Activated T Lymphocytes in Pre‐Eclampsia

Abstract

The increased levels of T CD4(+)45RO(+) and T CD8(+) CD25(+) cells can suggest the activation of CD4(+) and CD8(+) T lymphocytes in pre-eclampsia. It seems possible that the activation of T lymphocytes is associated with the deficiency of T regulatory cells in PE.

Preeclampsia is Associated with Lower Percentages of Regulatory T Cells in Maternal Blood

“…Several studies have been published describing an association between a decreased level of Treg cells in peripheral blood and preeclampsia, however the methods and results are not consistent (22)(23)(24)(25)(26). Furthermore, most of these studies used CD25 as a Treg cell marker.…”

Regulatory T Helper Cells in Pregnancy and their Roles in Systemic versus Local Immune Tolerance

“…When defined as CD4 + CD25 + ⁄ high , preeclamptic women showed reduced circulating Treg numbers 110,111 or levels similar 112,113 to those of healthy pregnant women. Studies using FOXP3 protein as Treg marker support the notion of reduced Treg numbers 88,[114][115][116] in preeclampsia.…”

Immunologically Mediated Male and Female Reproductive Failure

“…In addition, during normal pregnancies, the numbers of Treg cells are increased in the peripheral blood as well as at the maternal-fetal interface (Heikkinen et al, 2004;Sasaki et al, 2004;Somerset et al, 2004); however, during preeclampsia the numbers of Treg cells are reduced at the maternal-fetal interface and in the peripheral blood (Sasaki et al, 2007;Darmochwal-Kolarz et al, 2007). The proinflammatory CD4 + Th17 cell population is decreased during healthy pregnancy but increased in women with preeclampsia (Santner-Nanan et al, 2009).…”