Actions of “Loop” Diuretics and Mercurials Upon the Cochlea

Thalmann, Ruediger; Ise, Ikuo; Bohne, Barbara A.; Thalmann, Isolde

doi:10.3109/00016487709128836

Cited by 36 publications

(2 citation statements)

References 19 publications

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“…Such a role of this enzyme is established for the renal tubule, epithelia of the intestine, stomach and toad bladder [24] * but is only speculative for the inner ear. This speculation is primarily based on parallel effects of ethacrynic acid on strial adenylate cyclase and on the endolymphatic potential [25]. In this study we investigate the embryologic and early postnatal development of adenylate cyclase in the inner ear of the mouse and its possible correlation with the maturation of anatomical structures and inner ear fluids.…”

Section: Introductionmentioning

confidence: 99%

Adenylate cyclase activity in the fetal and the early postnatal inner ear of the mouse

Anniko¹,

Spångberg²,

Schacht³

1981

Hearing Research

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The adenylate cyclase activity was analyzed in fetal, early postnatal and adult inner ears of the CBA/CBA mouse and also in approximately one month old inner ears from Shaker -1 and Shaker -2 mice. A comparison was made with the maturation of potassium levels in endolymph as investigated with the X-ray energy dispersive technique. Adenylate cyclase activity in the developing normal inner ear shows two significant periods of increases: from the 16th to the 19th gestational day in both the cochlear and vestibular parts of the labyrinth, and from birth to day 6 after birth in the lateral wall tissues of the scala media. During the first period the anatomical boundaries of the secretory epithelia are developing. The postnatal rise in adenylate cyclase activity correlates with the morphological maturation of stria vascularis at the cellular and subcellular levels and the rise in potassium content of endolymph. The rise of enzyme activity in the cochlear during the maturation of endolymph supports a link between adenylate cyclase and the control of inner ear fluids. Adenylate cyclase activity in stria vascularis/spiral ligament of Shaker -1 and Shaker -2 mice were at normal levels and correlated better with the rather normal morphology of the tissues than the abnormal composition of endolymph in these mutants.

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Section: Introductionmentioning

confidence: 99%

Adenylate cyclase activity in the fetal and the early postnatal inner ear of the mouse

Anniko¹,

Spångberg²,

Schacht³

1981

Hearing Research

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“…The right cochlea from each animal was perfused with 2% osmium tetroxide in 0.2M phosphate buffer (pH 7.4) at 4°C and fixed in the same solution for two hours. The left cochleae were perfused with 2% glutaraldehyde in 0.2M sodium cacodylate buffer (pH7.4) at 4°C and fixed in the same solution for four hours. These left cochleae were postfixed for two hours at 0°C in 1%…”

mentioning

confidence: 99%

Mannitol-Induced Stria Vascularis Edema

Duvall¹,

Hukee²,

Santi³

1981

Archives of Otolaryngology - Head and Neck Surgery

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Noxious effects upon cochlear metabolism

Thalmann¹,

Thalmann²,

Ise³

et al. 1977

The Laryngoscope

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The influence of various toxic substances and of drugs with ototoxic side effects upon energy generation, energy utilization, and membrane processes of the cochlea were studied. None of the drugs tested interfered with energy generation to as great an extent as did anoxia or cyanide and 2,4‐dinitrophenol. Ouabain produced a pronounced interference with energy utilization of the stria vascularis. The “loop” diuretics ethacrynic acid and furosemide produced a reduction of energy utilization of a lesser degree than did ouabain. The “loop” diuretics do not seem to exert their toxic action upon strial Na+K+‐ATPase, but may act by interfering with strial adenylate cyclase. Aminoglycoside antibiotics and diuretic and nondiuretic mercurials seem to exert their primary noxious action upon cochlear function by interfering with membrane processes of the structures bounding the cochlear duct.

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Actions of “Loop” Diuretics and Mercurials Upon the Cochlea

Cited by 36 publications

References 19 publications

Adenylate cyclase activity in the fetal and the early postnatal inner ear of the mouse

Adenylate cyclase activity in the fetal and the early postnatal inner ear of the mouse

Mannitol-Induced Stria Vascularis Edema

Noxious effects upon cochlear metabolism

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