Actions other than Smooth Muscle Relaxation may Play a Role in the Protective Effects of Formoterol on the Allergen-Induced Late Asthmatic Reaction

Brusasco, Vito; Crimi, Emanuele; Gherson, G; Nardelli, R.; Oldani, Virginio; Francucci, B; Cioppa, Giovanni Della; Senn, Stephen; Fabbri, Leonardo M.

doi:10.1006/pupt.2002.0366

Cited by 14 publications

(8 citation statements)

References 20 publications

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“…Previous studies have used larger single doses of LABA (salmeterol 100 ug, formoterol 24 ug) given before inhaled allergen and have demonstrated protection against allergen-induced increase in AHR. 12,13,23,26 This effect was not consistent at a lower dose. 27 Indeed, a dose-response effect has been demonstrated for the bronchodilator action of formoterol 28 and recently for its antiinflammatory activity.…”

Section: Discussionmentioning

confidence: 46%

The effects of inhaled budesonide and formoterol in combination and alone when given directly after allergen challenge

Duong

Gauvreau

Watson

et al. 2007

Journal of Allergy and Clinical Immunology

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Section: Discussionmentioning

confidence: 46%

The effects of inhaled budesonide and formoterol in combination and alone when given directly after allergen challenge

Duong

Gauvreau

Watson

et al. 2007

Journal of Allergy and Clinical Immunology

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“…Moreover, formoterol relaxes bronchial smooth muscle and also provides important clinical benefits in symptomatic patients with chronic obstructive pulmonary disease (21). Formoterol, as other long-acting ␤ 2 -adrenoceptor agonists, attenuates the allergen-induced late asthmatic reaction (22) and, under certain conditions, has more effect than other ␤ 2 -adrenoceptor agonists (salbutamol and salmeterol), as has been described previously (23).…”

Section: Introductionmentioning

confidence: 82%

Anticachectic Effects of Formoterol

et al. 2004

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In cancer cachexia both cardiac and skeletal muscle suffer an important protein mobilization as a result of increased proteolysis. Administration of the beta2-agonist formoterol to both rats and mice bearing highly cachectic tumors resulted in an important reversal of the muscle-wasting process. The anti-wasting effects of the drug were based on both an activation of the rate of protein synthesis and an inhibition of the rate of muscle proteolysis. Northern blot analysis revealed that formoterol treatment resulted in a decrease in the mRNA content of ubiquitin and proteasome subunits in gastrocnemius muscles; this, together with the decreased proteasome activity observed, suggest that the main anti-proteolytic action of the drug may be based on an inhibition of the ATP-ubiquitin-dependent proteolytic system. Interestingly, the beta2-agonist was also able to diminish the increased rate of muscle apoptosis (measured as DNA laddering as well as caspase-3 activity) present in tumor-bearing animals. The present results indicate that formoterol exerted a selective, powerful protective action on heart and skeletal muscle by antagonizing the enhanced protein degradation that characterizes cancer cachexia, and it could be revealed as a potential therapeutic tool in pathologic states wherein muscle protein hypercatabolism is a critical feature such as cancer cachexia or other wasting diseases.

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“…It has been proposed that actions other than ASM relaxation may play a role in the protective effect of long-acting β 2 -AR agonists against allergen-induced late asthmatic reactions [61]. In diseases such as asthma, ASM cells play a synthetic role by secreting inflammatory mediators [62].…”

Section: G-protein-coupled Receptor Signalingmentioning

confidence: 99%

Beta-Adrenergic Agonists

et al. 2010

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Inhaled β2-adrenoceptor (β2-AR) agonists are considered essential bronchodilator drugs in the treatment of bronchial asthma, both as symptoms-relievers and, in combination with inhaled corticosteroids, as disease-controllers. In this article, we first review the basic mechanisms by which the β2-adrenergic system contributes to the control of airway smooth muscle tone. Then, we go on describing the structural characteristics of β2-AR and the molecular basis of G-protein-coupled receptor signaling and mechanisms of its desensitization/ dysfunction. In particular, phosphorylation mediated by protein kinase A and β-adrenergic receptor kinase are examined in detail. Finally, we discuss the pivotal role of inhaled β2-AR agonists in the treatment of asthma and the concerns about their safety that have been recently raised.

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Actions other than Smooth Muscle Relaxation may Play a Role in the Protective Effects of Formoterol on the Allergen-Induced Late Asthmatic Reaction

Cited by 14 publications

References 20 publications

The effects of inhaled budesonide and formoterol in combination and alone when given directly after allergen challenge

The effects of inhaled budesonide and formoterol in combination and alone when given directly after allergen challenge

Anticachectic Effects of Formoterol

Beta-Adrenergic Agonists

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