Activated Carbon-Enriched Electrospun-Produced Scaffolds for Drug Delivery/Release in Biological Systems

Nazarkina, Zhanna K.; Stepanova, Alena O.; Челобанов, Б. П.; Kvon, Ren I.; Simonov, P.A.; Карпенко, А. А.; Laktionov, Pavel P.

doi:10.3390/ijms24076713

Cited by 4 publications

(3 citation statements)

References 36 publications

(61 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The material was found to effectively deliver the drug to the site of damage, thereby facilitating bone healing. Nazarkin et al [37] conducted research on the release of drugs from electrospun nanofibers containing AC. Their work presented comprehensive studies of the materials obtained, which showed good biocompatibility and physicochemical properties.…”

Section: Introductionmentioning

confidence: 99%

Application of L-FDM Technology to the Printing of Tablets That Release Active Substances—Preliminary Research

Gabriel,

Olejnik,

Sztorch

et al. 2024

View full text Add to dashboard Cite

The following work presents a method for obtaining PLA composites with activated carbon modified using the liquid for fused deposition modeling (L-FDM) method in which two different compounds, i.e., rhodamine and antipyrine, are introduced. Tablets saturated with substances were obtained. Microscopic tests were carried out, and these confirmed the presence of substances that had been introduced into the polymer structure. UV-Vis spectra and observation of the active substance release process confirmed the relationship between the printing speed and the amounts of the compounds liberated from the tablets. Additionally, the contact angle of the PLA with activated carbon composites was characterized. The hydrophilic nature of the obtained composites favors an increase in the amounts of compounds released during the release process, which is a desirable effect. The surfaces and pores of the obtained materials were also analyzed. The incorporation of activated carbon into PLA results in a significant increase in its surface area. Investigations indicate that a novel approach for introducing chemicals into polymer matrices through the L-FDM method holds promise for the prospective fabrication of tablets capable of a controlled and customized release of substances tailored to individual requirements.

show abstract

Section: Introductionmentioning

confidence: 99%

Application of L-FDM Technology to the Printing of Tablets That Release Active Substances—Preliminary Research

Gabriel,

Olejnik,

Sztorch

et al. 2024

View full text Add to dashboard Cite

show abstract

“…PCL can be degraded either by hydrolytic or enzymatic pathways [7][8][9]. This polymer is used for different purposes in tissue engineering, including vascular grafting [10][11][12][13][14]. Although a lot of research has already been performed on this polymer, different research groups give diverse data concerning PCL in vivo performance as vascular grafts [15,16].…”

Section: Introductionmentioning

confidence: 99%

Remote Outcomes with Poly-ε-Caprolactone Aortic Grafts in Rats

Dokuchaeva,

Mochalova,

Timchenko

et al. 2023

Polymers

View full text Add to dashboard Cite

Poly-ε-caprolactone ((1,7)-polyoxepan-2-one; PCL) is a biodegradable polymer widely used in various fields of bioengineering, but its behavior in long-term studies appears to depend on many conditions, such as application specificity, chemical structure, in vivo test systems, and even environmental conditions in which the construction is exploited in. In this study, we offer an observation of the remote outcomes of PCL tubular grafts for abdominal aorta replacement in an in vivo experiment on a rat model. Adult Wistar rats were implanted with PCL vascular matrices and observed for 180 days. The results of ultrasound diagnostics and X-ray tomography (CBCT) show that the grafts maintained patency for the entire follow-up period without thrombosis, leakage, or interruptions, but different types of tissue reactions were found at this time point. By the day of examination, all the implants revealed a confluent endothelial monolayer covering layers of hyperplastic neointima formed on the luminal surface of the grafts. Foreign body reactions were found in several explants including those without signs of stenosis. Most of the scaffolds showed a pronounced infiltration with fibroblastic cells. All the samples revealed subintimal calcium phosphate deposits. A correlation between chondroid metaplasia in profound cells of neointima and the process of mineralization was supported by immunohistochemical (IHC) staining for S100 proteins and EDS mapping. Microscopy showed that the scaffolds with an intensive inflammatory response or formed fibrotic capsules retain their fibrillar structure even on day 180 after implantation, but matrices infiltrated with viable cells partially save the original fibrillary network. This research highlights the advantages of PCL vascular scaffolds, such as graft permeability, revitalization, and good surgical outcomes. The disadvantages are low biodegradation rates and exceptionally high risks of mineralization and intimal hyperplasia.

show abstract

“…An interesting aspect of nanomaterials used in biomedicine is their ability to modulate drug release kinetics. The article by Nazarkina et al [2] proposes an interesting strategy based on the incorporation of activated carbon into electrospun polycaprolactone fibers. These fibers can act as a retention barrier in the release of sirolimus from vascular stents, thus ensuring the long-term release of this drug and avoiding vascular restenosis.…”

mentioning

confidence: 99%