Activation of blood coagulation in pigs following lower limb gunshot trauma

Münster, Anna-Marie Bloch; Jensen, Jesper K.; Bech, B.; Gram, Jørgen Brodersen

doi:10.1097/00001721-200109000-00008

Cited by 11 publications

(3 citation statements)

References 30 publications

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“…After surgical intervention, activation of coagulation can be observed in humans (Dempfle et al, 1993; Vogel et al, 1996; Dempfle et al, 1997; Galster et al, 2000), in pigs (Munster et al, 2001) and in horses (Prasse et al, 1993) which results in increased fibrin monomer levels up to 14 days (Vogel et al, 1996; Galster et al, 2000). In the current study similar changes were observed in the control horses that underwent Forssell's procedure, in which FM increased to a concentration of 15 mg/l by day 3 post‐operatively.…”

Section: Discussionmentioning

confidence: 99%

Changes in Coagulation and Markers of Fibrinolysis in Horses Undergoing Colic Surgery*

Feige¹,

Kästner²,

Dempfle

et al. 2003

Journal of Veterinary Medicine Series A

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Activation of coagulation can be frequently found in horses with colic. However, it has also been demonstrated as a sequela of surgical trauma alone in humans. The purpose of the present study was to determine changes in coagulation and fibrinolysis in horses that underwent colic surgery and to evaluate whether these changes were secondary to the colic or the surgery and wound healing. Thirty horses that underwent colic surgery with uncomplicated recovery were included. Ten horses with a Forssell's procedure served as control group with a standardized surgical trauma. Besides daily physical examinations during the observation period of 10 days, activated partial thromboplastin time (aPTT), prothrombin time and thrombin time as well as fibrin monomer (FM), D-Dimer (DD) and antithrombin (AT) III were determined. Compared with the control group the aPTT was the only standard coagulation test that was significantly prolonged before and after the event of colic surgery. After surgery, hyperfibrinogenaemia occurred in all groups. In colic groups FM and DD concentrations were within reference range at admission,and were significantly greater than in control horses after surgery. AT III activity decreased after colic surgery, but did not change in the control group. It was concluded that an activated coagulation state after colic surgery has to be expected, resulting not only from the colic disease, but also from the event of surgery.

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Section: Discussionmentioning

confidence: 99%

Changes in Coagulation and Markers of Fibrinolysis in Horses Undergoing Colic Surgery*

Feige¹,

Kästner²,

Dempfle

et al. 2003

Journal of Veterinary Medicine Series A

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“…These results were confirmed using a standardized, quantifiable experimental trauma model. 12 The time course of these parameters shows the immediate activation of the TFdependent coagulation pathway after trauma followed by thrombin activation and fibrin formation, and then secondary fibrinolysis by plasmin. These changes in TF and the other molecular markers observed in trauma patients and animals are not a disease process but a physiological process for hemostasis and wound repair.…”

Section: Tissue Factor In Trauma Patientsmentioning

confidence: 99%

Tissue Factor in Trauma and Organ Dysfunction

Gando

2006

Semin Thromb Hemost

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Tissue factor (TF) performs an essential role in the blood clotting system by activating the extrinsic coagulation pathway following vascular injury. In addition to this physiological hemostatic role for wound repair, TF also plays pivotal roles in organ dysfunction in trauma patients by triggering pathological disseminated thrombosis and inflammation. Constitutively expressed TF in subendothelial cells is released into the circulation following trauma and can be detected as slightly elevated TF levels in the plasma. Liberation of constitutive TF into the blood and inducible tissue factor expression on monocytes and the other cells may synergistically increase plasma TF levels to higher values at the early stage of posttrauma, especially in patients with disseminated intravascular coagulation (DIC) in association with sustained systemic inflammatory response syndrome. Marked TF generation not adequately balanced by physiological coagulation inhibitors such as tissue factor pathway inhibitor in posttrauma DIC patients has been observed. Based on these pieces of evidence, it has now been accepted that combined activation of TF-dependent coagulation inadequately regulated by anticoagulant mechanisms and inflammation may synergistically play important roles in the pathogenesis of posttrauma multiple organ dysfunction syndrome.

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“…The consistent increase in circulating free radicals post-trauma has been asserted to be due to the increasing mobilization of circulating polymorphonuclear (PMN) leucocytes in acute traumatization [8]. Munster et al [9] while studying activation blood coagulation in pigs after lower limb trauma noticed an increase in serum creatinine kinase, body temperature, metabolic and respiratory alkalosis; as well as in moderate leukocytosis. In literature, the near consistent leukocytosis that follows acute trauma is mostly on studies done on white populations and animal models.…”

Section: Introductionmentioning

confidence: 99%

Leucocyte Profile of Adult Nigerians as Indicator of Severity Level of Acute Musculoskeletal Trauma

Asemota

Ekene

Ehebha

et al. 2019

IBRR

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Leucocytosis, marked increase in the number of white blood cells (WBC) is a known physiological response to trauma. In recent times, several studies have asserted the absence of this response in Africans. In view of this, current study investigated the existence of, and prognostic implications of post-traumatic leucocytosis amongst adult Nigerians with acute musculoskeletal (MSK) trauma. Two hundred and twenty three (223) adult male and females (MSK traumatized) and fifty apparently healthy volunteers (adults) were ethically recruited from the National Orthopaedic Hospital, Enugu, regional centre for trauma, orthopaedic, burns and plastic surgery in south-east Nigeria. Using the Leishman’s stained blood smear technique, leucocyte profiles [Neutrophil, Lymphocytes, Basophils, Eosinophils and Monocyte counts] were obtained for each participant. In all case, Age, Gender and duration of hospitalization were also obtained. Following careful analysis, study found, using one way analysis of variance (ANOVA), a statistically significant increase (p < .05) in acutely traumatized subjects; with adults of ages 20 to 49 years constituting the majority (70%). A statistically significant lymphopenia was also observed in test population, with Pearson Product Moment Correlation proving positive for higher levels of WBC counts. A negative correlation was also seen for Neutrophils and lymphocyte counts, implicating the Neutrophil-Lymphocyte Stress Factor (NLSF). We recommend the exploration of the NLSF for prognosis of Leucocytosis in Africans.

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Activation of blood coagulation in pigs following lower limb gunshot trauma

Cited by 11 publications

References 30 publications

Changes in Coagulation and Markers of Fibrinolysis in Horses Undergoing Colic Surgery*

Changes in Coagulation and Markers of Fibrinolysis in Horses Undergoing Colic Surgery*

Tissue Factor in Trauma and Organ Dysfunction

Leucocyte Profile of Adult Nigerians as Indicator of Severity Level of Acute Musculoskeletal Trauma

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