Action of various antidepressant treatments reduces reactivity of noradrenergic cyclic AMP-generating system in limbic forebrain

Vetulani, Jerzy; Sulser, Fridolin

doi:10.1038/257495a0

Cited by 588 publications

(161 citation statements)

References 10 publications

Supporting

Mentioning

152

Contrasting

Unclassified

Order By: Relevance

“…17 This finding is similar to binding studies, both in vivo and in vitro showing that chronic but not acute, treatment with antidepressants drugs and ECT downregulates ␤ 1 -adrenoceptors in rat forebrain. [29][30][31][32] Data from previous studies also suggest that adaptive changes in the 5-HT system may also play a pivotal role in the therapeutic effect of antidepressants. It has been shown that long-term TCA and repeated ECT lead to an enhanced 5-HT neurotransmission through a progressive sensitisation and upregulation of the postsynaptic 5-HT 1A receptors in the dorsal hippocampus.…”

Section: Effects On Receptorsmentioning

confidence: 90%

“…This pharmacological effect is one of the most consistent findings after chronic administration of antidepressants. 29 A recent study showed that chronic administration of hypericum downregulates ␤ 1 -adrenoceptors in the frontal cortex, with no change in receptor affinity. 17 This finding is similar to binding studies, both in vivo and in vitro showing that chronic but not acute, treatment with antidepressants drugs and ECT downregulates ␤ 1 -adrenoceptors in rat forebrain.…”

Section: Effects On Receptorsmentioning

confidence: 99%

See 1 more Smart Citation

The experimental and clinical pharmacology of St John's Wort (Hypericum perforatum L.)

Nathan

1999

Mol Psychiatry

View full text Add to dashboard Cite

Hypericum (St John's Wort) is a plant that has been used for centuries as a medicinal herb. Pre-clinical animals studies suggest that hypericum is effective in three major biochemical systems relevant for antidepressant activity, namely the inhibition of the synaptic re-uptake system for serotonin (5-HT), noradrenaline (NA) and dopamine (DA). It is the only antidepressant capable of inhibiting the re-uptake of 5-HT, NA and DA with similar potencies. The potencies for monoamine re-inhibition and chronic changes in receptors are also consistent with changes seen with known antidepressants. Behavioral studies suggest that hypericum is active in pre-clinical animal models of depression with comparable effects to known antidepressants. Supporting the pre-clinical pharmacology and efficacy, many clinical studies have shown that hypericum has superior efficacy compared to placebo and comparable efficacy to standard antidepressants in the treatment of mild-to-moderate depression. The advantage of hypericum over other antidepressants may result from its favorable side-effect profile. Although pre-clinical and short-term clinical studies demonstrate antidepressant activity, the lack of long-term use and efficacy, and the heterogeneity of patients, interventions, extract preparations from previous clinical studies suggests that more careful and controlled studies are needed to determine the long-term efficacy of hypericum in mild-to-moderate depression.

show abstract

Section: Effects On Receptorsmentioning

confidence: 90%

Section: Effects On Receptorsmentioning

confidence: 99%

The experimental and clinical pharmacology of St John's Wort (Hypericum perforatum L.)

Nathan

1999

Mol Psychiatry

View full text Add to dashboard Cite

show abstract

“…This discrepancy might be clarified by recent observations of the adaptive (reciprocal) changes demonstrated for NEactivated adenylate cyclase and adrenergic receptors in animals chronically treated with drugs known to alter functional catecholamine levels. Thus, chronic but not acute treatment with imipramine or DMI decreases the sensitivity of mesolimbic (20) and cortical (21) adenylate cyclase to stimulation by NE while decreasing f-receptor binding (22,23). In iontophoretic studies, chronic DMI treatment altered responsiveness to 5-hydroxytryptamine (24), and chronic Li treatment appeared to block the DA supersensitivity elicited by chronic haloperidol (25).…”

mentioning

confidence: 94%

Chronic treatment with lithium or desipramine alters discharge frequency and norepinephrine responsiveness of cerebellar Purkinje cells.

Siggins¹,

Schultz²

1979

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Cerebellar Purkinje cells were studied by electrophysiological techniques in rats treated chronically with either desipramine (DMI) or lithium chloride given intragastrically. A striking decrement occurred in discharge frequencies of simple spikes and climbing fiber bursts in both groups of animals, similar to the depression produced by iontophoresis of these agents. Chronic treatment with DMI markedly de- METHODSA total of 25 adult albino rats were used, with five groups in the DMI study. The first group ("chronic DMI, high") received, by gavage, DMI-HCl at 50 mg/kg in 2 ml of tap water once daily for 3 days, and then 30 mg/kg per day thereafter for 7-11 days. The second group ("chronic DMI, low") received DMI at 30 mg/kg per day for 8-18 days. These two "chronic groups" were tested electrophysiologically 24-36 hr after the last dose, when cerebellar DMI is roughly one-half the level during treatment (unpublished data). The third group ("controls") received 2 ml of tap water by gavage daily for 6-10 days. The fourth group ("DMI withdrawal") received DMI daily for 10 days and then treatment was terminated for 5 days before testing. In the fifth group ("acute DMI") animals received only one dose of DMI (30 mg/kg) by gavage prior to anesthesia and testing. The intragastric route of administration was chosen to maintain fairly constant brain levels of DMI and to avoid the peritonitis and resultant disruption of drug absorption often associated with chronic intraperitoneal injection.Four groups of animals were studied for Li effects. In the first group ("chronic Li"), LiCl at 60-75 mg/kg was administered once per day in 2 ml of water, by gavage for 9-12 days supplemented by ad lib intake of 10-15 mg/kg per day in the drinking water which also contained 0.9% NaCl. This group was tested electrophysiologically 2-12 hr after the last dose of LiCl, when serum Li levels were equal to those during treatment (unpublished data). A control group of rats received NaCl at 75 mg/kg per day by gavage as well as 0.9% NaCl in the drinking water. A third group ("Li withdrawal") received LiCI

show abstract

“…Several works have reported that the antidepressant drugs modulate the density of different heterotrimeric G proteins [103,105], as well as their functional response [127,143,44,179] (Table 1). Experimental evidences have shown that lithium attenuates the GPCR-induced modulation of the second messengers, even in the absence of changes in the density of the receptor [117].…”

Section: Effect Of Antidepressant Treatment In Animal Modelsmentioning

confidence: 99%

Heterotrimeric G Proteins: Insights into the Neurobiology of Mood Disorders

González-Maeso

Meana²

2006

View full text Add to dashboard Cite

Mood disorders such as major depression and bipolar disorder are common, severe, chronic and often lifethreatening illnesses. Suicide is estimated to be the cause of death in up to approximately 10-15% of individuals with mood disorders. Alterations in the signal transduction through G protein-coupled receptor (GPCR) pathways have been reported in the etiopathology of mood disorders and the suicidal behavior. In this regard, the implication of certain GPCR subtypes such as 2A -adrenoceptor has been repeatedly described using different approaches. However, several discrepancies have been recently reported in density and functional status of the heterotrimeric G proteins both in major depression and bipolar disorder. A compilation of the most relevant research topics about the implication of heterotrimeric G proteins in the etiology of mood disorders (i.e., animal models of mood disorders, studies in peripheral tissue of depressive patients, and studies in postmortem human brain of suicide victims with mood disorders) will provide a broad perspective of this potential therapeutic target field. Proposed causes of the discrepancies reported at the level of G proteins in postmortem human brain of suicide victims will be discussed.

show abstract

Action of various antidepressant treatments reduces reactivity of noradrenergic cyclic AMP-generating system in limbic forebrain

Cited by 588 publications

References 10 publications

The experimental and clinical pharmacology of St John's Wort (Hypericum perforatum L.)

The experimental and clinical pharmacology of St John's Wort (Hypericum perforatum L.)

Chronic treatment with lithium or desipramine alters discharge frequency and norepinephrine responsiveness of cerebellar Purkinje cells.

Heterotrimeric G Proteins: Insights into the Neurobiology of Mood Disorders

Contact Info

Product

Resources

About