Action of Synthetic Antimalarial Drugs on Psoriasis*

Cornbleet, Theodore

doi:10.1038/jid.1956.58

Cited by 68 publications

(12 citation statements)

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“…Whereas a minority of authors [4,12,17] report improve ment of p. after antimalarial drug treatment, others see no effect whatsoever [1,4,8]. The majority, however, observed exacerbation in a considerable proportion of patients, manifesting itself in the forma tion of new foci of the disease and the origin of crythrodermia [6,14,18,20], or a transition into pustular p. [15]. Our observations agree with the experiences of the last mentioned group of authors.…”

Section: Discussionmentioning

confidence: 99%

Photosensitive Psoriasis

Bielický¹,

Kvíčalová²

1964

Dermatology

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Section: Discussionmentioning

confidence: 99%

Photosensitive Psoriasis

Bielický¹,

Kvíčalová²

1964

Dermatology

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“…Antimalarial drugs are well known to be contraindicated in psoriasis (1). In particular, when utilized in psoriatic arthropathy.…”

Section: Sirmentioning

confidence: 99%

Hydroxychloroquine in Psoriasis: Is it Really Harmful?

Sorbara¹,

Cozzani²,

Rebora³

et al. 2006

Acta Derm Venereol

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“…The suggestion that antimalarials may be inadvisable in the management of psoriasis [16] is supported by in vitro studies of hydroxychloroquine and chloroquine.…”

Section: Discussionmentioning

confidence: 90%

“…Psoriasis treatment with or without concurrent HIV infection is not curative but only suppressive. Antimalarial drugs are generally considered to be contraindicated in psoriasis [16] but, there still is no strong evidence to refute or support the role of antimalarials in the exacerbation of psoriasis [17].…”

Section: Introductionmentioning

confidence: 99%

Successful Treatment of Psoriasis-like Lesions in HIV Infected Patients in Uganda with Chloroquine

Shihab¹,

Feld

Lutwama

et al. 2009

TOIDJ

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Abstract:The effect of chloroquine in the treatment of psoriasis remains controversial. Treatment of psoriasis in HIV infection is not well described. Chloroquine has been shown to have direct effects on both the Human Immunodeficiency Virus (HIV) and on the psoriasis disease process. The effect of chloroquine in HIV infected patients with psoriasis has not been well studied.We report on the effect of chloroquine on psoriasis-like lesions in three HIV infected patients who were not on antiretroviral therapy. Three consecutive HIV positive patients with CD4 cell count below 200cells/mm 3 had unequivocal improvement of their psoriasis-like lesions after 2 weeks of a daily dose of 150mg of chloroquine.In conclusion, chloroquine may be useful in the treatment of psoriasis-like lesions in patients with HIV infection particularly in resource poor settings. Ideally, a controlled clinical trial will be needed to confirm this.

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Action of Synthetic Antimalarial Drugs on Psoriasis*

Cited by 68 publications

References 0 publications

Photosensitive Psoriasis

Photosensitive Psoriasis

Hydroxychloroquine in Psoriasis: Is it Really Harmful?

Successful Treatment of Psoriasis-like Lesions in HIV Infected Patients in Uganda with Chloroquine

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