Activating blood circulation to remove stasis treatment of hypertensive intracerebral hemorrhage: A multi-center prospective randomized open-label blinded-endpoint trial

Abstract

The integrative therapy combined TRABC with conventional Western treatment for HICH could promote hematoma absorption thus minimize neurologic impairment, without increasing intracerebral hematoma expansion and re-bleeding.

Efficacy and Safety of Chinese Herbal Medicine for Primary Intracerebral Hemorrhage: A Systematic Review of Randomized Controlled Trials

“…Nineteen studies reported follow-up from 7 days to 1 year. The follow-up time over 3 months was reported in 18 studies (Jia et al, 2000; Dai et al, 2002; Huang et al, 2006; Chen et al, 2010; Huang et al, 2010; Wang and Wang, 2011; Li et al, 2012; Shen et al, 2012; Zhang et al, 2012; Ming et al, 2013; Wang et al, 2013; Ye, 2014; Li et al, 2015; Li and Wu, 2016; Liu and Zhang, 2016; Xia et al, 2016; Ma and Zhang, 2017). Mortality rate was observed in 14 studies; dependence in 10 studies; clinical effective rate in 28 studies; neurological deficit score in 37 studies; VH in 23 studies; VPE in 7 studies; and adverse events in 16 studies.…”

“…There were 4,517 participants of Chinese ethnicity that were included in the 45 studies, of which 2,267 patients were treatment groups and 2,250 patients served as controls. Forty-two studies (Fan et al, 2000; Jia et al, 2000; Dai et al, 2002; Ma and Gong, 2005; Yang and Liu, 2006; Fan et al, 2008; Sun and Chen, 2008; Huang et al, 2010; Liao et al, 2010; Ming et al, 2010; Chen, 2011; Li et al, 2011; Peng et al, 2011; Wang and Wang, 2011; Li et al, 2012; Shen et al, 2012; Zhang et al, 2012; Ming et al, 2013; Wang et al, 2013; Bi and Hu, 2014; Gu et al, 2014; Guo et al, 2014; Li, 2014; Ye, 2014; Guan et al, 2015; Li et al, 2015; Luo et al, 2015; Peng and Feng, 2015; Shen and Luo, 2015; Guo et al, 2016; Jiang et al, 2016; Li et al, 2016; Liu and Wu, 2016; Liu and Zhang, 2016; Long et al, 2016; Shang and Yang, 2016; Xia et al, 2016; Zhou et al, 2016; Lei and Qiao, 2017; Ma and Zhang, 2017; Sun et al, 2017; Zhang et al, 2017) compared CHM plus WCM with WCM alone, and three studies (Huang et al, 2006; Chen et al, 2010; Liu et al, 2012) compared CHM plus WCM with CHM placebo plus WCM. The CHM treatment course varied from 7 to 90 days.…”

“…The total scores according to Cochrane risk of bias ( Table 1 ) are as follows: Xia et al (2016) with 7 points; Chen et al (2010) and Li et al(2016) with 6 points; Huang et al (2006) and Luo et al (2015) with 5 points; the other 40 RCTs with 4 points. The method of random distribution was clearly proposed in all included documents.…”

“…The method of random distribution was clearly proposed in all included documents. In addition, three studies (Chen et al, 2010; Li et al, 2016; Xia et al, 2016) explicitly proposed the method of distribution concealment; two studies (Chen et al, 2010; Xia et al, 2016) had double blinding for the implementers and participants; and four studies (Huang et al, 2006; Luo et al, 2015; Li et al, 2016; Xia et al, 2016) evaluated the outcome indexes by blind method.…”

“…Ten studies (Jia et al, 2000; Dai et al, 2002; Huang et al, 2006; Chen et al, 2010; Wang and Wang, 2011; Li et al, 2012; Liu et al, 2012; Li et al, 2016; Xia et al, 2016; Ma and Zhang, 2017) used the dependency as outcome measure. Three studies showed that CHM plus WCM was significant for reducing the dependence according to BI (Huang et al, 2006); combined use of mRS and BI (Chen et al, 2010) and home-made comparable scale (Liu et al, 2012) compared with CHM placebo plus WCM (P < 0.05).…”