Activation of coagulation during therapeutic whole body hyperthermia

Strother, S. Vance; Bull, Joan M C; Branham, S.

doi:10.1016/0049-3848(86)90155-6

Cited by 57 publications

(40 citation statements)

References 5 publications

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“…Coagulopathy is recognized in heat stroke occurring among pilgrims in the summer and in whole-body hyperthermia for the treatment of neoplasms [1,2]. We have noted that thrombotic diseases often occur in people after bathing in very hot hot-springs [3].…”

Section: Introductionmentioning

confidence: 99%

Effects of hyperthermal stress on the ultrastructure of platelets with reference to the localization of platelet peroxidase and fibrinogen in vivo

et al. 1997

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Ultrastructure of platelets with the localization of platelet peroxidase and fibrinogen through 3-min 47 degrees C hot-spring bathing was investigated in eight healthy volunteers. The mean sublingual temperature rose about 1.8 degrees C 5 min after the start of bathing. The frequencies of fold, pseudopods, vacuoles, and centralization were increased after bathing. Platelet peroxidase activity was decreased after bathing. Furthermore, fibrinogen was decreased in alpha-granules after bathing. Thus, hyperthermal stress in vivo may activate platelets, resulting in consumption of platelet peroxidase and fibrinogen.

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Section: Introductionmentioning

confidence: 99%

Effects of hyperthermal stress on the ultrastructure of platelets with reference to the localization of platelet peroxidase and fibrinogen in vivo

et al. 1997

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“…Expression of vWF in endothelial cells is higher at low temperature than at normal temperature [52]. The kinetics of vWF proteolysis by the cleaving metalloprotease ADAMTS-13 is temperature-dependent, with slower but complete activity at 4°C and at 22°C.…”

Section: Storage Clearance and Release Underlies The (Reversible) Thmentioning

confidence: 89%

“…[49,50] Bull et al on the other hand recorded no clotting disorders following whole body hyperthermia [51]. Others concluded that whole body hyperthermia was associated with a consumption coagulopathy [52]. Oglesbee et al concluded that the induction of whole body hyperthermia by extracorporeal circulation resulted in a coagulopathy characterized by thrombocytopenia, increased plasma fibrin degradation products, prolonged clotting times, and evidence of spontaneous bleeding [53].…”

Section: Hyperthermia As Independent Feature Influences Hemostatic Fumentioning

confidence: 99%

“…Stacking (Stacked generalization) builds several different models (in contrast to bagging that builds one type of model on different subsamples] [52]. Similar to Boosting, the final decision is made by simple or weighted voting.…”

Section: Predictive Algorithmsmentioning

confidence: 99%

“…Ensemble methods are often used to improve the individual performance of algorithms that constitute ensembles [48] by exploiting the diversity among the models produced. Next a short explanation of the ensemble methods used in this paper is provided: Random Forest [49], Boosting [50], Bootstrap Aggregating (Bagging) [51] and Stacking [52].…”

Section: Predictive Algorithmsmentioning

confidence: 99%

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Platelets, from sample to big data

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'WE CANNOT SOLVE OUR PROBLEMS WITH THE SAME THINKING WE USED WHEN WE CREATED THEM.'Albert Einstein > E X P L O R I N G G R A N U L A R I T Y I N P L AT E L E T R E S E A R C H 4 E X P L O R I N G G R A N U L A R I T Y I N P L AT E L E T R E S E A R C H 5 TABLE OF CONTENTS CHAPTER 1Introduction 7 CHAPTER 2 Hypothermia: effects on platelet function and hemostasis 15CHAPTER 3 Response of platelet concentrates to pressure and temperature 27 changes without impairment of the in vitro function CHAPTER 4 Platelet function during hypothermia in experimental mock circulation 39CHAPTER 5 Early platelet recovery following cardiac surgery with cardiopulmonary 51 bypass CHAPTER 6 Thrombin generation and platelet activation in cytoreductive surgery 67 combined with hyperthermic intra-peritoneal chemotherapy CHAPTER 7 Normalization methods in time series of platelet function assays.91From sample to big data 117 CHAPTER 9 Discussion and valorization 145Nederlandse samenvatting 159 English summary 165Publications 171Biography 177Thanks and acknowledgements 181CHAPTER 8 E X P L O R I N G G R A N U L A R I T Y I N P L AT E L E T R E S E A R C H 6 E X P L O R I N G G R A N U L A R I T Y I N P L AT E L E T R E S E BACKGROUNDFor computationally managing the various levels of detail in biomedical data, biological granularity is indispensable for both dealing effectively with large amounts of data and for structuring the knowledge to analyze and vertically integrate, across the different levels of granularity. Managing granularities of data in the field of platelet research requires specific methodologies to evolve to new knowledge applicable for clinical practice. In this thesis, the author attempted to find inflection points for innovation. Current inflection points in biomedical research are related with the capacity for description and collecting data, the efficiency of compiling, organizing, manipulating these data and extracting true understanding of fundamental biological processes, and insights into human health and disease, from them. PLATELET BIOLOGYPlatelets (2~4 microns in diameter) are essential effectors of cellular hemostasis in humans and other mammals. Although the relevance of platelets in hemostasis and thrombosis is well established, platelets also contribute to host inflammatory and immune responses in infections or injury [1]. Suggested by comparative biology of the innate antibacterial and primitive hemostatic systems of invertebrates, the anucleate human platelet is a specialized cell fragment unique to mammals. Nonmammalian vertebrates, such as fish and birds, have nucleated platelets. Fig. 1.Invertebrates have an even more primitive blood cell, the amebocyte. The amebocyte is the single blood cell of invertebrates with a multitude of functions. The presence of platelets in fetal blood by 12 weeks of gestation suggests that platelet functions are useful to the fetus [2]. Platelets lack nuclei, but perform various vital functions of nucleated cells. Platelets can generate new cell bodies packed with respiring m...

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Alterations in hemostasis associated with hyperthermia in a canine model

et al. 2000

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Use of hyperthermia in the treatment of cancer and viral infection has received renewed interest. However, the in vivo relationship between hyperthermia and direct versus indirect effects upon hemostasis are incompletely defined, although we do know that disseminated intravascular coagulation (DIC) is a common sequel to heat stroke. The purpose of the present study was to more precisely define the relationship between hyperthermia and derangements of hemostasis, thereby providing a guideline for the development of safe hyperthermia treatment regimens. The present investigation examined the in vivo effects of high-grade whole-body hyperthermia (WBH) (42.5 degrees C, 90 min) on hemostasis in a canine model. Induction of hyperthermia via extracorporeal circulation of heated blood (ECC-WBH) caused thrombocytopenia, increased plasma fibrin degradation products (FDPs), prolonged clotting times, increased serum liver enzymes, and evidence of spontaneous bleeding. However, when WBH was induced by peritoneal lavage (PL-WBH), transient thrombocytopenia was the only significant alteration. Temporal correlation between hemostatic alterations and elevations in serum alanine aminotransferase (ALT) levels in the ECC-WBH treatment group suggested that liver injury is responsible, at least in part, for the coagulopathy associated with high-grade hyperthermia and that in the absence of liver injury, identical degrees of hyperthermia cause only incidental decreases in platelet numbers.

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Activation of coagulation during therapeutic whole body hyperthermia

Cited by 57 publications

References 5 publications

Effects of hyperthermal stress on the ultrastructure of platelets with reference to the localization of platelet peroxidase and fibrinogen in vivo

Effects of hyperthermal stress on the ultrastructure of platelets with reference to the localization of platelet peroxidase and fibrinogen in vivo

Platelets, from sample to big data

Alterations in hemostasis associated with hyperthermia in a canine model

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