Activated Salivary MMP-2 - A Potential Breast Cancer Marker

Bhattacharyya, Nabanita; Mondal, Subhajit; Ali, Mohammad Nasim; Mukherjee, Ramanuj; Adhikari, Anjan; Chatterjee, Amitava

doi:10.2174/2210289201708010022

Cited by 4 publications

(8 citation statements)

References 37 publications

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“…The biomarkers present in blood and urine can also be detected in a sample of saliva (Bhattacharyya et al, 2017). It has been reported by Pammer et al (Pammer et al, 1998) and Taichman et al (Taichman et al, 1998), the presence of VEGF in saliva of healthy individual.…”

Section: Introductionmentioning

confidence: 80%

“…The immublot of salivary proteins of breast cancer patients show that the 45kD VEGF has been processed to 22 kD band ( Figure 3). So increase of VEGF and MMP-2 expression & activity in saliva of breast cancer patients perhaps indicate the interdependence of MMP-2 and VEGF (Walt et al, 2007;Bhattacharyya et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…The NC paper was blocked with BSA and reacted with anti VEGF, MMP-9 or MMP-2 antibody followed by secodary antibody coupled to alkaline phosphatase. The colour was developed by NBT/BCIP (Bhattacharyya et al, 2017). Figure 1 A clearly shows that salivary VEGF were much higher in breast cancer patients compare to non breast cancer patients.…”

Section: Immunoblotmentioning

confidence: 99%

“…The wells were washed and colour was developed by TMB. The colour was read at 450 nM (Bhattacharyya et al, 2017).…”

Section: Elisamentioning

confidence: 99%

“…The gel was then incubated in buffer (NaCl 0.2M, CaCl2 4.5 mM, Tris 50mM, pH 7.4) keeping at 37°C for 15 hrs. The gel was then stained with Coommassiee Brilliant blue to detect the bands (Bhattacharyya et al, 2017).…”

Section: Substrate Zymographymentioning

confidence: 99%

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Salivary VEGF - A Potential Breast Cancer Marker

Mondal¹,

Santra²,

Ali³

et al. 2018

CCO

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Section: Introductionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Immunoblotmentioning

confidence: 99%

“…The wells were washed and colour was developed by TMB. The colour was read at 450 nM (Bhattacharyya et al, 2017).…”

Section: Elisamentioning

confidence: 99%

Section: Substrate Zymographymentioning

confidence: 99%

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Salivary VEGF - A Potential Breast Cancer Marker

Mondal¹,

Santra²,

Ali³

et al. 2018

CCO

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Biosynthesis and Chemopreventive Potential of Jute (Corchorus capsularis and C. olitorius) Flavonoids and Phylogeny of Flavonoid Biosynthesis Pathways

Satya

Sarkar

Chatterjee

et al. 2022

Planta Medica International Open

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Flavonoids are valuable phytochemicals for human health and nutrition. Jute (Corchorus capsularis and C. olitorius), a vegetable rich in phenolics and flavonoids, is globally consumed for its health benefit, but the biosynthesis pathways and metabolic profiles of its flavonoids are poorly characterized. Elucidating the flavonoid biosynthesis pathways would augment the broader use of jute, including targeted synthesis of its specific flavonoids. We reconstructed the core flavonoid biosynthesis pathways in jute by integrating transcriptome mining, HPLC and flavonoid histochemistry. In C. capsularis (white jute), the flavonoid biosynthesis pathways’ metabolic flux was driven toward the biosynthesis of proanthocyanidins that mediate the acquisition of abiotic stress tolerance. However, higher levels of flavonols in C. olitorius (tossa jute) render it more suitable for nutritional and medicinal use. Jute flavonoid extract exhibited in vitro inhibition of matrix metalloproteinase-2, suggesting its potential chemopreventive and immunity-boosting roles. Using the flavonoid biosynthesis pathways profiles of 93 plant species, we reconstructed the flavonoid biosynthesis pathways phylogeny based on distance-based clustering of reaction paths. This reaction-path flavonoid biosynthesis pathways phylogeny was quite distinct from that reconstructed using individual gene sequences. Our flavonoid biosynthesis pathways-based classification of flavonoid groups corroborates well with their chemical evolution, suggesting complex, adaptive evolution of flavonoid biosynthesis pathways, particularly in higher plants.

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