Activated coagulation times in normal cats and dogs using MAX‐ACT^TM tubes

Abstract

and Clinical Relevance In both cats and dogs, a MAX-ACT result >85 s should be considered abnormal and further coagulation testing should be performed. Additionally, failure to discard the first few drops of the sample does not appear to significantly affect results.

Red-bellied black snake (Pseudechis porphyriacus) envenomation in the dog: Diagnosis and treatment of nine cases

“…Whole blood activated clotting time (ACT) was performed by collecting 2 mL of whole blood and rapidly transferring to a commercial ACT tube (Actalyke, Helena Laboratories, Australia). The tube was gently mixed in the tube in a water bath at 37 C for 30 s and then inverted every 5e10 s to monitor for clot formation (See et al, 2009). A stopwatch was then used to manually time the interval until solid clot formation.…”

Effects of rest temperature, contact activation, and sample technique on canine thrombelastography

“…Because the effect of TF generated during venipuncture was thought to be minimal and also distributed among the total 8 mL drawn, it was hypothesized to have minimal effect, although this may not have been the case. While it has been established that the collection of a discard sample has minimal effect in coagulation tests that utilize a strong activator (eg, cellulite or TF), the effect on minimally activated coagulation tests such as TEG activated by recalcification alone has not been published.…”

Treatment of a massive naproxen overdose with therapeutic plasma exchange in a dog

“…Fluid replacement consisted of 1.2 L of lactated ringer's solution (Baxter Healthcare Corporation) and 400 mL of Hetastarch (Abbott Laboratories) premixed, administered throughout the TPE session. Anticoagulation was achieved with an initial bolus of 2400 units (100 U/kg) of unfractionated heparin (Heparin sodium injection 1000 USP Units/mL; Hospira Inc), followed by a continuous rate infusion of heparin at 1500 U/h to achieve an activated clotting time of 180‐250 seconds (reference range 60‐120 seconds) . The patient's systolic, diastolic, and mean arterial blood pressures, heart rate and rhythm, and respiratory rate and effort were monitored throughout the session; all values remained normal.…”

“…Anticoagulation was achieved with an initial bolus of 2400 units (100 U/kg) of unfractionated heparin (Heparin sodium injection 1000 USP Units/mL; Hospira Inc), followed by a continuous rate infusion of heparin at 1500 U/h to achieve an activated clotting time of 180-250 seconds (reference range 60-120 seconds). [17][18][19] The patient's systolic, diastolic, and mean arterial blood pressures, heart rate and rhythm, and respiratory rate and effort were monitored throughout the session; all values remained normal. Following TPE, 20 mL/kg of fresh frozen plasma was administered IV over 1 hour without complication as a way of replacing coagulation factors and other plasma components removed during the plasma exchange.…”