Activated hepatic stellate cells overexpress p75NTR after partial hepatectomy and undergo apoptosis on nerve growth factor stimulation

Abstract

Although activated HSCs may produce the factors that regulate liver regeneration, the de novo NGF production by regenerating hepatocytes may induce the death of activated HSCs via p75NTR, leading to termination of hepatic regeneration.

Histopathologic and immunohistochemical lesions in liver of mink infected with Aleutian disease virus

“…The main function of MMP is degradation of extracellular matrix (Hanumegowda et al 2003) as a result the exchange of gases and substances between blood and hepatocytes is considerably mitigated (Kelly 1993, Klatskin andConn 1993). The lack of correlation of MMP-2 with any groups of inflammation intensity observed by us could be explained by the fact that although neutrophilic leukocytes are a significant source of reactive oxygen species (Thannickal and Fanburg 2000), still an activated neutrohil produces also oxygen monoxide, which in an opposite case reduces the initial discharging of peroxide in cells blocking MMP-2 secretion and reducing formation of fibrosis in liver (Asai 2006). Arthur (1998) has also made a similar observation, stating that there was little gelatinase A in a healthy liver but it dramatically increased in case of liver diseases.…”

IFATS Collection: In Vivo Therapeutic Potential of Human Adipose Tissue Mesenchymal Stem Cells After Transplantation into Mice with Liver Injury

“…Recently, G-CSF has been shown to promote rat liver repair and induce oval cell migration and proliferation [48,49]; however, there are controversial opinions regarding the G-CSF effect [50]. Recent evidence suggests that neurotrophins, such as NGF, may have a role in hepatic regeneration [51][52][53][54][55], and their mRNA and protein levels become elevated in association with hepatocyte proliferation induced by, for example, administration of CCl 4 [52]. NGF, similarly to HGF, induces the apoptosis of stellate cells [52][53][54].…”

Hepatic Stellate Cell-derived Delta-like Homolog 1 (DLK1) Protein in Liver Regeneration

“…Liver regeneration induced by partial hepatectomy (PH) is associated with the loss of HSC-associated vitamin A content (13) and up-regulation of the HSC activation markers such as ␣-smooth muscle actin (␣SMA), IL-6, and hepatocyte growth factor (14), suggesting that HSCs undergo activation and support a regenerative response. Regulation of HSC myofibroblastic activation by the neurotrophin receptor p75NTR is actually crucial for supporting liver regeneration (10).…”