Activation of amygdalar metabotropic glutamate receptors modulates anxiety, and risk assessment behaviors in ovariectomized estradiol-treated female rats

Jesús-Burgos, María De; Torres-Llenza, Vanessa; Pérez-Acevedo, Nivia L.

doi:10.1016/j.pbb.2012.01.016

Cited by 11 publications

(14 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ovariectomy reduces the density of glutamate receptors in some brain structures (Lagunas et al, 2010;de Jesús-Burgos et al, 2012), which reduces GABAergic neurotransmission and possibly contributes to the expression of depressive symptoms. The activation of glutamatergic receptors by agonists was shown to reactivate the GABAergic system in ovariectomized rats, and this activation depended on the concentration of steroid hormones that modulate membrane metabotropic glutamate receptors and participate in the expression of behavioral responses associated with anxiety and depression (de Jesús-Burgos et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…In the long-term these changes are accompanied by the loss of bone density (i.e., osteoporosis), vasomotor alterations, and changes in the sensitivity of γ-aminobutyric acid (GABA), GABAergic and dopaminergic receptors in the brain (Kalu, 1991;Bossé & Di Paolo, 1996). Reductions of glutamate receptor density and cellular proliferation in the hippocampus and other brain structures also occur in ltOVX rats (Lagunas, Calmarza-Font, Diz-Chaves, & García-Segura, 2010;de Jesús-Burgos, Torres-Llenza, & Pérez-Acevedo, 2012). Such changes can negatively affect memory processes (McLaughlin, Bimonte-Nelson, Neisewander, & Conrad, 2008), immune function (Baeza, de Castro, Giménez-Llort, & de la Fuente, 2010), and cardiovascular function (McGregor et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…Ovariectomy has been reported to reduce the density of glutamate receptors and decrease cellular proliferation in the hippocampus and other brain structures (Lagunas et al, 2010;de Jesús-Burgos at al., 2012). Additionally, a reduction of GABA has been observed in the hippocampus (Tominaga et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Actions of progesterone on depression-like behavior in a model of surgical menopause are mediated by GABAA receptors

et al. 2020

View full text Add to dashboard Cite

Introduction. In rats, long-term ovariectomy results in low concentrations of steroid hormones and reproduces anxiety- and depression-like behavior after surgical menopause in women. Progesterone produces antidepressant-like effects two weeks post-ovariectomy (i.e., early post-ovariectomy) through actions on γ-aminobutyric acid-A (GABAA) receptors, but its antidepressant-like effects and mechanism of action in rats eight weeks post-ovariectomy (i.e., late post-ovariectomy, considered a model of surgical menopause) remain unknown. Objective. To explore the antidepressant-like effects of progesterone and the participation of GABAA receptors in rats eight weeks post-ovariectomy. Method. Long-term ovariectomized female Wistar rats were treated sub-acutely with vehicle or progesterone (.5, 1, and 2 mg/kg) and subjected to the open field and forced swim tests, and behavior was compared with cycling or fluoxetine-treated rats. The rats were then pretreated with picrotoxin (1 mg/kg) followed by progesterone (1 mg/kg) to explore the role of GABAA receptors in long-term-induced depression-like behavior. Results. Long-term ovariectomized rats exhibited depression-like behavior in the forced swim test compared with intact rats, an effect that was not observed in progesterone- and fluoxetine-treated long-term ovariectomized rats. These effects were not attributable to psychomotor alterations. In the open field test, the time spent rearing and grooming was lower in ovariectomized rats compared with intact rats, which was not observed in progesterone- and fluoxetine-treated rats. Picrotoxin blocked the effects of progesterone in both behavioral tests. Discussion and conclusion. These results indicated that sub-acute progesterone treatment reduced depression-like behavior through actions on GABAA receptors in a rat model of surgical menopause.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Actions of progesterone on depression-like behavior in a model of surgical menopause are mediated by GABAA receptors

et al. 2020

View full text Add to dashboard Cite

show abstract

“…On the other hand, ovariectomies performed on rats reduce the density of oestrogen receptor α and β in the hippocampus [74]; in addition, reduced activity of glutamate receptors in the basolateral amygdala also occurs [75], and these neurochemical changes are accompanied by an increase in anxiety-like behaviour. While administration of an agonist of the glutamate receptors produces an anxiolytic-like effect in the ovariectomized rats, it is dependent on the availability of oestrogens in the basolateral amygdala [75].…”

Section: Ovariectomized Rats As An Animal Model For Surgical Menopausementioning

confidence: 99%

Anxiety in Natural and Surgical Menopause — Physiologic and Therapeutic Bases

Rodríguez‐Landa¹,

Puga-Olguín²,

JesúsGermán-Ponciano³

et al. 2015

A Fresh Look at Anxiety Disorders

View full text Add to dashboard Cite

Generalized anxiety disorder is one of the most common psychiatric disorders, affecting a high percentage of human beings around the world. This emotional disorder possesses marked gender differences and occurs more often in women than in men, in a proportion of . Accompanying the reproductive cycle of women are significant fluctuations in plasma and brain steroid hormone concentrations, including oestradiol, progesterone, and allopregnanolone, among others. These hormonal changes are related to some illnesses and with the development of anxiety and mood swings occurring in the premenstrual and postpartum period, and particularly during the menopause. Menopause is a clinical term used to indicate the cessation of the woman's reproductive ability that occurs naturally, but also may be surgically induced by bilateral oophorectomy, with or without the removal of the Fallopian tubes and uterus. Natural menopause includes specific periods related to the physiological and hormonal changes produced by ovarian failure, it is usually a natural stage that occurs to women in midlife, during their late s or early s, indicating the end of the reproductive period in the woman. During the menopause transition years, women experience changes in the production of ovarian hormones, which are associated with significant changes in the physiological, emotional, and affective processes. Unfortunately, surgical menopause occurs at an early age, and produces similar physiological and psychiatric disorders, but they are more severe in this instance. In both cases, typical symptoms associated with menopause critically deteriorate the mental health of the women. In this way, the therapeutic management of clinical symptoms of menopause include replacement hormone therapy, the use of anxiolytic and antidepressant drugs, and other natural alternatives based on the use of chemical compounds obtained from plants such as soya. However, a general effective treatment for menopause symptoms does not yet exist. For this reason, experimental studies have proposed ovariectomy in rats as a potential tool to study the effects of a long-term absence of ovarian hormones associated with surgical menopause, which also allowed the study of substances with potential therapeutic application to ameliorate typical symptoms associated with surgical menopause. The aim of this chapter is to review the participation of ovarian hormones in the regulation of emotional and affective disorders in women with natural or surgical menopause particularly their anatomical pathways, neurotransmission systems, and the resulting behavioural patterns. Finally, preclinical and clinical research suggested that longterm absence of ovarian hormones associated with natural or surgical menopause is the principal cause of physiological and psychiatric disorder in the women therefore, oestrogenic compounds seem to play an important role in the maintenance of the brain structures that regulate anxiety, mood, memory, and cognitive functions in menopausal women.

show abstract

“…Group I mGluRs (mGluR1 and mGluR5 subtypes) are coupled to phospholipase C (PLC) by G q11 proteins. Group I mGluRs is expressed in the rat amygdala, a brain structure involved in the anxiolytic effect of different compounds modulating glutamatergic neurotransmission [ 8 , 35 ]. Systemic administration of group I mGluRs antagonists reduce anxiety during the VCT [ 18 , 37 , 39 , 45 , 48 ].…”

Section: Introductionmentioning

confidence: 99%

Amygdalar activation of group I metabotropic glutamate receptors produces anti- and pro-conflict effects depending upon animal sex in a sexually dimorphic conditioned conflict-based anxiety model

Jesus-Burgos

Gonzalez-Garcia

Cruz-Santa

et al. 2016

Behavioural Brain Research

Self Cite

View full text Add to dashboard Cite

Women are more susceptible than men to develop anxiety disorders, however, the mechanisms involved are still unclear. In this study, we investigated the role of group I metabotropic glutamate receptors (mGluRs), a target for anxiety disorders, and whether estradiol may modulate conflict-based anxiety in female rats by using the Vogel Conflict Test (VCT). We used ovariectomized female rats with high (OVX + EB) and low (OVX) estradiol levels and intact male rats to evaluate sex differences. Infusion of (S)-3,5-Dihydroxyphenylglycine (DHPG), a group I mGluR agonist, into the basolateral amygdala, a region involved in anxiety-responses, statistically increased the number of shocks in OVX, but not OVX + EB female rats at 0.1, nor at 1.0 μM. In contrast, DHPG statistically decreased the number of shocks in male rats at 1.0 μM only. DHPG (0.1 μM) increased the number of recoveries in OVX, but not OVX + EB or male rats. Sex differences were detected for the number of shocks, recoveries and punished licks, where female rats displayed more conflict than male rats. Western blot analyses showed that protein expression of mGluR1, but not mGluR5 was higher in OVX + EB > OVX > male rats in the amygdala, whereas no significant differences were detected in the hippocampus, olfactory bulb and/or the periaqueductal gray. Therefore, DHPG produced paradoxical effects that are sex dependent; producing anxiolytic-like effects in female rats, while anxiogenic-like effects in male rats according to the VCT. These results highlight the importance of including female experimental models to underpin the neural circuitry of anxiety according to sex and for the screening of novel anxiolytic compounds.

show abstract

Activation of amygdalar metabotropic glutamate receptors modulates anxiety, and risk assessment behaviors in ovariectomized estradiol-treated female rats

Cited by 11 publications

References 79 publications

Actions of progesterone on depression-like behavior in a model of surgical menopause are mediated by GABAA receptors

Actions of progesterone on depression-like behavior in a model of surgical menopause are mediated by GABAA receptors

Anxiety in Natural and Surgical Menopause — Physiologic and Therapeutic Bases

Amygdalar activation of group I metabotropic glutamate receptors produces anti- and pro-conflict effects depending upon animal sex in a sexually dimorphic conditioned conflict-based anxiety model

Contact Info

Product

Resources

About