Activation by p-chloroamphetamine of the spinal ejaculatory pattern generator in anaesthetized male rats

Pharmacology for the Treatment of Premature Ejaculation

“…Furthermore, in another experimental paradigm of ejaculatory PHARMACOLOGY FOR THE TREATMENT OF PREMATURE EJACULATION reflex (i.e., pudendal motoneuron reflex discharges), 5-HT and the SSRI dapoxetine delivered in the subarachnoidal space at L6-S1 levels were found to enhance this reflex (Clément et al, 2007b). The proejaculatory action of PCA is likely to be mediated by lumbosacral 5-HT2C receptors, with possible potentiation by 5-HT1A receptors (Stafford et al, 2006). Because of the multilevel and multimodal action of spinal 5-HT, defining its precise role in ejaculation is challenging and requires further research.…”

“…Pharmacological competition showed that the primary role in mediating the activity of PCA on ejaculation is played by 5-HT, whereas noradrenaline seems to be of secondary importance (Rènyi, 1985). It is noteworthy that ejaculation was still obtained when PCA was delivered to rats subjected to acute spinal cord complete section at T8-T9 level (Yonezawa et al, 2000;Stafford et al, 2006). Furthermore, in another experimental paradigm of ejaculatory PHARMACOLOGY FOR THE TREATMENT OF PREMATURE EJACULATION reflex (i.e., pudendal motoneuron reflex discharges), 5-HT and the SSRI dapoxetine delivered in the subarachnoidal space at L6-S1 levels were found to enhance this reflex (Clément et al, 2007b).…”

A physiological role for nitric oxide in the centrally mediated sympathetic and somatomotor ejaculatory response in anesthetized male Wistar rats

“…Surgery was then performed to access the VDN for recording as described fully by Stafford et al (2006a). Briefly, a ventral midline incision was made from the base of the sternum as far as the corpus penis, to access the abdomen and viscera.…”

“…administration of pChloroamphetamine (PCA) (Stafford et al, 2006a) or apomorphine (Stafford and Coote 2006). These PCA evoked responses are partly mediated by 5-HT 2C receptors on neurones in the lumbosacral spinal cord (Stafford et al, 2006b).…”

“…Therefore the present study first sought to confirm the distribution and location of NOS positive neurones in the lumbosacral cord and to correlate this with regions considered to play a role in sexual responses. Secondly, using the anaesthetised rat model first described by Stafford et al (2006a) we determined whether NO in the lumbosacral cord participated physiologically in the generation of the spinal ejaculatory pattern of sympathetic and penile muscle response.…”