Activation imaging of drugs with hybrid Compton camera: A proof-of-concept study

Koshikawa, N.; Omata, Akihisa; Masubuchi, Miho; Okazaki, Yu; Kataoka, J.; Matsunaga, Keiko; Kato, Hirohisa; Toyoshima, Atsushi; Wakabayashi, Y.; Kobayashi, Tomohiro

doi:10.1063/5.0116570

Cited by 3 publications

(2 citation statements)

References 34 publications

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“…The gold wire ( 197 Au) absorbed thermal neutrons produced from epithermal-neutrons of BNCT system and it becomes 198 Au through the nuclear reaction of 197 Au (n,𝛾) 198 Au. Since 198 Au emits mainly 412-keV gamma rays with 96% probability with relatively long decay time of 2.7 days [8], the gamma photons could be measured to estimate the thermal neutron flux for BNCT systems. The activation of 197 Au is also started to be used for "activation imaging" of such as drags [8,9].…”

Section: Set-up For Imaging Gold Wire With a Gamma Cameramentioning

confidence: 99%

“…Since 198 Au emits mainly 412-keV gamma rays with 96% probability with relatively long decay time of 2.7 days [8], the gamma photons could be measured to estimate the thermal neutron flux for BNCT systems. The activation of 197 Au is also started to be used for "activation imaging" of such as drags [8,9].…”

Section: Set-up For Imaging Gold Wire With a Gamma Cameramentioning

confidence: 99%

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Imaging of gamma photons from activated gold wire using a high-energy gamma camera after irradiation of neutrons from boron neutron capture therapy (BNCT) system

Yamamoto

Kataoka

et al. 2023

J. Inst.

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Gold wire is commonly used for quality assurance (QA) of the neutron beam in a boron neutron capture therapy (BNCT) system. It is set in water and irradiated with the neutron beam, and then 412-keV gamma photons from the activated gold wire are measured by a semiconductor detector. Since this procedure takes time and labor, a more efficient method is desired. To reduce the time and labor to measure the radioactivity of an activated gold wire, we carried out imaging of 412-keV gamma photons from the activated gold wire using a developed high-energy gamma camera. After the gold wire was set in the depth direction in a water-filled phantom and irradiated with neutron beams using the BNCT system, gamma photon imaging was conducted with the developed high-energy gamma camera. On the measured image, a depth profile was set to obtain the neutron distribution, and this was compared with the profile sequentially measured with a semiconductor detector. An image of the 412-keV gamma photons was obtained with an imaging time of 1.5 hours. The estimated depth profile of the neutron beam from the gamma camera image closely matched that measured with a semiconductor detector. Imaging of the gamma photons emitted from the activated gold wire was possible, and it offers an efficient method to measure the thermal neutron distribution of the BNCT system. This method has the potential to reduce the time and labor for QA of a BNCT system.

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Section: Set-up For Imaging Gold Wire With a Gamma Cameramentioning

confidence: 99%

Section: Set-up For Imaging Gold Wire With a Gamma Cameramentioning

confidence: 99%

Imaging of gamma photons from activated gold wire using a high-energy gamma camera after irradiation of neutrons from boron neutron capture therapy (BNCT) system

Yamamoto

Kataoka

et al. 2023

J. Inst.

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INSPIRE: Challenge of 50 kg-class satellite to open up MeV gamma-ray astronomy

Kataoka,

Iwashita,

Tanaka

et al. 2024

Nuclear Instruments and Methods in Physics Research Section A:

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ComptonNet: A direct reconstruction model for Compton camera

Sato,

Tanaka,

Kataoka

2024

Applied Physics Letters

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A Compton camera is a gamma-ray imaging device, especially in the sub-mega-electron volt to higher than mega-electron volt range. Compton cameras have recently attracted attention as an environmental survey tool. However, owing to their limited sensitivity, Compton camera images often suffer from various artifacts, especially when the event statistics are low. To address this challenge, several deep learning models have been proposed to enhance the quality of reconstructed images with limited statistics. However, during the event selection phase of a typical Compton camera image reconstruction, a significant number of events that potentially reflect the source distribution are generally discarded. Effective utilization of these discarded events has the potential to estimate an accurate source distribution from limited statistical data. Thus, we initially developed ComptonNet-v1, a framework designed to directly estimate source distribution by integrating all measured events into a single model. To explicitly implement the difference in contribution between events that interact solely with scatterers, solely with absorbers, or with both, we developed ComptonNet-v2, which integrates these events individually. Consequently, our proposed models exhibited superior performance in both quantitative and qualitative assessments compared with existing models, even under low event statistics. In the future, we plan to implement a more memory-efficient model to estimate the distribution of complex source shapes.

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Activation imaging of drugs with hybrid Compton camera: A proof-of-concept study

Cited by 3 publications

References 34 publications

Imaging of gamma photons from activated gold wire using a high-energy gamma camera after irradiation of neutrons from boron neutron capture therapy (BNCT) system

Imaging of gamma photons from activated gold wire using a high-energy gamma camera after irradiation of neutrons from boron neutron capture therapy (BNCT) system

INSPIRE: Challenge of 50 kg-class satellite to open up MeV gamma-ray astronomy

ComptonNet: A direct reconstruction model for Compton camera

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