Activation of C–H bonds of thiosemicarbazones by transition metals: synthesis, structures and importance of cyclometallated compounds

Abstract

Transition metals (PdII, PtII, RuII, RhIIIand IrIII) have induced activation of C–H bonds of thiosemicarbazones and yielded mono-, di-, tri- and tetra-nuclear complexes.

Revisiting the thiosemicarbazonecopper(II) reaction with glutathione. Activity against colorectal carcinoma cell lines

“…Thiosemicarbazones (TSCs) are sulfur-containing organic substances whose biological properties have been extensively studied [1][2][3][4][5][6][7][8], in particular their activities against microbial diseases as malaria, small-pot, influenza, leishmaniasis or chagas [9][10][11][12][13][14], neurological pathologies [15,16] and cancer [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36]. Different biological targets have been identified, like DNA [37][38][39], RNA [40] and several enzymes as RNA-dependent DNA polymerases [41], xanthine oxidoreductase [42], thioredoxin reductase [43,44], topoisomerase IIa [45][46][47] or s...…”

“…cells/well filled with 200 μL of medium) for 24 h under basal conditions and then exposed for other 24 h to different concentrations of the treatments( 2,4,6,8,10,20,25,50 μg per mL of medium of each treatment HPTSC, HPTSC*, 1 and 2) or just DMEM for the not treated cells (NT). Then, MTT reagent dissolved in PBS was added to the wells at a final concentration of 0.5 mg/mL of DMEM and the plate was maintained in the incubator for 2 h. After incubation for 2 h with the MTT solution, the medium was removed and 200 μL DMSO were added to each well.…”

Thiosemicarbazones with tyrosinase inhibitory activity

“…7) and the influence of substitution of proton of thiosemicarbazide terminal group with a phenyl moiety. In this case, IC 50 values were determined for both mono-and diphenolase tyrosinase activities, and they were 1.54 and 2.02 μM for (18) and 1.78 and 0.80 μM for (19). Both compounds revealed a reversible mode of inhibition.…”

“…They have a great variety of pharmacological and biological properties as metal complexes and free ligands. 19,20 This versatile group of compounds has been reported to be used in antimicrobial, 21 antimalarial 22 and anticancer 23,24 treatment.…”

Preparation of novel complexes bearing diphosphine (dppm) derived from thiosemicarbazone palladacycles

“…Their applications are one of the main reasons to study this kind of ligands. Among the different organometallic compounds with thiosemicarbazones, palladium(II) and platinum(II) compounds are of special interest because of their square-planar structure [2][3][4].…”