Activatable albumin-photosensitizer nanoassemblies for triple-modal imaging and thermal-modulated photodynamic therapy of cancer

Hu, Dehong; Sheng, Zonghai; Gao, Guanhui; Siu, Fung‐Ming; Liu, Chengbo; Wan, Qian; Gong, Ping; Zheng, Hairong; Ma, Yifan; Cai, Lintao

doi:10.1016/j.biomaterials.2016.03.037

Cited by 140 publications

(93 citation statements)

References 46 publications

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“…These PS-containing NPs include inorganic NPs [11][12][13][14][15][16][17][18][19][20], quantum dots [21][22][23], liposomes [24][25][26], micelles [27][28][29][30], protein-based NPs [31][32][33][34][35][36], nucleic acid-based NPs [37,38], and porphysomes [39,40]. Besides, many stimuli-responsive polymeric drug carriers have been developed to achieve controlled release of PS molecules and activatable PDT strategy [41][42][43].…”

Section: Introductionmentioning

confidence: 99%

Plasma membrane activatable polymeric nanotheranostics with self-enhanced light-triggered photosensitizer cellular influx for photodynamic cancer therapy

Hao

Jiang

Zhu

et al. 2017

Journal of Controlled Release

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Section: Introductionmentioning

confidence: 99%

Plasma membrane activatable polymeric nanotheranostics with self-enhanced light-triggered photosensitizer cellular influx for photodynamic cancer therapy

Hao

Jiang

Zhu

et al. 2017

Journal of Controlled Release

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“…However, phototherapy has also some unresolved challenges . First of all, poor water solubility and poor specific delivery of photosensitizer often induce high toxicity to normal tissues . Second, low photothermal/photochemical conversion efficiency results in insufficient treatment effect .…”

Section: Introductionmentioning

confidence: 99%

Dye‐Anchored MnO Nanoparticles Targeting Tumor and Inducing Enhanced Phototherapy Effect via Mitochondria‐Mediated Pathway

Zhou

Meng

et al. 2018

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Phototherapy is a promising treatment method for cancer therapy. However, the various factors have greatly restricted phototherapy development, including the poor accumulation of photosensitizer in tumor, hypoxia in solid tumor tissue and systemic phototoxicity. Herein, a mitochondrial-targeted multifunctional dye-anchored manganese oxide nanoparticle (IR808@MnO NP) is developed for enhancing phototherapy of cancer. In this nanoplatform, IR808 as a small molecule dye acts as a tumor targeting ligand to make IR808@MnO NPs with capacity to actively target tumor cells and relocate finally in the mitochondria. Meanwhile, continuous production of oxygen (O ) and regulation of pH induced by the high reactivity and specificity of MnO NPs toward mitochondrial endogenous hydrogen peroxide (H O ) could effectively modulate tumor hypoxia and lessen the tumor subacid environment. Large amounts of reactive oxide species (ROS) are generated during the reaction process between H O and MnO NPs. Furthermore, under laser irradiation, IR808 in IR808@MnO NPs turns O into a highly toxic singlet oxygen ( O ) and generates hyperthermia. The results indicate that IR808@MnO NPs have the high efficiency of specific targeting of tumors, relieving tumor subacid environment, improving the tumor hypoxia environment, and generating large amounts of ROS to kill tumor cells. It is expected to have a wide application in treating cancer.

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“…However, typical PS agents absorb light in the ultraviolet/visible region and suffer from easy photodecomposition. 33,34 Therefore, it would be advantageous to build theranostic nanomedicines that enable simultaneous PTT and PDT following a single NIR laser exposure, which will achieve high therapeutic efficacy even at a moderate local temperature (<45 °C).…”

mentioning

confidence: 99%

Near-Infrared Emission CuInS/ZnS Quantum Dots: All-in-One Theranostic Nanomedicines with Intrinsic Fluorescence/Photoacoustic Imaging for Tumor Phototherapy

et al. 2016

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Many theranostic nanomedicines (NMs) have been fabricated by packaging imaging and therapeutic moieties together. However, concerns about their potential architecture instability and pharmacokinetic complexity remain major obstacles to their clinical translation. Herein, we demonstrated the use of CuInS/ZnS quantum dots (ZCIS QDs) as “all-in-one” theranostic nanomedicines that possess intrinsic imaging and therapeutic capabilities within a well-defined nanostructure. ZCIS QDs were exploited for multispectral optical tomography (MSOT) imaging and synergistic PTT/PDT therapy. Due to the intrinsic fluorescence/MSOT imaging ability of the ZCIS QDs, their size-dependent distribution profiles were successfully visualized at tumor sites in vivo. Our results showed that the smaller nanomedicines (ZCIS NMs-25) have longer tumor retention times, higher tumor uptake, and deeper tumor penetration than the larger nanomedicines (ZCIS NMs-80). The ability of ZCIS QDs to mediate photoinduced tumor ablation was also explored. Our results verified that under a single 660 nm laser irradiation, the ZCIS NMs had simultaneous inherent photothermal and photodynamic effects, resulting in high therapy efficacy against tumors. In summary, the ZCIS QDs as “all-in-one” versatile nanomedicines allow high therapeutic efficacy as well as noninvasively monitoring tumor site localization profiles by imaging techniques and thus hold great potential as precision theranostic nanomedicines.

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Activatable albumin-photosensitizer nanoassemblies for triple-modal imaging and thermal-modulated photodynamic therapy of cancer

Cited by 140 publications

References 46 publications

Plasma membrane activatable polymeric nanotheranostics with self-enhanced light-triggered photosensitizer cellular influx for photodynamic cancer therapy

Plasma membrane activatable polymeric nanotheranostics with self-enhanced light-triggered photosensitizer cellular influx for photodynamic cancer therapy

Dye‐Anchored MnO Nanoparticles Targeting Tumor and Inducing Enhanced Phototherapy Effect via Mitochondria‐Mediated Pathway

Near-Infrared Emission CuInS/ZnS Quantum Dots: All-in-One Theranostic Nanomedicines with Intrinsic Fluorescence/Photoacoustic Imaging for Tumor Phototherapy

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