Activatable Photoacoustic Nanoprobes for In Vivo Ratiometric Imaging of Peroxynitrite

Zhang, Jianjian; Zhen, Xu; Upputuri, Paul Kumar; Pramanik, Manojit; Chen, Peng; Pu, Kanyi

doi:10.1002/adma.201604764

Cited by 243 publications

(182 citation statements)

References 39 publications

(27 reference statements)

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“…Subsequently, Pu and co‐workers designed the organic semiconducting nanoprobes, OSN‐B1 and OSN‐B2, for the PAD of ONOO − . The boronate‐caged boron‐dipyrromethene dye (BBD) of OSNs was served as the responsive component that could shift its NIR absorption for detection ( Figure a) . With the addition of ONOO − , an anionic phenoxide product with the characteristic maximum absorption at 745 nm was produced via the rapid oxidative cleavage of the borate ester moiety of BBD by ONOO − (Figure b).…”

Section: Applications Of Photoacoustic Detectionmentioning

confidence: 99%

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Photoacoustic Probes for Molecular Detection: Recent Advances and Perspectives

Zeng

Lin

et al. 2018

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Photoacoustic (PA) imaging (PAI) is a noninvasive and nonionizing biomedical imaging modality that combines the advantages of optical imaging and ultrasound imaging. Based on PAI, photoacoustic detection (PAD) is an emerging approach that is involved with the interaction between PA probes and analytes resulting in the changes of photoacoustic signals for molecular detection with rich contrast, high resolution, and deep tissue penetration. This Review focuses on the recent development of PA probes in PAD. The following contents will be discussed in detail: 1) the construction of PA probes; 2) the applications and mechanisms of PAD to different types of analytes, including microenvironments, small biomolecules, or metal ions; 3) the challenges and perspectives of PA probes in PAD.

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Section: Applications Of Photoacoustic Detectionmentioning

confidence: 99%

“…d) The ratiometric PA signals (PA 750 /PA 680 ) in the presence of various ROS in PBS. e) The real‐time PA spectra of tumor in living mice after intravenous administration of OSN‐B1 at 4 h. Reproduced with permission . Copyright 2017, Wiley‐VCH.…”

Section: Applications Of Photoacoustic Detectionmentioning

confidence: 99%

Photoacoustic Probes for Molecular Detection: Recent Advances and Perspectives

Zeng

Lin

et al. 2018

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“…The formulated Ir‐RGD‐TAT NCs (also designated as Ir‐R/T NCs) have been demonstrated to feature appealing tumor‐cell nucleus targeting performance and facilitate the sensitized tumor radiotherapeutics both in vitro and in vivo. Importantly, the synthesized Ir NCs are photonic‐hyperthermia active, contributing the underlying tumor hyperthermia and highly resolved photoacoustic (PA) imaging multimodalities . Synergized with the sensitized radiotherapy, the PEGylated dual‐targeting Ir NCs can offer total eradications of murine mammary 4T1 tumors, enabling the potential multimodal tumor therapeutics with high efficacy and therapeutic biosafety.…”

Section: Introductionmentioning

confidence: 99%

Construction of Nucleus‐Targeting Iridium Nanocrystals for Photonic Hyperthermia‐Synergized Cancer Radiotherapy

Wang

Zhang

Huo

et al. 2019

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Prominent tumor‐cell nucleus targeting of radiosensitizer substantially affects the therapeutic consequence of advanced tumor radiotherapy via lethal nucleus DNA damage. Herein, ultrasmall iridium nanocrystals (Ir NCs, <5 nm) are constructed for efficient tumor‐specific photonic hyperthermia‐synergized radiotherapy. To endow the NCs with qualified cell nucleus‐targeting performance, polyethylene glycol (PEG)‐modified Ir NCs are decorated with αvβ3 integrin‐targeting cyclic arginine‐glycine‐aspartic (c(RGDyC)), designated as RGD, peptides and human immunodeficiency virus‐1 transactivator of transcription protein(TAT), respectively, facilitating the tumor‐cell‐membrane (with overexpressed αvβ3 integrin) and cell‐nucleus targeting. The formulated Ir‐RGD‐TAT (Ir‐R/T) NCs are demonstrated to accumulate inside the nucleus of tumor cells and generate effective DNA lesions upon X‐ray irradiation. Further in vivo evaluations verify the satisfactory carcinoma destruction performance against 4T1 tumor xenografts. Importantly, the intriguing photonic NIR adsorption of Ir‐R/T NCs has enabled the hyperthermia therapeutics accompanied with photoacoustic imaging modalities, achieving clinically promising biocompatible multifunctional radiosensitized nanoplatforms for effective tumor therapeutics.

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“…[9] Recent developments of aza-BODIPY synthetic derivatives have allowed tailored design for specific moieties to promote their use as photoacoustic probes, [10] targeting conjugates, [11] optical sensors, [12] and off/ on switch systems. [14] Nanotechnology can significantly improve the bioavailability of aza-BODIPYs by resolving solubility issues in aqueous media, and this has led to the increasing popularity of supramolecular aza-BODIPY constructs as new biophotonic nanomaterials.A za-BODIPY molecules have been encapsulated in polymeric micelles, [15][16][17][18] quantum dots, [19] and inorganic nanoparticles. [14] Nanotechnology can significantly improve the bioavailability of aza-BODIPYs by resolving solubility issues in aqueous media, and this has led to the increasing popularity of supramolecular aza-BODIPY constructs as new biophotonic nanomaterials.A za-BODIPY molecules have been encapsulated in polymeric micelles, [15][16][17][18] quantum dots, [19] and inorganic nanoparticles.…”

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confidence: 99%

Stable J‐Aggregation of an aza‐BODIPY‐Lipid in a Liposome for Optical Cancer Imaging

et al. 2019

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Organic building blocks are the centerpieces of "one-for-all" nanoparticle development. Herein, we report the synthesis of anovel aza-BODIPY-lipid building blockand its self-assembly into al iposomal nanoparticle (BODIPYsome). We observed optically stable NIR J-aggregation within the BODIPYsome that is likely attributed to J-dimerization. BODIPYsomes with cholesterol showed enhanced colloidal stability while maintaining ah igh extinction coefficient (128 mm À1 cm À1 )a nd high fluorescence quenching (99.70 AE 0.09 %), whiche nables photoacoustic (PA) properties from its intact structure and recovered NIR fluorescence properties when it is disrupted in cancer cells.F inally,i ts capabilities for optical imaging (PA/fluorescence) were observed in an orthotopic prostate tumor mouse model 24 ha fter intravenous administration. Overall, the BODIPYsome opens the door for engineering new building blocks in the design of optically stable biophotonic imaging agents.

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Activatable Photoacoustic Nanoprobes for In Vivo Ratiometric Imaging of Peroxynitrite

Abstract: Organic semiconducting nanoprobes doped with bulky borane can undergo specific activation by ONOO even at tumor-relevant acidic pH (6.8), permitting in vivo ratiometric photoacoustic imaging of ONOO in the tumor environment of living mice.

Cited by 243 publications

References 39 publications

Photoacoustic Probes for Molecular Detection: Recent Advances and Perspectives

Photoacoustic Probes for Molecular Detection: Recent Advances and Perspectives

Construction of Nucleus‐Targeting Iridium Nanocrystals for Photonic Hyperthermia‐Synergized Cancer Radiotherapy

Stable J‐Aggregation of an aza‐BODIPY‐Lipid in a Liposome for Optical Cancer Imaging

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