Action potential propagation in mitral cell lateral dendrites is decremental and controls recurrent and lateral inhibition in the mammalian olfactory bulb

Margrie, Troy W.

doi:10.1073/pnas.011523098

Cited by 94 publications

(113 citation statements)

References 26 publications

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“…GCs mediate recurrent inhibition whereby GCs inhibit, in a reciprocal manner, the exact same MC that excited them. Additionally, GCs can mediate lateral inhibition between different MCs through inhibition of nearby MCs (Margrie et al, 2001; Shepherd et al, 2007). Other inhibitory networks involving periglomerular neurons have been suggested to contribute to the decorrelation of M/T ensembles, a process suggested to be central for odor discrimination (Aungst et al, 2003; Cleland, 2010).…”

Section: Introductionmentioning

confidence: 99%

Dissecting Local Circuits: Parvalbumin Interneurons Underlie Broad Feedback Control of Olfactory Bulb Output

Miyamichi

Shlomai-Fuchs

Shu

et al. 2013

Neuron

282

362

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Summary In the mouse olfactory bulb, information from sensory neurons is extensively processed by local interneurons before being transmitted to the olfactory cortex by mitral and tufted (M/T) cells. The precise function of these local networks remains elusive because of the vast heterogeneity of interneurons, their diverse physiological properties, and their complex synaptic connectivity. Here we identified the parvalbumin interneurons (PVNs) as a prominent component of the M/T presynaptic landscape by using an improved rabies-based trans-synaptic tracing method for local circuits. In vivo two-photon targeted patch recording revealed that PVNs have exceptionally broad olfactory receptive fields, and exhibit largely excitatory and persistent odor responses. Trans-synaptic tracing indicated that PVNs receive direct input from widely distributed M/T cells. Both the anatomical and functional extent of this M/T→PVN→M/T circuit contrasts with the narrowly confined M/T→granule cell→M/T circuit, suggesting that olfactory information is processed by multiple local circuits operating at distinct spatial scales.

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Section: Introductionmentioning

confidence: 99%

Dissecting Local Circuits: Parvalbumin Interneurons Underlie Broad Feedback Control of Olfactory Bulb Output

Miyamichi

Shlomai-Fuchs

Shu

et al. 2013

Neuron

282

362

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“…Individual mitral cells send their apical dendrites to a single glomerulus where they receive direct input from olfactory sensory neurons (OSNs) expressing a unique odorant receptor (Mombaerts et al, 1996), and different odors activate distinct ensembles of mitral cells (Bathellier et al, 2008; Kato et al, 2012; Rinberg et al, 2006; Tan et al, 2010; Wachowiak et al, 2013). Mitral cells receive a major source of inhibitory input from reciprocal dendrodendritic synapses with inhibitory neuron dendrites in the external plexiform layer (EPL) (Shepherd et al, 2004), which provide recurrent and lateral inhibition onto mitral cells (Isaacson and Strowbridge, 1998; Margrie et al, 2001; Schoppa et al, 1998). This circuit offers a basis for interglomerular inhibition that has been suggested to sharpen mitral cell odor tuning and enhance the contrast of odor representations (Yokoi et al, 1995), or alternatively, act more generally as a gain control mechanism regulating the dynamic range of mitral cell activity (Schoppa, 2009; Soucy et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Parvalbumin-Expressing Interneurons Linearly Control Olfactory Bulb Output

Kato

Gillet

Peters

et al. 2013

Neuron

164

196

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SUMMARY In the olfactory bulb, odor representations by principal mitral cells are modulated by local inhibitory circuits. While dendrodendritic synapses between mitral and granule cells are typically thought to be a major source of this modulation, the contributions of other inhibitory neurons remain unclear. Here we demonstrate the functional properties of olfactory bulb parvalbumin-expressing interneurons (PV cells) and identify their important role in odor coding. Using paired recordings, we find that PV cells form reciprocal connections with the majority of nearby mitral cells, in contrast to the sparse connectivity between mitral and granule cells. In vivo calcium imaging in awake mice reveals that PV cells are broadly tuned to odors. Furthermore, selective PV cell inactivation enhances mitral cell responses in a linear fashion while maintaining mitral cell odor preferences. Thus, dense connections between mitral and PV cells underlie an inhibitory circuit poised to modulate the gain of olfactory bulb output.

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“…Mitral and tufted cells receive sensory input from a single glomerulus and relay this information to the piriform cortex. Initial processing of sensory information occurs in the bulb, via input from local inhibitory interneurons onto mitral and tufted cells 25,26 . Thus, the spatially organized pattern of glomerular activation creates a sensory activation map specific to a given olfactory stimulus 27,28 .…”

mentioning

confidence: 99%

Developmental broadening of inhibitory sensory maps

et al. 2016

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Sensory maps are created by networks of neuronal responses that vary with their anatomical position, such that representations of the external world are systematically and topographically organized in the brain. Current understanding from studying excitatory maps is that maps are sculpted and refined throughout development and/or through sensory experience. Investigating the mouse olfactory bulb, where ongoing neurogenesis continually supplies new inhibitory granule cells into existing circuitry, we isolated the development of sensory maps formed by inhibitory networks. Using in vivo calcium imaging of odor responses, we compared functional responses of both maturing and established granule cells. We found that, in contrast to the refinement observed for excitatory maps, inhibitory sensory maps became broader with maturation. However, like excitatory maps, inhibitory sensory maps are sensitive to experience. These data describe the development of an inhibitory sensory map as a network, highlighting the differences from previously described excitatory maps.

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Action potential propagation in mitral cell lateral dendrites is decremental and controls recurrent and lateral inhibition in the mammalian olfactory bulb

Cited by 94 publications

References 26 publications

Dissecting Local Circuits: Parvalbumin Interneurons Underlie Broad Feedback Control of Olfactory Bulb Output

Dissecting Local Circuits: Parvalbumin Interneurons Underlie Broad Feedback Control of Olfactory Bulb Output

Parvalbumin-Expressing Interneurons Linearly Control Olfactory Bulb Output

Developmental broadening of inhibitory sensory maps

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