Action of tannin on cellular membranes: Novel insights from concerted studies on lipid bilayers and native cells

Borisova, M. P.; Kataev, A. A.; Sivozhelezov, Victor

doi:10.1016/j.bbamem.2019.03.017

Cited by 18 publications

(18 citation statements)

References 33 publications

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“…Possibly, other types of polyphenols, which constituted a large part of these preparations may have weakened the inhibitory effects of hydrolysable tannins of preparations III and IV. It should be noted that 3,6-bis-O-digalloyl-1,2,4-tri-O-galloylβ-D-glucose, which is the major component of Preparation I, was recently shown to form anion-selective channels in lipid bilayers (Borisova et al, 2019). This effect may explain the secondary rising phase on the dose-response curve on the Figure 1a,c, suggesting that these newly formed pores functionally replace the VSOR channel by serving as a pathway for anion efflux.…”

Section: Discussionmentioning

confidence: 99%

Tannins, novel inhibitors of the volume regulation and the volume-sensitive anion channel

Tsiferova¹,

Khamidova

Amonov

et al. 2019

European Pharmaceutical Journal

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The volume-sensitive outwardly rectifying anion channel (VSOR) is a key component of volume regulation system critical for cell survival in non-isosmotic conditions. The aim of the present study was to test the effects of four tannin extracts with defined compositions on cell volume regulation and VSOR. Preparation I (98% of hydrolysable tannins isolated from leaves of sumac Rhus typhina L.) and Preparation II (100% of hydrolysable tannins isolated from leaves of broadleaf plantain Plantago major L) completely and irreversibly abolished swelling-activated VSOR currents in HCT116 cells. Both preparations profoundly suppressed the volume regulation in thymocytes with half-maximal effects of 40.9 μg/ml and 12.3 μg/ml, respectively. The inhibition was more efficient at lower concentrations but reverted at higher doses due to possible non-specific membrane-permeabilizing activity. Preparations III and IV (54,7% and 54.3% of hydrolysable tannins isolated, respectively, from roots and aboveground parts of Fergana spurge Euphorbia ferganensis B.Fedtch) inhibited VSOR activity in a partially reversible manner and suppressed the volume regulation with substantially higher half-maximal doses of 270 and 278 μg/ml, respectively, with no secondary reversion at higher doses. Hydrolysable tannins represent a novel class of VSOR channel inhibitors with the capacity to suppress the cell volume regulation machinery.

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Section: Discussionmentioning

confidence: 99%

Tannins, novel inhibitors of the volume regulation and the volume-sensitive anion channel

Tsiferova¹,

Khamidova

Amonov

et al. 2019

European Pharmaceutical Journal

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“…Electrostatically, tannins will be tethered to the outer protein-membrane and not the Ca2 + channels on the cell membrane. Cells that have been blocked by their Ca2 + channels will experience damage and die [19]. So that in R.lateristriata and D. rerio embryos with high exposure to D. alata, the embryos could not survive and even die before hatching because the toxins from HCN and tannins were quite strong.…”

Section: Effect Of D Alata On Embryo Development Of Danio Rerio and mentioning

confidence: 99%

The Effect of Dioscorea alata Extract on the Early Development of Zebrafish Embryo (Danio rerio) and Rasbora lateristriata

Raharjeng¹,

Retnoaji²

2021

Proceedings of the First International Conference on Science, Technology, Engineering and Industrial Revolution (ICSTEIR 2020)

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Dioscorea alata is reported to have many benefits and potentials, one of which is anti-diabetes since it contains Dioscorin and Glucomannan. D. alata used in this research is purple cultivar since it has higher antioxidant content than the other cultivar. This research will examine D. alata extract's effects on the early development of zebrafish (Danio rerio) and yellow rasbora (Rasbora lateristriata) embryos. The D. rerio and R. lateristriata embryos treatment was carried out on 3 hours post-fertilization (hpf) embryos aged. The embryos were exposed to D. alata, with 100mg/100ml, 500mg/100ml, and 1000mg/100ml. Biocompatibility assessment was carried out by measuring the hatching rate, survival rate, morphological changes, and heartbeat rate, respectively. The hatching rate was determined as the number of embryos that hatched at observation time. The survival rate was determined by the number of survive embryos at 12, 24, 36, 48, 60, 72 and 84 hpf, respectively. Moreover, the morphological change was observed on the shape of the embryo's heart and yolk and the tail-yolk detachment as an indicator of a normal body wall occurrence, respectively. Moreover, the physiological performance was decided base on the heartbeat rate performance of the embryos. Statistical analysis was performed by using the SPSS 21 application. One-way ANOVA was used to assess the significance of the effect of treatment on outcomes. The result showed a significant effect of D. alata on the hatching rate and survival rate, but it does not effect the embryo morphology and the heart rate in all treatments to Rasbora lateristriata and Danio rerio.

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“…Tannins interact with proteins through the aromatic rings of the polyphenols and hydrophobic moieties of amino acids—mainly pyrrolidine rings of proline residues, while hydrogen bonds are formed between the hydroxyl groups and the acceptor site for hydrogen in a protein ( Le Bourvellec and Renard, 2012 ). Hydrolysable tannins electrostatically bind to calcium dependent chloride channels located on the outer leaflet of the artificial cell membrane and inhibit them ( Borisova et al, 2019 ). It could be one of the possible mechanism of the antiplatelet activity of tannins since inhibition of chloride channels in platelet leads to membrane depolarization and hinders agonist-induced hyperpolarization and PS exposure ( Harper and Poole, 2013 ).…”

Section: Tannins and Plateletsmentioning

confidence: 99%

Tannins as Hemostasis Modulators

Marcińczyk

Gromotowicz-Popławska

Chabielska

2022

Front. Pharmacol.

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The hemostasis system is often affected by complications associated with cardiovascular diseases, which results in thromboembolic events. Compounds of plant origin and plant extracts are considered as a promising source of substances that could modulate the functioning of the hemostasis system and thus reduce the risk of thromboembolism. Among them, tannins, which are plant-origin compounds with potential effects in hemostasis, deserve a special mention. This paper describes the hemostasis-modifying ability of three groups of tannins, namely ellagitannins, gallotannins, and procyanidins. The review highlights the desirable as well as undesirable influence of tannins on specific components of hemostasis, namely platelets, coagulation system, fibrinolysis system, and endothelium, and the multidirectional effect of these compounds on the thrombotic process. Studies performed under normal and pathological conditions such as diabetes or hypercoagulation are described, and the pathophysiology-dependent action of tannins is also highlighted. Most of the studies presented in the paper were performed in vitro, and due to the low bioavailability of tannins more studies should be conducted in the future to understand their actual activity in vivo.

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Action of tannin on cellular membranes: Novel insights from concerted studies on lipid bilayers and native cells

Cited by 18 publications

References 33 publications

Tannins, novel inhibitors of the volume regulation and the volume-sensitive anion channel

Tannins, novel inhibitors of the volume regulation and the volume-sensitive anion channel

The Effect of Dioscorea alata Extract on the Early Development of Zebrafish Embryo (Danio rerio) and Rasbora lateristriata

Tannins as Hemostasis Modulators

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