Activation imaging: New concept of visualizing drug distribution with wide-band X-ray and gamma-ray imager

Koshikawa, N.; Omata, Akihisa; Masubuchi, Miho; Kataoka, J.; Kadonaga, Yuichiro; Tokoi, K.; Nakagawa, S.; Imada, A.; Toyoshima, Atsushi; Matsunaga, Keiko; Kato, Hirohisa; Wakabayashi, Y.; Kobayashi, Tomohiro; Takamiya, K.; Ueda, Masashi

doi:10.1016/j.nima.2022.167599

Cited by 3 publications

(4 citation statements)

References 12 publications

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“…Since 198 Au emits mainly 412-keV gamma rays with 96% probability with relatively long decay time of 2.7 days [8], the gamma photons could be measured to estimate the thermal neutron flux for BNCT systems. The activation of 197 Au is also started to be used for "activation imaging" of such as drags [8,9].…”

Section: Set-up For Imaging Gold Wire With a Gamma Cameramentioning

confidence: 99%

Imaging of gamma photons from activated gold wire using a high-energy gamma camera after irradiation of neutrons from boron neutron capture therapy (BNCT) system

Yamamoto

Kataoka

et al. 2023

J. Inst.

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Gold wire is commonly used for quality assurance (QA) of the neutron beam in a boron neutron capture therapy (BNCT) system. It is set in water and irradiated with the neutron beam, and then 412-keV gamma photons from the activated gold wire are measured by a semiconductor detector. Since this procedure takes time and labor, a more efficient method is desired. To reduce the time and labor to measure the radioactivity of an activated gold wire, we carried out imaging of 412-keV gamma photons from the activated gold wire using a developed high-energy gamma camera. After the gold wire was set in the depth direction in a water-filled phantom and irradiated with neutron beams using the BNCT system, gamma photon imaging was conducted with the developed high-energy gamma camera. On the measured image, a depth profile was set to obtain the neutron distribution, and this was compared with the profile sequentially measured with a semiconductor detector. An image of the 412-keV gamma photons was obtained with an imaging time of 1.5 hours. The estimated depth profile of the neutron beam from the gamma camera image closely matched that measured with a semiconductor detector. Imaging of the gamma photons emitted from the activated gold wire was possible, and it offers an efficient method to measure the thermal neutron distribution of the BNCT system. This method has the potential to reduce the time and labor for QA of a BNCT system.

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Section: Set-up For Imaging Gold Wire With a Gamma Cameramentioning

confidence: 99%

Imaging of gamma photons from activated gold wire using a high-energy gamma camera after irradiation of neutrons from boron neutron capture therapy (BNCT) system

Yamamoto

Kataoka

et al. 2023

J. Inst.

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“…where E 1,i , E 2,i , σ E1,i , and σ E2,i are the deposited energy and Gaussian standard deviation [24] of the first two interactions, respectively. In Equation (7), if the scattered gamma photon from the first interaction is fully absorbed at the second interaction, a Gaussian function is used to describe the situation (E 0 ∈…”

Section: Wide-energy-range Gamma-ray Imagingmentioning

confidence: 99%

“…The Compton camera [1], which reconstructs images to visually display the spatial distribution of radioactive materials, has found extensive applications in astronomical observation [2], nuclear medicine [3], proton therapy [4,5], neutron activation imaging [6,7], and environmental measurement [8,9]. These applications benefit from the Compton camera's advantages of a wider field of view (2π or 4π) and a wider energy range (from several hundreds of keV to a few MeV).…”

Section: Introductionmentioning

confidence: 99%

“…Ce-doped gadolinium-aluminum-galliumgarnet (Gd 3 Al 2 Ga 3 O 12 :Ce, GAGG:Ce) is selected as the scintillator material due to its characteristics of a high light yield and good energy resolution, being non-hygroscopic, and having no natural radioactivity [19]. The position-sensitive detector of a GAGG:Ce array coupled to a SiPM array has been widely applied in Compton imaging systems and has achieved good imaging results [3,4,[7][8][9]20,21]. In our previous work, two types of GAGG-SiPM detector modules with varying thicknesses were designed to achieve three-Compton imaging in the energy range of 0.3~7 MeV [22].…”

Section: Introductionmentioning

confidence: 99%

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A Portable Three-Layer Compton Camera for Wide-Energy-Range Gamma-ray Imaging: Design, Simulation and Preliminary Testing

Zhang,

Xiao,

Chen

et al. 2023

Sensors

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(1) Background: The imaging energy range of a typical Compton camera is limited due to the fact that scattered gamma photons are seldom fully absorbed when the incident energies are above 3 MeV. Further improving the upper energy limit of gamma-ray imaging has important application significance in the active interrogation of special nuclear materials and chemical warfare agents, as well as range verification of proton therapy. (2) Methods: To realize gamma-ray imaging in a wide energy range of 0.3~7 MeV, a principle prototype, named a portable three-layer Compton camera, is developed using the scintillation detector that consists of an silicon photomultiplier array coupled with a Gd3Al2Ga3O12:Ce pixelated scintillator array. Implemented in a list-mode maximum likelihood expectation maximization algorithm, a far-field energy-domain imaging method based on the two interaction events is applied to estimate the initial energy and spatial distribution of gamma-ray sources. The simulation model of the detectors is established based on the Monte Carlo simulation toolkit Geant4. The reconstructed images of a 133Ba, a 137Cs and a 60Co point-like sources have been successfully obtained with our prototype in laboratory tests and compared with simulation studies. (3) Results: The proportion of effective imaging events accounts for about 2%, which allows our prototype to realize the reconstruction of the distribution of a 0.05 μSv/h 137Cs source in 10 s. The angular resolution for resolving two 137Cs point-like sources is 15°. Additional simulated imaging of the 6.13 MeV gamma-rays from 14.1 MeV neutron scattering with water preliminarily demonstrates the imaging capability for high incident energy. (4) Conclusions: We conclude that the prototype has a good imaging performance in a wide energy range (0.3~7 MeV), which shows potential in several MeV gamma-ray imaging applications.

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A Portable Three-Layer Compton Camera for Wide-Energy Range Gamma-Ray Imaging: Design, Simulation and Preliminary Testing

Zhang,

Xiao,

Chen

et al. 2023

Preprint

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(1) Background: The imaging energy range of a typical Compton camera is limited due to the fact that scattered gamma photons are seldom fully absorbed when the incident energies are above 3 MeV. Further improving the upper energy limit of gamma-ray imaging has important application significance in active interrogation of special nuclear materials and chemical warfare agents, as well as range verification of proton therapy; (2) Methods: To realize gamma-ray imag-ing in a wide energy range of 0.3~7 MeV, a principle prototype, named a portable three-layer Compton camera, was developed using the scintillation detector that consist of an silicon photo-multiplier array coupled with a Gd3Al2Ga3O12:Ce pixelated scintillator array. Implemented in a list-mode maximum likelihood expectation maximization algorithm, a far-field energy-domain imaging method based on two-interaction and three-interaction events was applied to estimate the initial energy and spatial distribution of gamma-ray sources. The simulation model of detec-tors was established based on Monte Carlo simulation toolkit Geant4. The reconstructed images of a 133Ba, a 137Cs and a 60Co point-like sources were successfully obtained with our prototype in laboratory tests and compared with simulation studies; (3) Results: The proportion of effective imaging events accounted for about 2%, which made our prototype realize reconstructing the distribution of a 0.05 μSv/h 137Cs source in 10 seconds. The angular resolution for resolving two 137Cs point-like sources was 15°. Additional simulated imaging of the 6.13 MeV gamma-rays from 14.1 MeV neutron scattering with water preliminarily demonstrated the imaging capability for high incident energy; (4) Conclusions: We concluded that the prototype had good imaging per-formance in a wide energy range (0.3~7 MeV), which showed potential in several MeV gam-ma-ray imaging applications.

show abstract

Activation imaging: New concept of visualizing drug distribution with wide-band X-ray and gamma-ray imager

Cited by 3 publications

References 12 publications

Imaging of gamma photons from activated gold wire using a high-energy gamma camera after irradiation of neutrons from boron neutron capture therapy (BNCT) system

Imaging of gamma photons from activated gold wire using a high-energy gamma camera after irradiation of neutrons from boron neutron capture therapy (BNCT) system

A Portable Three-Layer Compton Camera for Wide-Energy-Range Gamma-ray Imaging: Design, Simulation and Preliminary Testing

A Portable Three-Layer Compton Camera for Wide-Energy Range Gamma-Ray Imaging: Design, Simulation and Preliminary Testing

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