Abstract:Several peptide fragments of myelin basic protein (MBP) are formed in a brain during demyelinating diseases, which together with proinflammatory cytokines can influence proliferation and damage of glial cells. We studied the action of C8-isoform of MBP and its tryptic peptide fragments on viability (MTT-test) and on production of nitric oxide in rat primary glial cells. Two preparations of MBP hydrolizate were used: with-(Preparation 1) and without of encephalitogenic peptide 45-89 (Preparation 2), which was a… Show more
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