Activation Analysis

Bowen, H. J. M.

doi:10.1007/978-1-4613-4401-8_7

Cited by 4 publications

(5 citation statements)

References 75 publications

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“…After this decay period, we performed spectrographic analysis to measure the concentration of the resultant radioactive nuclei in each vial. The general principles used to determine the elemental mass in each sample after neutron activation are outlined in the APPENDIX (3).…”

Section: Methodsmentioning

confidence: 99%

“…Neutron activation analysis can provide researchers with capabilities not readily avail-able with other assay technologies. Neutron activation is well known for its high sensitivity and elemental specificity for the simultaneous measurement of trace elements (1,3,7,15,20,29,31). This offers the poten- tial of being able to measure multiple isotopic tracers per assay.…”

Section: H111mentioning

confidence: 99%

“…Unlike optical lasers, neutrons can penetrate solid tissue and opaque-liquid samples, thereby providing an assay that is completely self-contained and requires minimal sample preparation. Unlike other element detection methods, such as atomic absorption spectrophotometry, neutron activation is not chemically or physically destructive (3,9). Therefore, samples can be archived, reassayed, and/or undergo additional analysis after neutron activation.…”

Section: H111mentioning

confidence: 99%

“…One potential approach is the use of stable isotopic tracers that can be assayed by neutron activation. Neutron activation is a well-known analytic technique whereby neutrons penetrate the sample and activate elements within the sample (1,3,7,15,20,29,31). After activation, elements of interest within the sample are rendered radioactive and can be quantified using high-resolution radiation counting equipment.…”

Section: Since Its Introduction In 1967 the Radioactive Micro-mentioning

confidence: 99%

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Stable labeled microspheres to measure perfusion: validation of a neutron activation assay technique

Reinhardt

Dalhberg

Tries

et al. 2001

American Journal of Physiology-Heart and Circulatory Physiology

122

109

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Neutron activation is an accurate analytic method in which trace quantities of isotopes of interest in a sample are activated and the emitted radiation is measured with high-resolution detection equipment. This study demonstrates the application of neutron activation for the measurement of myocardial perfusion using stable isotopically labeled microspheres. Stable labeled and standard radiolabeled microspheres (15 microm) were coinjected in an in vivo rabbit model of myocardial ischemia and reperfusion. Radiolabeled microspheres were detected with a standard gamma-well counter, and stable labeled microspheres were detected with a high-resolution Ge detection after neutron activation of the myocardial and reference blood samples. Regional myocardial blood flow was calculated from the deposition of radiolabeled and stable labeled microspheres. Both sets of microspheres gave similar measurements of regional myocardial blood flow over a wide range of flow with a high linear correlation (r = 0.95-0.99). Neutron activation is capable of detecting a single microsphere in an intact myocardial sample while providing simultaneous quantitative measurements of multiple isotope labels. This high sensitivity and capability for measuring perfusion in intact tissue are advantages over other techniques, such as optical detection of microspheres. Neutron activation also can provide an effective method for reducing the production of low-level radioactive waste generated from biomedical research. Further applications of neutron activation offer the potential for measuring other stable labeled compounds, such as fatty acids and growth factors, in conjunction with microsphere measured flow, providing the capability for simultaneous measurement of regional metabolism and perfusion.

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Section: Methodsmentioning

confidence: 99%

Section: H111mentioning

confidence: 99%

Section: H111mentioning

confidence: 99%

Section: Since Its Introduction In 1967 the Radioactive Micro-mentioning

confidence: 99%

See 2 more Smart Citations

Stable labeled microspheres to measure perfusion: validation of a neutron activation assay technique

Reinhardt

Dalhberg

Tries

et al. 2001

American Journal of Physiology-Heart and Circulatory Physiology

122

109

View full text Add to dashboard Cite

show abstract

“…* For readers not familiar with the method of neutron activation analysis it should be pointed out that these apparently different treatments of skin samples from abdominal wall and from foot were entirely comparable (seeBowen, 1975).…”

mentioning

confidence: 99%