Actions of Some Autonomic Drugs on Isolated Dog Quiescent Ureter

Ueda, Shoichi; Yano, Shoichiro; Sakanashi, Matao; Mutoh, Shinji; Ikegami, Keiichi

doi:10.1159/000473227

Cited by 3 publications

(4 citation statements)

References 10 publications

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“…In the present study, isolated dog ureters with out spontaneous activity were used as experi mental models, in which rhythmic contrac tions were evoked by an administration of potassium or phenylephrine to confirm parti cipation of calcium influx in the generation of such contractions. The former depolarizes cell membranes [13], and the latter stimu lates adrenergic ct-receptors in smooth mus cle [7,8]. The present observations of evoked ureteral contractions had a rhythm with regu larity and amplitude suggesting that ureteral smooth muscle possesses pace-making prop erties even if short strips of a length of 15 mm are used.…”

Section: Discussionmentioning

confidence: 47%

“…Only some ureteral preparations showed spontaneous contractions [7,8], The present study was carried out on preparations with out spontaneous activity, and the ureteral rhythmic contractions were induced by an addition of potassium (1.5 X 10'2A/) or phenylephrine (3 X 10_5M). Stable rhyth mic contractions continued for 1.5-2.0 h or more.…”

Section: Effects O F D Z On Evoked Ureteral Rhythmic Contractionsmentioning

confidence: 99%

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Comparative Effects of Diltiazem and Glycerol Trinitrate on Isolated Ureter and Coronary Artery of the Dog

Sakanashi¹,

Kato²,

Miyamoto³

et al. 1986

Pharmacology

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Effects of diltiazem on isolated ureter and coronary artery of the dog were compared with those of glycerol trinitrate (GTN). Diltiazem (DZ) (10^–9–10^–6M) decreased the force and frequency of ureteral rhythmic contractions evoked by potassium or phenylephrine in a concentration-dependent manner, and relaxed potassium-contracted coronary artery strips. The dose dependence of the inhibitory effects of diltiazem was similar on the ureter and coronary artery. GTN (10^–7–10^–5M) also showed similar inhibitory effects, but these were more pronounced on the coronary artery than on the ureter.

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Section: Discussionmentioning

confidence: 47%

Section: Effects O F D Z On Evoked Ureteral Rhythmic Contractionsmentioning

confidence: 99%

Comparative Effects of Diltiazem and Glycerol Trinitrate on Isolated Ureter and Coronary Artery of the Dog

Sakanashi¹,

Kato²,

Miyamoto³

et al. 1986

Pharmacology

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“…In our previous work [15], we showed that about 70% of isolated dog middle ureters had no spontaneous con tractions but the remaining 30% had, and that some autonomic drugs, especially alpha adrenoceptor stimu lants such as noradrenaline, adrenaline and phenyleph rine, could evoke the contractions in these ureters under quiescent state.…”

Section: Introductionmentioning

confidence: 89%

Actions of Some Autonomic Drugs on Spontaneous Contractions of Isolated Dog Ureter

et al. 1984

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Effects of some autonomic drugs on the isolated dog ureteral preparations showing spontaneous contractions were investigated quantitatively. Noradrenaline, adrenaline and phenylephnne produced increases in frequency and tension of the contractions which were reversed to decreases or depressed by phentolamine. Isoproterenol abolished the spontaneous contractions. Acetylcholine did not significantly change frequency and tension of the contractions. The results indicate that ureteral spontaneous contractions may be enhanced through an activation of Α-adrenoceptors and be attenuated through an activation of Β-adrenoceptors. However, acetylcholine will not display an important role on the ureteral contractions.

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“…Diminished vascular responses have been reported both in humans and rats with chronic renal failure (Campese et al 1981;Rascher 1982) and in rats with ARF produced by bilateral ureter ligation (Ueda et al 1981). In the study conducted by Rascher et a1 (1982) the vascular response to vasopressin in uraemic normotensive animals was unchanged whilst that to potassium chloride and barium chloride was increased.…”

Section: Discusionmentioning

confidence: 95%

Cardiovascular responses in spontaneously hypertensive rats with acute renal failure

Yates

Bowmer

Brown

1984

Journal of Pharmacy and Pharmacology

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Cardiovascular status and reactivity have been investigated in spontaneously hypertensive rats (SHR) with glycerol-induced acute renal failure. SHR with acute renal failure had significantly lower mean arterial blood pressures and heart rates. The pressor responses to noradrenaline and the chronotropic responses to right cervical sympathetic and vagal nerve stimulation were diminished in uraemic SHR compared to control SHR. The cardiovascular depression observed in SHR with acute renal failure was similar to that previously noted in normotensive rats with acute renal impairment.

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Actions of Some Autonomic Drugs on Isolated Dog Quiescent Ureter

Cited by 3 publications

References 10 publications

Comparative Effects of Diltiazem and Glycerol Trinitrate on Isolated Ureter and Coronary Artery of the Dog

Comparative Effects of Diltiazem and Glycerol Trinitrate on Isolated Ureter and Coronary Artery of the Dog

Actions of Some Autonomic Drugs on Spontaneous Contractions of Isolated Dog Ureter

Cardiovascular responses in spontaneously hypertensive rats with acute renal failure

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