Activated factor IX, factor XI and tissue factor identify patients with permanent atrial fibrillation treated with warfarin who are at risk of ischemic stroke

Kusak, Piotr; Czarnecka, Danuta; Gissel, Matthew; Plens, Krzysztof; Butenas, Saulius; Undas, Anetta

doi:10.5114/aoms.2015.54791

Cited by 14 publications

(19 citation statements)

References 35 publications

(35 reference statements)

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“…The absence of a clearly defined relationship or correspondence of FIXa to either injury severity and/or shock is consistent with a previous study that suggested the mechanism of regulating FIXa generation and longevity differs from those observed for TF and FXIa. 50 …”

Section: Discussionmentioning

confidence: 99%

Correlation between factor (F)XIa, FIXa and tissue factor and trauma severity

Prior

Cohen

Conroy

et al. 2017

Journal of Trauma and Acute Care Surgery

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BACKGROUND It has been observed that trauma patients often display elevated procoagulant activity that could be caused, in part, by tissue factor (TF). We previously observed that trauma patients with thermal, blunt and penetrating injuries have active FIXa and FXIa in their plasma. In the current study we evaluated the effect of injury severity, with or without accompanying shock, on the frequency and concentration of TF, FIXa and FXIa in plasma from trauma patients. METHODS Eighty trauma patients were enrolled and divided equally into 4 groups based on their injury severity score (ISS) and base deficit (BD): Group 1: Non-severe injury, no shock Group 2: Non-severe injury, with shock Group 3: Severe injury, no shock Group 4: Severe injury, with shock Blood was collected at a 0 time-point (first blood draw upon arrival at hospital) and citrate plasma was prepared, frozen and stored at −80C. FXIa, FIXa and TF activity assays were based on a response of thrombin generation to corresponding monoclonal inhibitory antibodies. RESULTS The frequency and median concentrations of TF were relatively low in non-severe injury groups (17.5 % and 0 pM respectively) but were higher in those with severe injury (65% and 0.5 pM, respectively). While FXIa was observed in 91% of samples and was high across all 4 groups, median concentrations were highest (by approximately 4-fold) in groups with shock. FIXa was observed in 80% of plasma samples and concentrations varied in a relatively narrow range between all 4 groups. No endogenous activity was observed in plasma from healthy individuals. CONCLUSIONS 1) Frequency and concentration of TF is higher in patients with a higher trauma severity; 2) Concentration of FXIa is higher in patients with shock; 3) For the first time reported, the vast majority of plasma samples from trauma patients contain active FIXa and FXIa. LEVEL of EVIDENCE Diagnostic Tests or Criteria, level I. Diagnostic Tests.

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Section: Discussionmentioning

confidence: 99%

Correlation between factor (F)XIa, FIXa and tissue factor and trauma severity

Prior

Cohen

Conroy

et al. 2017

Journal of Trauma and Acute Care Surgery

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“…Twenty-five studies were excluded by reading the text of the article: 6 studies were not related to AF or prognosis of AF, 4 studies lacked any of our requisite data, 3 studies were not used for assessment of vWF and 12 were not prospective cohort studies. Finally, 12 studies were included 21 25 28–35 39–41. A flow diagram of our search for articles is shown in figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…Eight studies21 28–31 33 40 41 reported correlations between vWF levels and stroke. Meta-analysis showed that six studies21 28–31 33 with a follow-up of ≥3 years found that high vWF levels did not increase the risk of stroke in patients with AF (RR 1.64; 95% CI 0.98 to 2.76), but two studies40 41 with a follow-up of <3 years found that high vWF levels increased the risk of stroke in AF patients (RR 1.8; 95% CI 1.09 to 2.98) (figure 5A).…”

Section: Resultsmentioning

confidence: 99%

“…However, the results are still controversial. Studies have shown that patients with AF with higher plasma vWF levels have a higher risk of an adverse prognosis,27–32 but some studies suggest that high vWF levels do not increase the risk of an adverse prognosis in AF patients 33–35. A recent meta-analysis36 showed that, in patients with AF, elevated vWF levels are associated with a higher risk of major adverse cardiac events (MACE) and all-cause mortality, but other risks such as cardiovascular death, stroke and bleeding events have not been studied.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic value of von Willebrand factor for patients with atrial fibrillation: a meta-analysis of prospective cohort studies

Chang

Wang

et al. 2019

Postgraduate Medical Journal

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BackgroundIt is unknown whether an abnormal level of von Willebrand factor (vWF) is correlated with the prognosis of patients with atrial fibrillation (AF) and current findings are controversial. This meta-analysis aimed to evaluate the association between vWF levels and the clinical prognosis of patients with AF.MethodsWe searched prospective cohort studies on PubMed, Embase, Web of Science, Cochrane Library and WanFang databases for vWF and adverse events of AF from inception of the databases to July 2019. The risk ratios of all-cause death, cardiovascular death, major adverse cardiac events (MACE), stroke and bleeding prognosis in patients with AF were analysed using a fixed-effects model or random-effects model, and all included studies were evaluated with heterogeneity and publication bias analysis.ResultsTwelve studies which included 7449 patients with AF were used in the meta-analysis. The average age was 71.3 years and the average follow-up time was 3.38 years. The analysis found that high vWF levels were associated with increased risks of all-cause death (RR 1.56; 95% CI 1.16 to 2.11, p=0.00400), cardiovascular death (RR 1.91; 95% CI 1.20 to 3.03, p=0.00600), MACE (RR 1.83; 95% CI 1.28 to 2.62, p=0.00090), stroke (RR 1.69; 95% CI 1.08 to 2.64, p=0.02000) and bleeding (RR 2.01; 95% CI 1.65 to 2.45, p<0.00001) in patients with AF.ConclusionsvWF is a risk factor for poor prognosis of AF, and patients with higher vWF levels have a higher risk of all-cause death, cardiovascular death, MACE, stroke and bleeding.

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“…Particular attention should be paid to the group of patients with cardiovascular disease, e.g. permanent atrial fibrillation, who present chronic changes in haemostasis and higher thromboembolic risk [24].…”

Section: Von Willebrand Factormentioning

confidence: 99%

Evaluation of selected parameters of the coagulation system during the perioperative period in patients undergoing endoscopic surgery of the paranasal sinuses

Urbaniak¹,

Owczarek²,

Miłoński³

et al. 2020

aoms

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A b s t r a c tIntroduction: The aim of the study was to evaluate selected parameters of the coagulation system during the perioperative period in patients undergoing endoscopic sinus surgery. Material and methods: The study involved 121 patients: group I -42 patients who did not receive anticoagulatory or antiplatelet medications, qualified for endoscopic sinus surgery under total intravenous anaesthesia (TIVA); group II -40 patients who received in the perioperative period low-molecular-weight heparins, qualified for endoscopic sinus surgery under TIVA; group III -39 patients diagnosed according to a schedule, due to vertigo or loss of hearing. All the patients received a full laryngological examination and detailed audiological and otoneurological diagnostics, and examination of selected haemostatic parameters before the surgery/diagnostics. Results: The analysis of concentrations of coagulation parameters in groups I and II revealed a statistically significantly higher international normalized ratio value before surgery (I -1.11; II -1.08) and 48 h following surgery (I -1.15; II -1.10) in group I. The concentration of coagulation factor VII in the study patients was considerably higher in group I for all three measurements (481.93; 443.13; 486.02). The concentration of fibrinogen (coagulation factor I) was significantly lower in group I before surgery (3.2) and at 6 h after surgery (2.84). A significantly lower level of von Willebrand factor was found in group I before surgery (2.94). Comparing test results of groups I and III, who did not receive antiaggregants, statistically significant differences were observed in both tests for factors VII and VIII. Conclusions: Concentrations of von Willebrand factor and prothrombin revealed statistically significant differences in between groups.

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Activated factor IX, factor XI and tissue factor identify patients with permanent atrial fibrillation treated with warfarin who are at risk of ischemic stroke

Cited by 14 publications

References 35 publications

Correlation between factor (F)XIa, FIXa and tissue factor and trauma severity

Correlation between factor (F)XIa, FIXa and tissue factor and trauma severity

Prognostic value of von Willebrand factor for patients with atrial fibrillation: a meta-analysis of prospective cohort studies

Evaluation of selected parameters of the coagulation system during the perioperative period in patients undergoing endoscopic surgery of the paranasal sinuses

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