Activated Platelet-Rich Plasma Improves Fat Graft Survival in Nude Mice: A Pilot Study

Abstract

PRP treatment improved the survival and quality of fat grafts. Safer methods of PRP activation and preparation should be further investigated for potential application in humans.

Application of Platelet-Rich Plasma and Platelet-Rich Fibrin in Fat Grafting: Basic Science and Literature Review

“…Oh et al mixed human lipoaspirated fat graft and activated PRP (by thrombin and CaCl 2 ) at a ratio of 7:2 and implanted it on the scalps of nude mice. 18 They found higher PRP volume and weight in the control group after 10 weeks. The histology was analyzed, but only with a semiquantitative method with a grading scale.…”

“…Although some successful clinical results were reported, 16,17 evidence supporting the application of PRP combined with fat grafts in soft tissue augmentation remains limited, as only a few basic research and preclinical studies in small animals have been conducted. 15,[18][19][20][21][22][23] Furthermore, no details on molecular mechanisms are addressed in the literature. In this review article, we discuss the possible molecular mechanisms of PRP in fat graft survival based on a review of the current literature.…”

The Wonder Tool Platelet Rich Plasma in Cosmetic Dermatology, Trichology and Hair Transplant

“…Fat graft volume and weight were found to be significantly higher in the PRP group than in the control group. Histologic evaluation showed greater vascularity, fewer cysts and vacuoles, and lesser fibrosis in the PRP group [27].…”

Efficacy of Platelet-Rich Plasma on Fat Grafts in the Repair of Tympanic Membrane Perforations: An Experimental Study

“…Because of this, PRP is frequently used today in craniofacial, orthopedic, and neurological surgery [8][9][10][11] . PRP increases the success of grafting when fat grafts are applied in various regions of the body [11][12][13][14] . Moreover, Erkilet et al [15] showed positive effects of PRP when used on its own on the tympanic membrane.…”