Action of Metabolic Poisons on the Isolated Retina: Relation of Histological to Biochemical Lesions

Lucas, Daniel; Newhouse, J. P.

doi:10.1136/bjo.43.3.147

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1960

2022

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Cited by 17 publications

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“…It is surprising, however, that respiratory activity was not more affected. In experiments with metabolic inhibitors (Lucas and Newhouse 1959) some depression of respiration was always found when there was histological evidence of necrosis. But glycolytic activity was sometimes depressed in the absence of necrosis and sometimes persisted in necrotic retinae.…”

Section: Introductionmentioning

confidence: 96%

The Effect of X-rays on the Metabolism of the Retina

Lucas

1966

International Journal of Radiation Biology and Related Studies

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The effect of x-rays on respiration and glycolysis was studied in organ cultures of the retina of the guinea-pig and the rat.(1) With the guinea-pig there was a rapid depression of respiration after doses of 2000 rad or more. The magnitude of the depression was proportional to the amount of histological damage in the visual cell layers. No effect on aerobic or anaerobic glycolysis was detected.(2) With the rat there was a moderate depression of both respiration and glycolysis after doses of 5000 rad or more. But the magnitude of the depression was not proportional to dose or to the amount of histological damage in the visual cell layers.(3) The differences in behaviour of the retinae of the two species is attributed to different metabolic and vascular patterns.

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Section: Introductionmentioning

confidence: 96%