Activation of Abl by Helicobacter pylori: A Novel Kinase for CagA and Crucial Mediator of Host Cell Scattering

Tarp regulates earlyChlamydia-induced host cell survival through interactions with the human adaptor protein SHC1

“…Interestingly, phosphorylation of the H. pylori protein CagA and the EPEC effector Tir was also shown to involve ABL (Swimm et al, 2004;Poppe et al, 2007). Furthermore, CagA, ABL, and CRKII have been shown to physically interact (Tammer et al, 2007).…”

Evaluation of Cell- Morphological Changes by Helicobacter pylori CagA and Pragmin in AGS Human Gastric Carcinoma Cells

“…Of note, after inactivation of Src, CagA phosphorylation is sustained by Abl kinase. However, CagA dependent downstream effects in this way have not yet been known (7,8).…”

“…CagA oncoprotein is delivered directly by the bacterium into gastric epithelial cells via type IV secretion system and localized to the inner side of the plasma membrane. Tyrosine phosphorylation of CagA occurs by Src family kinases (SFKs) such as c-Src, Lyn, Fyn, and Yes or c-Abl kinase at the GluPro-Ile-Tyr-Ala (EPIYA) sequence, which is present in variable numbers in its C-terminal region (6)(7)(8). Depending on the geographic region, 4 distinct EPIYA sites have been described including EPIYA-A, -B, -C, and -D, each of which is conserved (9).…”

Linking epithelial polarity and carcinogenesis by multitasking Helicobacter pylori virulence factor CagA

“…CagL-integrin interaction triggers type IV injection of CagA into gastric epithelial cells. Within the host cells, CagA localizes to the inner surface of the plasma membrane, where it undergoes tyrosine phosphorylation by Src family kinases or Abl kinase (Selbach et al, 2002;Stein et al, 2002;Poppe et al, 2007;Tammer et al, 2007). The tyrosine phosphorylation site of CagA is characterized by the Glu-Pro-IleTyr-Ala (EPIYA) motif, which is present in multiple numbers in the carboxy-terminal polymorphic region (EPIYA-repeat region) of the protein (Higashi et al, 2002a, b).…”