Activating MC4R Promotes Functional Recovery by Repressing Oxidative Stress-Mediated AIM2 Activation Post-spinal Cord Injury

Wang, Yongli; Fang, Nongtao; Wang, Yikang; Geng, Yibo; Li, Yao

doi:10.1007/s12035-024-03936-9

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The Roles Of Aim2 In Neurodegenerative Diseases1

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2024

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“…Meanwhile, Schwann cell (SC) therapy has exhibited greater efficacy in dampening AIM2 inflammasome activation and the associated inflammatory pathway in SCI compared to Wharton’s jelly mesenchymal stem cells (WJ-MSCs) ( 73 ). Additionally, melanocortin receptor 4 (MC4R) has shown a protective effect on neurons by inhibiting AIM2 activation post-SCI, partly attributed to its regulation of mitochondrial homeostasis ( 74 ).…”

Section: The Roles Of Aim2 In Neurodegenerative Diseasesmentioning

confidence: 99%

The roles of AIM2 in neurodegenerative diseases: insights and therapeutic implications

Yang,

Wang,

Pan

et al. 2024

Front. Immunol.

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AIM2, a cytosolic innate immune receptor, has the capability to recognize double-stranded DNA (dsDNA). This paper delineates the structural features of AIM2 and its mechanisms of activation, emphasizing its capacity to detect cytosolic DNA and initiate inflammasome assembly. Additionally, we explore the diverse functions of AIM2 in different cells. Insights into AIM2-mediated neuroinflammation provide a foundation for investigating novel therapeutic strategies targeting AIM2 signaling pathways. Furthermore, we present a comprehensive review of the roles of AIM2 in neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD). Finally, we discuss its therapeutic implications. In conclusion, a profound understanding of AIM2 in neurodegenerative diseases may facilitate the development of effective interventions to mitigate neuronal damage and slow disease progression.

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Section: The Roles Of Aim2 In Neurodegenerative Diseasesmentioning

confidence: 99%