Action of pentamidine-bound nanoparticles againstLeishmaniaon anin vivomodel

Abstract

Summary :The efficiency of antileishmanial agents may be enhanced by improving their bioavailability with a colloidal drug carrier. We

Altered transport properties of pentamidine-resistant Leishmania donovani and L. amazonensis promastigotes

“…Five female BALB/c mice were infected with 4 × 10 7 promastigotes each and another group of five mice, with 4 × 10 7 pentamidine-resistant promastigotes of L. donovani and L. amazonensis, respectively, by retro-orbital sinus injection (Fusai et al 1994). After 18 days, mice were killed.…”

Pentamidine-loaded poly(D,L-lactide) nanoparticles: Adsorption and drug release

“…It was found that pentamidine was bound to nanoparticles by ionic interaction. In vitro and in vivo experiments were also performed in order to evaluate the action of pentamidine-bound nanoparticles against intracellular Leishmania [Deniau et al, 1993;Fusaï et al, 1994]. Pentamidine loaded on polymethacrylate was sixfold more active than free drug in Leishmania infantum-infected mice .…”

Improvement of In Vitro and In Vivo Antileishmanial Activities of 2′,6′-Dihydroxy-4′-Methoxychalcone by Entrapment in Poly( d,l -Lactide) Nanoparticles

“…Despite the difficulty of access for soluble substances, the phagolysosomes easily accommodate particulate material by vesicle fusion (2,22). This feature is being used as a strategy to increase the bioavailability of drugs and reduce their toxicity (8,14). Amphotericin B has been successfully encapsulated in liposomes, with increased effectiveness and reduced toxicity for visceral (3,5,18,19) and cutaneous (17,23) leishmaniasis patients.…”