ 27 , 28 ] has also been demonstrated to improve myocardial regeneration and functional recovery following MI [ 137 , 138 ].…”

Section: Therapeutic Implication Of Ackr3/cxcr7 In Platelet-associated Cardiovascular Diseasementioning

confidence: 99%

“…At present, one can only speculate a few possibilities. Expression of ACKR3/CXCR7 is significantly increased at the infarct border zone of myocardium [ 26 , 27 , 28 ], and peri-infarct regions of the brain [ 29 ] in animal models [ 27 , 28 , 30 , 31 ] and humans alike [ 26 , 28 , 32 ]. Firstly, target organ (e.g., myocardium) specific expression of ACKR3/CXCR7 might either override or be complemented by the impact of platelet ACKR3/CXCR7 in the repair and regenerative mechanisms.…”

Section: Introductionmentioning

confidence: 99%

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Atypical Roles of the Chemokine Receptor ACKR3/CXCR7 in Platelet Pathophysiology

Chatterjee

2022

Cells

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The manifold actions of the pro-inflammatory and regenerative chemokine CXCL12/SDF-1α are executed through the canonical GProteinCoupledReceptor CXCR4, and the non-canonical ACKR3/CXCR7. Platelets express CXCR4, ACKR3/CXCR7, and are a vital source of CXCL12/SDF-1α themselves. In recent years, a regulatory impact of the CXCL12-CXCR4-CXCR7 axis on platelet biogenesis, i.e., megakaryopoiesis, thrombotic and thrombo-inflammatory actions have been revealed through experimental and clinical studies. Platelet surface expression of ACKR3/CXCR7 is significantly enhanced following myocardial infarction (MI) in acute coronary syndrome (ACS) patients, and is also associated with improved functional recovery and prognosis. The therapeutic implications of ACKR3/CXCR7 in myocardial regeneration and improved recovery following an ischemic episode, are well documented. Cardiomyocytes, cardiac-fibroblasts, endothelial lining of the blood vessels perfusing the heart, besides infiltrating platelets and monocytes, all express ACKR3/CXCR7. This review recapitulates ligand induced differential trafficking of platelet CXCR4-ACKR3/CXCR7 affecting their surface availability, and in regulating thrombo-inflammatory platelet functions and survival through CXCR4 or ACKR3/CXCR7. It emphasizes the pro-thrombotic influence of CXCL12/SDF-1α exerted through CXCR4, as opposed to the anti-thrombotic impact of ACKR3/CXCR7. Offering an innovative translational perspective, this review also discusses the advantages and challenges of utilizing ACKR3/CXCR7 as a potential anti-thrombotic strategy in platelet-associated cardiovascular disorders, particularly in coronary artery disease (CAD) patients post-MI.

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“…Previous studies have manifested that SDF-1/CXCR7 is involved in the regulation of many diseases, such as acute myocardial infarction (AMI), degenerative disc disease (DDD), steroidinduced osteonecrosis of the femoral head (SONFH) [36,50,51]. Prior to this, many studies have demonstrated that there is a targeting association between SDF-1/CXCR7 and miRNA [52,53] .…”

Section: Microarray Detection Of Idd Np Was Executed To Analyze the Dmentioning

confidence: 99%

The role of miR-31-5p in the development of intervertebral disc degeneration and its therapeutic potential

Zhou

Deng

et al. 2020

Preprint

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Intervertebral disc degeneration (IDD) refers to the abnormal response of cell-mediated progressive structural failure. In order to understand the molecular mechanism of the maintenance and destruction of the intervertebral disc, new IDD treatment methods are developed. Here, we first analyzed the key regulators of IDD through miRNA microarrays. The cell structure and morphology were discovered by Histological and radiographic. Then, the level of miR-31-5p was disclosed by qRT-PCR. The association between miR-31-5p and SDF-1/CXCR7 axis was discovered by 3’-Untranslated region (UTR) cloning and luciferase assay. The apoptosis of cells under different treatments was disclosed by Flow cytometer. The cell proliferation was discovered by EdU assay. Finally, the protein levels of SDF-1, CXCR7, ADAMTS-5, Col II, Aggrecan and MMP13 were discovered by Western blot. The results show that miR-31-5p is a key regulator of IDD and its level is down-regulated in IDD. Overexpression of miR-31-5p facilitates NP cell proliferation, inhibits apoptosis, facilitates ECM formation and inhibits the level of matrix degrading enzymes in NP cells. The SDF-1/CXCR7 axis is the direct target of miR-31-5p. miR-31-5p acts on IDD by regulating SDF-1/CXCR7. In vitro experiments further verified that the up-regulation of miR-31-5p prevented the development of IDD. In conclusion, overexpression of miR-31-5p can inhibit IDD by regulating SDF-1/CXCR7.HighlightsThe level of miR-31-5p decreased in NP;The increase in methylation status is consistent with the decrease in miR-31-5p levels;Upregulation of miR-31-5p stimulated NP cell proliferation, restrained apoptosis, promoted ECM;SDF-1/CXCR7 axis is the target of miR-31-5p;Overexpression of miR-31-5p inhibits IDD through SDF-1/CXCR7;In vitro experiments proved up-regulation of miR-31-5p prevented the development of IDD.

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Activation of CXCR7 alleviates cardiac insufficiency after myocardial infarction by promoting angiogenesis and reducing apoptosis

Cited by 22 publications

References 48 publications

Investigation on the Effect of Graded Emergency Nursing Group under the Assistance of Multidisciplinary First Aid Knowledge Internet-Based Approach on the First Aid of Acute Myocardial Infarction

Investigation on the Effect of Graded Emergency Nursing Group under the Assistance of Multidisciplinary First Aid Knowledge Internet-Based Approach on the First Aid of Acute Myocardial Infarction

Atypical Roles of the Chemokine Receptor ACKR3/CXCR7 in Platelet Pathophysiology

The role of miR-31-5p in the development of intervertebral disc degeneration and its therapeutic potential

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