Action of Oren-gedoku-to on Platelet Aggregation <i>in Vitro</i>

Mori, Mikio; Hojo, Emiko; Takano, Kikuo

doi:10.1142/s0192415x9100020x

Cited by 4 publications

(3 citation statements)

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“…Sekiya & Okuda (1982) showed it to be an inhibitor of leukotrienes and prostaglandin biosynthesis (attributed to one of its components, Scutellariae Radix, which contains baicalin and baicalein). Fushitani et al (1995) showed it to act as a scavenger of free radicals whilst Mori et al (1991) reported it to be an inhibitor of platelet aggregation (due to Coptidis Rhizoma and Phellodendri Cortex which affect the cyclic nucleotide metabolic system mainly through the action of Berberine). Wang et al (1997) reported it to be an attenuator of IL-8.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Oren-gedoku-to on Experimental Colitis in Rats

Zhou

Mineshita

1999

Journal of Pharmacy and Pharmacology

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In Japan and China, Oren-gedoku-to (a complex mixture of ingredients derived from plants) has been used as a herbal medicine in the treatment of inflammatory and ulcerative diseases. In other countries salicylazosulfapyridine has been used to treat inflammatory bowel disease. In this study, we have compared the effect of Oren-gedoku-to with salicylazosulfapyridine on trinitrobenzene-sulphonic acid-induced colonic damage in rats, a model representative of ulcerative colitis and Crohn's disease in man. Oren-gedoku-to was administered orally for one or two weeks over a range of doses. Tissue damage scores, body weight, spleen weight, colon wet weight and colon wall thickness were measured, and colonic tissue levels of interleukin-8 (IL-8), leukotriene B4 (LTB4), prostaglandin E2 (PGE2), and myeloperoxidase activity were examined. The results indicated that Oren-gedoku-to was effective in the treatment of inflammatory bowel disease in the rat model. Histological observation showed a quicker healing process of the lesions, and a reduction of inflammatory cell infiltration following administration of Oren-gedoku-to. The precise mechanism of action for Oren-gedoku-to is still unclear; however, the reduction of IL-8, LTB4, and PGE2 observed suggests that the mechanism may be different from salicylazosulfapyridine (which has no effect on IL-8). There may be a potential benefit in offering combination therapy for the treatment of inflammatory bowel disease.

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Section: Discussionmentioning

confidence: 99%

The Effect of Oren-gedoku-to on Experimental Colitis in Rats

Zhou

Mineshita

1999

Journal of Pharmacy and Pharmacology

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“…Kim et al reported that HLJDD showed potent inhibitory effects on platelet aggregation and thrombus formation via inhibiting the phosphorylation of phospholipase C and protein kinase B in mice [ 131 ]. It has been validated that HLJDD can inhibit platelet aggregation and thrombosis in patients with cerebral infarction [ 132 ] and the rat model of MCAO [ 133 ].…”

Section: Effects Of Hljdd and Its Bioactive Components On The Neuropa...mentioning

confidence: 99%

Ancient Chinese Herbal Recipe Huanglian Jie Du Decoction for Ischemic Stroke: An Overview of Current Evidence

Yu¹,

Liu²,

Chen³

et al. 2022

Aging and disease

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Ischemic stroke is a major cause of mortality and neurological morbidity worldwide. The underlying pathophysiology of ischemic stroke is highly complicated and correlates with various pathological processes, including neuroinflammation, oxidative stress injury, altered cell apoptosis and autophagy, excitotoxicity, and acidosis. The current treatment for ischemic stroke is limited to thrombolytic therapy such as recombinant tissue plasminogen activator. However, tissue plasminogen activator is limited by a very narrow therapeutic time window (<4.5 hours), selective efficacy, and hemorrhagic complication. Hence, the development of novel therapies to prevent ischemic damage to the brain is urgent. Chinese herbal medicine has a long history in treating stroke and its sequela. In the past decades, extensive studies have focused on the neuroprotective effects of Huanglian Jie Du decoction (HLJDD), an ancient and classical Chinese herbal formula that can treat a wide spectrum of disorders including ischemic stroke. In this review, the current evidence of HLJDD and its bioactive components for ischemic stroke is comprehensively reviewed, and their potential application directions in ischemic stroke management are discussed.

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“…Huang-Lian-Jie-Du-Tang (HLJDT), a traditional Chinese medicinal prescription widely used in treating clinical stroke, is comprised of four common herbs, Rhizoma coptidis (Coptis chinensis Franch, Ranunculaceae), Radix scutellariae (Scutellaria baicalensis Georgi, Labiatae), Cortex phellodendri (Phellodendron amurense Rupr, Rutaceae) and Fructus gardeniae (Gardenia jasminoides Ellis, Rubiaceae), in a 3:2:2:3 proportion. In addition to having favorable effects on gastrointestinal disorders, acute liver injury and cardiovascular diseases, further evidence has indicated that HLJDT could have potential therapeutic effects on cerebral ischemia (Mori et al, 1991;Ohta et al, 1998;Takase et al, 1989;Wu et al, 2004). HLJDT has been used clinically to treat subjects suffering from stroke, sequelae of stroke or vascular dementia (Xu et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

The traditional Chinese medicine Huang-Lian-Jie-Du-Tang inhibits hypoxia- induced neuronal apoptosis

Zhang¹

2011

Afr. J. Pharm. Pharmacol.

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Huang-Lian-Jie-Du-Tang (HLJDT) has been used clinically for cerebral ischemia therapeutics. Here, we aimed to demonstrate whether and how HLJDT regulates neuronal apoptosis under hypoxia/ischemia. Apoptosis analysis was performed in vitro in PC12 cells with flow cytometry and in vivo in MCAO rats using TUNEL staining. The levels of caspase 9, caspase 3, Bcl-2, Bax and HIF-1α were demonstrated with western blotting. HLJDT remarkably inhibited apoptosis of neurons, both in vitro and in vivo. Caspase 9, caspase 3m Bcl-2, Bax and HIF-1α play important roles in anti-apoptotic effect of HLJDT on neuronal apoptosis hypoxia and ischemia induced.

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Action of Oren-gedoku-to on Platelet Aggregation in Vitro

Cited by 4 publications

References 0 publications

The Effect of Oren-gedoku-to on Experimental Colitis in Rats

The Effect of Oren-gedoku-to on Experimental Colitis in Rats

Ancient Chinese Herbal Recipe Huanglian Jie Du Decoction for Ischemic Stroke: An Overview of Current Evidence

The traditional Chinese medicine Huang-Lian-Jie-Du-Tang inhibits hypoxia- induced neuronal apoptosis

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