Action of the Hypoglycemic Sulfonyl Compounds in Hypophysectomized, Adrenalectomized, and Depancreatized Animals

Houssay, B. A.; Penhos, J. C.; Teodósio, N. R.; Bowkett, J.; Apelbaum, J

doi:10.1111/j.1749-6632.1957.tb54570.x

Cited by 25 publications

(5 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Houssay 30 was the first to show that sulfonylureas could potentiate insulin action in vivo. Tolbutamide infusion into pancreatectomized dogs had no effect on the blood glucose concentration.…”

Section: Discussionmentioning

confidence: 99%

Mechanism of Improvement in Glucose Metabolism After Chronic Glyburide Therapy

et al. 1984

View full text Add to dashboard Cite

The effect of glyburide on glucose metabolism was examined in 10 non-insulin-dependent diabetic subjects (NIDDM) and 7 young, control subjects. After 3 mo of glyburide treatment in NIDDM, fasting plasma glucose declined from 198 to 141 mg/dl (P less than 0.01) without change in fasting insulin levels. Basal hepatic glucose production (HGP) was slightly elevated in NIDDM versus controls (2.35 versus 2.18 mg/kg X min, P = NS) and was positively correlated with the fasting glucose concentration (r = 0.93, P less than 0.001). With chronic glyburide therapy, HGP declined to 1.72 mg/kg X min (P less than 0.01 versus preglyburide) and remained highly correlated with the fasting glucose concentration (r = 0.85, P less than 0.005). Basal glucose clearance in NIDDM was reduced by 48% compared with age-matched controls (1.22 versus 2.32 ml/kg X min, P less than 0.001) and was unchanged after 3 mo of glyburide. Thus, the most important factor responsible for the decline in fasting plasma glucose concentration was an inhibition of hepatic glucose output. The decrease in basal hepatic glucose production and fasting plasma glucose concentration occurred without any change in fasting plasma insulin or C-peptide concentration. Insulin-mediated glucose metabolism (insulin clamp technique) was reduced by 55% in NIDDM (2.91 versus 6.39 mg/kg X min, P less than 0.001). After glyburide, insulin-mediated glucose metabolism increased by 26% to 3.67 mg/kg X min (P less than 0.01). This increase in tissue sensitivity to insulin was unassociated with any change in insulin binding to monocytes.(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract

Section: Discussionmentioning

confidence: 99%

Mechanism of Improvement in Glucose Metabolism After Chronic Glyburide Therapy

et al. 1984

View full text Add to dashboard Cite

show abstract

“…C'est plus tard encore que le mécanisme moléculaire sera précisé [16], l'inhibition des canaux potassiques ATP-dépendant de la celle béta-pancréatique. La place de Loubatières est progressivement reconnue [17]. Devenu titulaire de la chaire de Physiologie appliquée et Pharmacodynamie devenue Pharmacologie et Pharmacodynamie par la suite, membre de l'Académie des Sciences, il semble avoir manqué de peu la reconnaissance du prix Nobel de physiologie.…”

Section: Une Quête Physiologiqueunclassified

The discovery of hypoglycaemic sulphonamides – Montpellier, 1942

Lavabre‐Bertrand

Faillie

2021

Therapies

View full text Add to dashboard Cite

“…The principal action of the arylsulfonylureas is not mediated through the pituitary, thyroid or adrenal glands (14, 15, 42, 53, 55, 56). However, completely adrenalectomized rats and adrenal demedullated rats are more sensitive to the action of tolbutamide than are intact animals (57–59). This is probably due to the fact that epinephrine “blunts” the hypoglycemic effects of tolbutamide in the normal animal.…”

Section: Influence Of the Endocrine Glands Upon The Action Of Arylsulmentioning

confidence: 99%

A Critical Appraisal of Oral Hypoglycemic Agents†

McGavack¹

1959

J American Geriatrics Society

View full text Add to dashboard Cite

Action of the Hypoglycemic Sulfonyl Compounds in Hypophysectomized, Adrenalectomized, and Depancreatized Animals

Cited by 25 publications

References 1 publication

Mechanism of Improvement in Glucose Metabolism After Chronic Glyburide Therapy

Mechanism of Improvement in Glucose Metabolism After Chronic Glyburide Therapy

The discovery of hypoglycaemic sulphonamides – Montpellier, 1942

A Critical Appraisal of Oral Hypoglycemic Agents†

Contact Info

Product

Resources

About