Activated Platelets Jam Up the Plaque

Adrover, José M.; Hidalgo, Andrés

doi:10.1161/circresaha.115.305823

Cited by 4 publications

(1 citation statement)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increased lipoprotein(a) levels are associated with the risk of future cardiovascular disease events [ 23 ]. Activated blood platelets, in turn, may promote atherosclerosis [ 24 ]. Moreover, peripheral blood eosinophilia is a predictor factor for death from coronary heart diseases and cerebrovascular diseases [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Asthma is associated with atherosclerotic artery changes

et al. 2017

View full text Add to dashboard Cite

Asthma is a chronic airway inflammation with a potential systemic impact. Atherosclerosis is a chronic inflammatory artery disease. The aim of our study was to prove if there is a correlation between the occurrence of asthma and increased atherosclerotic vessel disorders. Vessel status was compared between mild-to-moderate, severe allergic asthma and matched controls. Measurements of artery stiffness were calculated by central pulse wave velocity, ultrasonographic strain imaging and ankle-brachial index. Atherosclerotic plaque burden was assessed by colour-coded duplex sonography. Additionally, analysis of cardiovascular and asthma blood markers was conducted. Arterial stiffness expressed as an increased central pulse wave velocity and decreased circumferential and radial strains as well as the prevalence of media sclerosis were significantly higher among asthma patients compared to controls. Atherosclerotic plaque burden was relevantly increased in asthma groups vs. controls (severe asthma: 43.1%, mild-to-moderate asthma: 25.0%, control: 14.3% of study participants). Except for the elevated IgE and fibrinogen concentrations as well as leukocyte number there were no relevant differences in the blood parameters between the groups. Allergic asthma is associated with distinct atherosclerotic artery changes compared to the respectively matched control collective. The severity of asthma correlates with more pronounced pathological vessel alternations.

show abstract

Section: Discussionmentioning

confidence: 99%