Activation of a passive, mesoporous silica nanoparticle layer through attachment of bacterially-derived carbon-quantum-dots for protection and functional enhancement of probiotics

Wei, Hao; Wang, Geng; Yang, Xiao‐Yu; Kuipers, Jeroen; Mei, Henny C. van der; Busscher, Henk J.

doi:10.1016/j.mtbio.2022.100293

Cited by 10 publications

(9 citation statements)

References 35 publications

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“…In another study, Bifidobacterium infantis was encapsulated using carbon-quantum dots (CQDs) derived from Lactobacillus acidophilus or Escherichia coli, along with boron hydroxylmodified silica nanomaterials [33]. This encapsulation approach enhanced B. infantis survival in simulated gastric fluid and antibiotic exposure.…”

Section: Encapsulation Of Bifidobacterium Using Nanomaterialsmentioning

confidence: 99%

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New insights into the role of nanotechnology in Bifidobacterium biomedical applications

Ghaznavi,

Hashemi,

Abolhosseini

et al. 2024

Adv. Nat. Sci: Nanosci. Nanotechnol.

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The human gastrointestinal tract is colonised by a multifaceted and dynamic population of microorganisms consisting of trillions of microbes called the gut microbiota. Through extensive research using animal models and human studies, the significant contributions of gut microbiota to immune and metabolic balance, protection against pathogens, and even neurobehavioural traits have been established. Members of the genus Bifidobacterium are the first bacteria to colonise the intestinal tract in infants, and now it has been proven that they play a positive role in enhancing the host immunity, nutrient absorption, reducing and treating gastrointestinal infections, as well as improving conditions such as diarrhea, constipation, and eczema. Bacterial nanotechnology is a rapidly growing research area with great potential for improvement and the discovery of innovations in new applications of bacteria such as Bifidobacterium. In this review, we provide an up-to-date summary of the relations of nanotechnology with Bifidobacterium in various fields, including bacterial synthesis of nanoparticles, encapsulation of bacteria, bacterial toxicity of nanomaterial, application in the field of cancer targeting, and also the treatment of other diseases such as Alzheimer’s and IBD.

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Section: Encapsulation Of Bifidobacterium Using Nanomaterialsmentioning

confidence: 99%

“…A protective, active encapsulation enhanced the probiotic performance of B infantiles [33] Artificial enzymes of singleatom catalysts (SAzymes) failures [58]. Solid tumours, in particular, present unique challenges due to their limited exposure to therapeutic agents, leading to poor treatment outcomes.…”

Section: Bifidobacterium Infantis Atcc 15697mentioning

confidence: 99%

New insights into the role of nanotechnology in Bifidobacterium biomedical applications

Ghaznavi,

Hashemi,

Abolhosseini

et al. 2024

Adv. Nat. Sci: Nanosci. Nanotechnol.

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“…Surface decoration of bacteria is a simple yet efficient strategy, which not only gives bacteria the additional ability to resist environmental threats but also endows them with exogenous characteristics that are neither inherent nor naturally achievable in a programmed fashion. [ 30 , 31 , 32 , 33 ] Materials such as chitosan and alginate, [ 28 ] mesoporous silica and carbon quantum dots, [ 34 ] liposomes, [ 27 ] silk fibroin, [ 24 ] and tannic acid [ 23 ] have been exploited to decorate the probiotics for protection from physiological GI condition and improving the therapeutic efficacy. However, the inhibition of intestinal inflammation during the probiotics delivery has not received much attention.…”

Section: Introductionmentioning

confidence: 99%

Prodrug Integrated Envelope on Probiotics to Enhance Target Therapy for Ulcerative Colitis

et al. 2022

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Ulcerative colitis (UC), affecting millions of patients worldwide, is associated with disorders of the gut microbiota. Probiotics-based therapy positively regulating the community structure of gut microbiota is regarded as an efficient intervention for UC. However, oral probiotics delivery is restricted by limited bioactivity, short retention time, complex pathological condition, and single therapeutic efficacy. Here, a bioengineered probiotic decorated with a multifunctional prodrug coating is constructed to ameliorate the aforementioned shortcomings. The results of UC mice induced by dextran sulfate sodium demonstrate that the intrinsic features of the fabricated coating integrate gut microbes protection, colon-targeted drug release, prolonged drug retention, and inflammation regulation. In parallel, the probiotics Lactobacillus rhamnosus GG (LGG) could regulate the composition of the gut microbiota and improve epithelial barrier function, thereby synergistically ameliorating UC. These results provide ample shreds of evidence of the therapeutic effect on UC, therefore, demonstrate a great promise as the potential therapeutic strategy for UC treatment.

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“…Generally, the dosage forms, including liquids, capsules, and pills, have been widely used for protecting the vitality of oral probiotics, − while these formulations are still insufficient to exempt gastric attack and maintain the high survival rate of the probiotics in the GIT. Recently, the surface encapsulation of individual probiotics with a functional layer has become a versatile strategy to modulate the probiotic behaviors with enhanced bioavailability and therapeutic effects compared to capsule packaging. ,− The coating could resist the strong acid and digestive enzymes in gastric fluid but degrade at a desired location in the intestinal tract to restore the bioactivities of the encapsulated probiotics. Interestingly, alginate (Alg), a food additive derived from the polysaccharide of brown algae, presents a promising pH-responsive property and high biocompatibility, implying the great potential to be a gastrointestinal microenvironment responsive and protective coating material around the probiotics. , In addition, oral probiotics are usually coadministered with other therapeutic agents for intestinal disease treatment in the clinic.…”

mentioning

confidence: 99%

Gastrointestinal Microenvironment Responsive Nanoencapsulation of Probiotics and Drugs for Synergistic Therapy of Intestinal Diseases

Peng,

Feng,

Yang

et al. 2023

ACS Nano

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The gut microbiota are prominent in preserving intestinal environmental homeostasis and managing human health, and their dysbiosis has been directly related to many kinds of intestinal diseases. Probiotics-based therapy appears as a promising approach for the treatment of gut microbiota dysbiosis, while it always suffers from limited bioavailability and therapeutic effect after oral administration. Herein, we presented a facile and safe strategy to treat colitis by nanoencapsulation of probiotics and an anti-inflammatory agent, 5-aminosalicylic acid (5-ASA), within the gastrointestinal microenvironment responsive alginate polysaccharide. Because of acid resistance, the alginate-based coating protected probiotics from the harsh gastric condition. The coating could be disintegrated to release probiotics and 5-ASA upon arriving in the intestinal tract, where the pH is normally higher than 5. In the dextran sulfate sodium-induced colitis mouse model, probiotics recovered their bioactivities and acted together with anti-inflammatory 5-ASA to alleviate colitis by upregulating microbiota richness and diversity, reducing expression of proinflammatory cytokines, and restoring intestinal barriers. This work demonstrated the synergistic therapy of intestinal diseases based on alginate-encapsulated probiotics and a clinical drug, which provided an extensive method to improve the therapeutic effect of oral microecologics.

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Activation of a passive, mesoporous silica nanoparticle layer through attachment of bacterially-derived carbon-quantum-dots for protection and functional enhancement of probiotics

Cited by 10 publications

References 35 publications

New insights into the role of nanotechnology in Bifidobacterium biomedical applications

New insights into the role of nanotechnology in Bifidobacterium biomedical applications

Prodrug Integrated Envelope on Probiotics to Enhance Target Therapy for Ulcerative Colitis

Gastrointestinal Microenvironment Responsive Nanoencapsulation of Probiotics and Drugs for Synergistic Therapy of Intestinal Diseases

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