Action Potentials and Summating Potentials in the Normal Human Cochlea

Eggermont, Jos J.; Odenthal, D. W.

doi:10.1080/16512251.1974.11675746

Cited by 78 publications

(28 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The effects of high stimulus rate on the CAP have been extensively investigated in normal hearing adults and consist of CAP attenuation to approximately the same extent as that found in the present study (Eggermont and Odenthal, 1974b;Charlet de Sauvage and Aran, 1976;Wilson and Bowker, 2002;Ohashi et al, 2005). In contrast, few papers have addressed the issue of the effects of high stimulus rates on the SP amplitude.…”

Section: Adaptation Of Ecochg Potentials In Controlssupporting

confidence: 64%

“…In order to clarify whether these abnormally attenuated and prolonged potentials resulted from neural or receptor activations, we used an adaptation procedure that preferentially attenuates neural responses with minor changes in SP amplitude (Eggermont and Odenthal, 1974b).…”

Section: Discussionmentioning

confidence: 99%

“…This sequence was repeated every 191 ms. This stimulus paradigm was used to help distinguish between CAP and SP potentials by taking advantage of different effects of adaptation induced by high stimulation rates on these responses (Eggermont and Odenthal, 1974b). In the remaining AN subjects (#4, 8) and controls a repetitive click stimulation with an interstimulus interval of 91 ms was performed.…”

Section: Transtympanic Recordings: Electrocochleography (Ecochg)mentioning

confidence: 99%

“…Neural adaptation to fast stimulus rates reflects decreased responsiveness of both synaptic and spike generating processes (Eggermont and Odenthal, 1974b;Charlet de Sauvage and Aran, 1976). In the present study in control children, adaptation of the amplitude of the CAP was profound (68% reduction) whereas the decrease of the SP amplitude was significantly less averaging 27%.…”

Section: Adaptation Of Ecochg Potentials In Controlsmentioning

confidence: 99%

See 3 more Smart Citations

Neural and receptor cochlear potentials obtained by transtympanic electrocochleography in auditory neuropathy

Santarelli

Starr

Michalewski

et al. 2008

Clinical Neurophysiology

View full text Add to dashboard Cite

Objective: Transtympanic electrocochleography (ECochG) was recorded bilaterally in children and adults with auditory neuropathy (AN) to evaluate receptor and neural generators. Methods: Test stimuli were clicks from 60 to 120 dB p.e. SPL. Measures obtained from eight AN subjects were compared to 16 normally hearing children. Results: Receptor cochlear microphonics (CMs) in AN were of normal or enhanced amplitude. Neural compound action potentials (CAPs) and receptor summating potentials (SPs) were identified in five AN ears. ECochG potentials in those ears without CAPs were of negative polarity and of normal or prolonged duration. We used adaptation to rapid stimulus rates to distinguish whether the generators of the negative potentials were of neural or receptor origin. Adaptation in controls resulted in amplitude reduction of CAP twice that of SP without affecting the duration of ECochG potentials. In seven AN ears without CAP and with prolonged negative potential, adaptation was accompanied by reduction of both amplitude and duration of the negative potential to control values consistent with neural generation. In four ears without CAP and with normal duration potentials, adaptation was without effect consistent with receptor generation. In five AN ears with CAP, there was reduction in amplitude of CAP and SP as controls but with a significant decrease in response duration. Conclusions: Three patterns of cochlear potentials were identified in AN: (1) presence of receptor SP without CAP consistent with presynaptic disorder of inner hair cells; (2) presence of both SP and CAP consistent with post-synaptic disorder of proximal auditory nerve; (3) presence of prolonged neural potentials without a CAP consistent with post-synaptic disorder of nerve terminals. Significance: Cochlear potential measures may identify pre-and post-synaptic disorders of inner hair cells and auditory nerves in AN.

show abstract

Section: Adaptation Of Ecochg Potentials In Controlssupporting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Section: Transtympanic Recordings: Electrocochleography (Ecochg)mentioning

confidence: 99%

Section: Adaptation Of Ecochg Potentials In Controlsmentioning

confidence: 99%

See 2 more Smart Citations

Neural and receptor cochlear potentials obtained by transtympanic electrocochleography in auditory neuropathy

Santarelli

Starr

Michalewski

et al. 2008

Clinical Neurophysiology

View full text Add to dashboard Cite

show abstract

“…The same may be supposed for auditory evoked potentials (AEP) of more central origin because in the low-intensity limit the discharge probabilities at the various levels of the auditory pathway may be assumed to be linearly related. Published data, however, appear to be inconsistent with this conjecture as they suggest a linear relationship between response amplitude and sound level in decibels (see, e.g., Eggermont and Odenthal 1974;Elberling and Don 1987;Versnel et al 1992;. This means that the response amplitude seems to increase with the logarithm of sound intensity.…”

Section: Introductionmentioning

confidence: 99%

Auditory Brainstem Response at the Detection Limit

Lütkenhöner

Seither-Preisler

2008

JARO

View full text Add to dashboard Cite

Specific predictions regarding the level dependence of auditory evoked responses near the detection limit were made in a companion modeling study (Lütkenhöner, J Assoc Res Otolaryngol 9:102-121, 2008). Here, these predictions are experimentally tested for auditory brainstem responses (ABR) to Gaussian-shaped 4-kHz tone pulses (full width at half maximum=0.5 ms) that were presented at sound levels close to the subjective threshold. In the average of over about one million stimulus repetitions (repetition period=16 ms), the amplitude of ABR wave V showed a smooth transition from a proportional to a logarithmic growth with increasing sound intensity. The latter type of growth corresponds to a linear increase with respect to sound level measured in decibels. Alternatively, the ABR amplitude near the detection limit may be considered a linear function of sound pressure, although-according to the modelthis is only an approximation. Data and model are consistent with the view that a sensory threshold does not exist for the auditory modality, in accordance with signal detection theory. Even so, the model may be used to define a quasithreshold that is comparable to the subjective threshold.

show abstract

Brainstem Auditory-Evoked Responses

Stockard¹

1979

Arch Neurol

225

View full text Add to dashboard Cite

Action Potentials and Summating Potentials in the Normal Human Cochlea

Cited by 78 publications

References 9 publications

Neural and receptor cochlear potentials obtained by transtympanic electrocochleography in auditory neuropathy

Neural and receptor cochlear potentials obtained by transtympanic electrocochleography in auditory neuropathy

Auditory Brainstem Response at the Detection Limit

Brainstem Auditory-Evoked Responses

Contact Info

Product

Resources

About