Activated Factor X delivered by Adeno-Associated virus significantly inhibited bleeding and alleviated hemophilia A/B arthropathy in hemophilia mice
Xia Wu,
Feixu Zhang,
Xinyue Zhou
et al.
Abstract:In hemophilia, deficient factor VIII or IX in hemophilia prevents activation of the common coagulation pathway, inhibiting conversion of FX to activated FXa required for thrombin generation. We hypothesized that delivering FXa could activate the common pathway and restore coagulation in hemophilia patients. In this study, we tried to deliver FXa by adeno-associated virus (AAV) for treating hemophilia and hemophilic arthropathy. The cassettes that expressed FXa, FXa (FXaop) and FXa-FVII was constructed and were… Show more
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