Activation but not blockade of GABAB receptors during early-life alters anxiety in adulthood in BALB/c mice

Sweeney, Fabian F.; O’Leary, Olivia F.; Cryan, John F.

doi:10.1016/j.neuropharm.2013.08.039

Cited by 14 publications

(6 citation statements)

References 57 publications

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“…These discrepancies between the two studies may be due to the different age of drug exposure. In Study 1 cocaine was administered during PND 68–79, a period that corresponds to the beginning of the adult age (i.e., this age is considered as being “young adulthood or late adolescence”); in contrast, in Study 3 they were treated with cocaine from PND 102 to 113, an age that represents the height of adulthood in mice [41, 43]. It is well known that brain maturation in mammals occurs when the adult age is completely accomplished, as should be the case of the mice from Study 3.…”

Section: Discussionmentioning

confidence: 99%

“…This pattern of EtOH administration in rodents has been used to model the alcohol binge drinking typically observed in adolescent humans, and has been shown to induce long-term behavioral and biochemical alterations in mice [7, 23, 42]. After this treatment regime, animals were left undisturbed for three weeks, until cocaine treatment began on PND 68, an age considered to represent the beginning of adulthood in mice [43]. The procedure of cocaine administration was a variation of that described by Black and colleagues, which has been proven to induce long-lasting alterations in rodent behavior [44–45].…”

Section: Methodsmentioning

confidence: 99%

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Adolescent but not adult ethanol binge drinking modulates cocaine withdrawal symptoms in mice

et al. 2017

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BackgroundEthanol (EtOH) binge drinking is an increasingly common behavior among teenagers that induces long-lasting neurobehavioral alterations in adulthood. An early history of EtOH abuse during adolescence is highly correlated with cocaine addiction in adulthood. Abstinence of cocaine abuse can cause psychiatric symptoms, such as anxiety, psychosis, depression, and cognitive impairments. This study assessed the consequences of adolescent exposure to EtOH on the behavioral alterations promoted by cocaine withdrawal in adulthood.MethodsWe pretreated juvenile (34–47 days old) or adult (68–81 days old) mice with EtOH (1.25 g/kg) following a binge-drinking pattern. Then, after a three-week period without drug delivery, they were subjected to a chronic cocaine treatment in adulthood and tested under cocaine withdrawal by the ensuing paradigms: open field, elevated plus maze, prepulse inhibition, tail suspension test, and object recognition. Another set of mice were treated with the same EtOH binge-drinking procedure during adolescence and were tested immediately afterwards under the same behavioral paradigms.ResultsAdolescent EtOH pretreatment undermined the anxiogenic effects observed after cocaine abstinence, reduced prepulse inhibition, and increased immobility scores in the tail suspension test following cocaine withdrawal. Moreover, the memory deficits evoked by these substances when given separately were enhanced in cocaine-withdrawn mice exposed to EtOH during adolescence. EtOH binge drinking during adolescence also induced anxiety, depressive symptoms, and memory impairments when measured immediately afterwards. In contrast, neither EtOH nor cocaine alone or in combination altered any of these behaviors when given in adulthood.ConclusionsEtOH binge drinking induces short- and long-term behavioral alterations and modulates cocaine withdrawal symptoms when given in adolescent mice.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Adolescent but not adult ethanol binge drinking modulates cocaine withdrawal symptoms in mice

et al. 2017

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“…Marble burying test. The marble burying test measures repetitive and anxiety-like behaviours; the number of marbles buried during the test correlates with anxiety [50]. Clean cages were filled with a 4 cm layer of chipped cedar wood bedding.…”

Section: Ultrasonic Vocalisation Test (Usv)mentioning

confidence: 99%

Early-life oxytocin attenuates the social deficits induced by caesarean-section delivery in the mouse

Morais

Golubeva

Casey

et al. 2021

Neuropsychopharmacol.

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The oxytocin (OXT) system has been strongly implicated in the regulation of social behaviour and anxiety, potentially contributing to the aetiology of a wide range of neuropathologies. Birth by Caesarean-section (C-section) results in alterations in microbiota diversity in early-life, alterations in brain development and has recently been associated with long-term social and anxiety-like behaviour deficits. In this study, we assessed whether OXT intervention in the early postnatal period could reverse C-section-mediated effects on behaviour, and physiology in early life and adulthood. Following C-section or per vaginum birth, pups were administered with OXT (0.2 or 2 μg/20 μl; s.c.) or saline daily from postnatal days 1–5. We demonstrate that early postnatal OXT treatment has long-lasting effects reversing many of the effects of C-section on mouse behaviour and physiology. In early-life, high-dose OXT administration attenuated C-section-mediated maternal attachment impairments. In adulthood, low-dose OXT restored social memory deficits, some aspects of anxiety-like behaviour, and improved gastrointestinal transit. Furthermore, as a consequence of OXT intervention in early life, OXT plasma levels were increased in adulthood, and dysregulation of the immune response in C-section animals was attenuated by both doses of OXT treatment. These findings indicate that there is an early developmental window sensitive to manipulations of the OXT system that can prevent lifelong behavioural and physiological impairments associated with mode of birth.

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“…Stress-induced hyperthermia (SIH) is obvious in animals and may complicate data interpretation when ignored. SIH animal models have been developed for the evaluation of anxiolytic drugs (O’Connor et al, 2013; Sweeney et al, 2014; Vinkers et al, 2010). In our studies, SIH was more transient and the onset of SIH was much faster than 5-MeO-DMT-induced hyperthermia, as indicated by the ΔCBT profiles (Figure 2 and Figure 3).…”

Section: Discussionmentioning

confidence: 99%

Potentiation of 5-methoxy-N,N-dimethyltryptamine-induced hyperthermia by harmaline and the involvement of activation of 5-HT1A and 5-HT2A receptors

Jiang

Shen

2015

Neuropharmacology

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5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) and harmaline are serotonin (5-HT) analogs often abused together, which alters thermoregulation that may indicate the severity of serotonin toxicity. Our recent studies have revealed that co-administration of monoamine oxidase inhibitor harmaline leads to greater and prolonged exposure to 5-HT agonist 5-MeO-DMT that might be influenced by cytochrome P450 2D6 (CYP2D6) status. This study was to define the effects of harmaline and 5-MeO-DMT on thermoregulation in wild-type and CYP2D6-humanized (Tg-CYP2D6) mice, as well as the involvement of 5-HT receptors. Animal core body temperatures were monitored noninvasively in the home cages after implantation of telemetry transmitters and administration of drugs. Harmaline (5 and 15 mg/kg, i.p.) alone was shown to induce hypothermia that was significantly affected by CYP2D6 status. In contrast, higher doses of 5-MeO-DMT (10 and 20 mg/kg) alone caused hyperthermia. Co-administration of harmaline (2, 5 or 15 mg/kg) remarkably potentiated the hyperthermia elicited by 5-MeO-DMT (2 or 10 mg/kg), which might be influenced by CYP2D6 status at certain dose combination. Interestingly, harmaline-induced hypothermia was only attenuated by 5-HT1A receptor antagonist WAY-100635, whereas 5-MeO-DMT- and harmaline-5-MeO-DMT-induced hyperthermia could be suppressed by either WAY-100635 or 5-HT2A receptor antagonists (MDL-100907 and ketanserin). Moreover, stress-induced hyperthermia under home cage conditions was not affected by WAY-100635 but surprisingly attenuated by MDL-100907 and ketanserin. Our results indicate that co-administration of monoamine oxidase inhibitor largely potentiates 5-MeO-DMT-induced hyperthermia that involves the activation of both 5-HT1A and 5-HT2A receptors. These findings shall provide insights into development of anxiolytic drugs and new strategies to relieve the lethal hyperthermia in serotonin toxicity.

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Activation but not blockade of GABAB receptors during early-life alters anxiety in adulthood in BALB/c mice

Cited by 14 publications

References 57 publications

Adolescent but not adult ethanol binge drinking modulates cocaine withdrawal symptoms in mice

Adolescent but not adult ethanol binge drinking modulates cocaine withdrawal symptoms in mice

Early-life oxytocin attenuates the social deficits induced by caesarean-section delivery in the mouse

Potentiation of 5-methoxy-N,N-dimethyltryptamine-induced hyperthermia by harmaline and the involvement of activation of 5-HT1A and 5-HT2A receptors

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