Action of rat uterine secretion on the corona cells of the ovum and its modification by sex hormones

Meglioli, G.; Desaulles, P. A.

doi:10.1007/bf01895579

Cited by 4 publications

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“…Therefore, in the isocarboxazid-treated group, with inhibited progesterone secretory activity 128,421, the reverse situation occurs, i.e., excessive number of sperm reach the oviduct. Progesterone also inhibits uterine sperm capacitation [23], and inhibits denudation of ova, which is necessary for sperm penetration [35]. Further research is needed to clarify the possible effects of adrenergic antagonists and M A 0 inhibitors on various parameters of conception.…”

Section: Discussionmentioning

confidence: 99%

Effect of Adrenoceptor Blockers and Maoi on Postcoital Utero-Oviductal Contractility, Sperm Transport, and Sperm Attachment to Eggs in Rabbits

Marsafy

Hafez

1981

Archives of Andrology

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Adult female rabbits were injected with phenoxybenzamine (a-adrenoceptor blocker) (Group I). propranolol (P-adrenoceptor blocker) (Group II), and Isocarboxazid (MAOI) (Group 111). Physiological saline was injected in the controls. Treatment started one day before mating and continued until autopsy. At 3, 12, and 24 hr postcoitum (PC), utero-oviductal contractions were recorded in vivo using microballoon-ended, fluid-filled catheters as pressure receptors. At 24 hr PC, all groups were autopsied and Bushings of the contralateral oviducts were evaluated for both sperm count and number of sperm attached andlor penetrating the eggs. Phenoxybenzamine induced reduction in the amplitude and frequency of both active contractions and resting pressure fluctuations. This suppressive effect was more remarkable at 12 and 24 hr PC than at 3 hr PC. Propranolol induced incoordination and instability in the uterooviductal resting pressure and increased the amplitude of isthmic contraction, and in frequency of uterine and ampullary contractions. Such excitatory effects were more pronounced at 3 hr PC than at 12 and 24 hr PC. More effective a-adrenergic blockade seemed to coincide with postovulatory progesterone dominance, increase in concentration, and response to genital tract PGE. More effective P-adrenoceptor blockade coincided with preovulatory estrogen dominance and increased concentration and response to genital tissue PGF. At 24 hr PC, sperm count was reduced in the oviduct and fewer numbers of sperm were attached to the eggs in phenoxybenzamine-and propranolol-treated females. Phenoxybenzamineinduced suppression of utero-oviductal contractions facilitated oviductal sperm ascent. Propranolol caused irregular sperm transport with rapid loss in the peritoneal cavity. At 24 hr PC, oviductal sperm count increased and an excessive number of sperm were attached to the eggs in isocarboxazid-treated rabbits. The pharmacology of sperm transport is discussed in relation to infertility and contraception.

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Section: Discussionmentioning

confidence: 99%

Effect of Adrenoceptor Blockers and Maoi on Postcoital Utero-Oviductal Contractility, Sperm Transport, and Sperm Attachment to Eggs in Rabbits

Marsafy

Hafez

1981

Archives of Andrology

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Cumulus cell dispersion induced by estradiol in mouse oviduct in vitro

1989

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Dispersion of cumulus cells in nonmated mice is completed in the oviduct 15-20 h after ovulation. Oviducts, isolated 1 h after ovulation (13 h post-human chorionic gonaditropin), were cultured in vitro for 40 h. In these oviducts, denuded oocytes were first seen at 30 h of culture, indicating that cumulus dispersion proceeded at a slower rate in vitro. Oocyte denudation was accelerated in a dose-dependent manner by the addition of estradiol to the culture medium in which oviducts were incubated. The addition of progesterone or cycloheximide to the culture medium strongly inhibited oocyte denudation even in the presence of estradiol. When isolated cumuli were incubated in the absence of oviductal tissue, the rate of cell dispersion was slower than that of cumuli incubated inside the oviduct and the addition of estradiol to the culture failed to accelerate this process. On the basis of these data, we propose that cumulus cell dispersion is accelerated by an estrogen-dependent protein produced by the oviduct and that this effect of estrogen is antagonized by progesterone.

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Uterine secretion during the sexual cycle in the rat and its capacity to disperse corona cells in vitro

Meglioli

Desaulles

1975

Experientia

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It was found that closure of the uterus disturbed the first 2 cycles after the operation; thereafter the normal cycle was resumed. The quantity of uterine fluid was increased at pro-oestrus and oestrus and reduced at met-oestrus and di-oestrus. Slight inverse changes in viscosity were observed. There was no significant difference in the pH. The corona-cell dispersing factor seems to be an oestrogen-dependent constituent of uterine secretion.

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Action of rat uterine secretion on the corona cells of the ovum and its modification by sex hormones

Cited by 4 publications

References 0 publications

Effect of Adrenoceptor Blockers and Maoi on Postcoital Utero-Oviductal Contractility, Sperm Transport, and Sperm Attachment to Eggs in Rabbits

Effect of Adrenoceptor Blockers and Maoi on Postcoital Utero-Oviductal Contractility, Sperm Transport, and Sperm Attachment to Eggs in Rabbits

Cumulus cell dispersion induced by estradiol in mouse oviduct in vitro

Uterine secretion during the sexual cycle in the rat and its capacity to disperse corona cells in vitro

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