2003
DOI: 10.1073/pnas.1633689100
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Activated integrin αvβ3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells

Abstract: Expression of adhesion receptor integrin ␣v␤3 in an activated functional form strongly promotes metastasis in human breast cancer cells. Here, we report that ␣v␤3 cooperates with matrix metalloproteinase type 9 (MMP-9) in breast cancer cell migration. This cooperation is regulated by the activation state of the integrin. Expression of activated ␣v␤3 in metastatic variants of MDA-MB 435 human breast cancer cells and primary metastatic cells from breast cancer patients strongly enhanced migration toward vitronec… Show more

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Cited by 287 publications
(271 citation statements)
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“…Many reports indicated that in Akt signaling, pAkt, NF-jB, EGF, VEGF, VEGFR1, MMP-9 and MMP-2 play important roles in promoting proliferation, migration, invasion, angiogenesis, and metastasis of cancer cells (Price et al 1999;Helbig et al 2003;Rolli et al 2003;Koivunen et al1999;Kletsas et al 2000;John and Tuszynski 2001;Shibata et al 2002;Gibson et al 2002;Lee et al 2007). Thus, we next investigated if the suppression of the cancer cell shown as mean ± SD is relative to that of 0 lg/mL (0.1% DMSO vehicle) or 0 h as the control (designated as 100%).…”
Section: Resultsmentioning
confidence: 99%
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“…Many reports indicated that in Akt signaling, pAkt, NF-jB, EGF, VEGF, VEGFR1, MMP-9 and MMP-2 play important roles in promoting proliferation, migration, invasion, angiogenesis, and metastasis of cancer cells (Price et al 1999;Helbig et al 2003;Rolli et al 2003;Koivunen et al1999;Kletsas et al 2000;John and Tuszynski 2001;Shibata et al 2002;Gibson et al 2002;Lee et al 2007). Thus, we next investigated if the suppression of the cancer cell shown as mean ± SD is relative to that of 0 lg/mL (0.1% DMSO vehicle) or 0 h as the control (designated as 100%).…”
Section: Resultsmentioning
confidence: 99%
“…MMP-9 is a NF-jB-regulated gene. MMP-9 and MMP-2 are not only associated with invasion and metastasis but also MMP-9 and VEGF have been implicated in angiogenesis, and hence they are considered to be the therapeutic targets of high priority (Rolli et al 2003;Koivunen et al 1999;Mitropoulou et al 2003).…”
Section: Resultsmentioning
confidence: 99%
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“…20,21 The expression of av and b3 subunits in B16 cells was reduced in the presence of IFN-g, whereas they were increased 24 h after the removal of IFN-g (Fig. 5a).…”
Section: Avb3 Signaling Is Intensified After the Withdrawal Of Ifn-cmentioning
confidence: 97%
“…Although two later case -control studies did not confirm an increased risk of invasive breast cancer among Leu33Pro homozygotes (Ayala et al, 2003;Jin et al, 2004), certain considerations nevertheless favour the possibility that the ITGB3 Leu33Pro polymorphism may influence risk of invasive breast cancer. First, beta 3 integrins are ectopically expressed on breast carcinoma cells where they enhance invasive and metastasiogenic properties of these cells (Murthy et al, 1996;Wewer et al, 1997;Chen et al, 2001Chen et al, , 2004Rolli et al, 2003). Second, the Pro33 vs Leu33 allele enhances integrin-mediated activation of MAPK pathways (Vijayan et al, 2003), crucial for the malignant potential of cancer cells (Johnson and Lapadat, 2002).…”
mentioning
confidence: 99%